Results 111 to 120 of about 2,928 (195)

ACKR3 is differentially expressed in glioblastoma.

Glioblastoma is difficult to treat and patients are often provided poor prognosis (1), indicating a requirement for therapeutic target identification and drug development. Differentially expressed genes represent by definition among the most promising targets for the development of novel chemotherapies (2, 3).
openaire   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Deciphering CXCR4 and ACKR3 interactomes reveals an influence of ACKR3 upon Gap junctional intercellular communication

Le déchiffrage de l'interactome de CXCR4 et ACKR3 révèle la régulation par ACKR3 de l'activité des jonctions Gap Le récepteur atypique ACKR3 et le récepteur CXCR4 sont des récepteurs couplés aux protéines G appartenant à la famille des récepteurs CXC des chimiokines.
openaire   +1 more source

Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent

bioRxiv
The atypical receptor ACKR3 works together with the canonical chemokine receptor CXCR4 to drive cell migration along gradients of their shared agonist CXCL12. CXCR4 promotes chemotaxis by activating canonical G protein pathways and recruiting β-arrestins.
Kai Wang, Tony Ngo, Ekta Khare, Rezvan Chitsazi, Suchismita Roy, Christopher T. Schafer, Tracy M. Handel, Irina Kufareva   +7 more
semanticscholar   +1 more source

Roxadustat Attenuates Adverse Remodeling Following Myocardial Infarction in Mice

Cells
Activation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α). To enhance the upregulation of HIF-1α, we administered roxadustat, a novel prolyl hydroxylase inhibitor (PHI ...
Marc-Michael Zaruba, Simon Staggl, Santhosh Kumar Ghadge, Thomas Maurer, Jasmina Gavranovic-Novakovic, Vivek Jeyakumar, Patric Schönherr, Andreas Wimmer, Gerhard Pölzl, Axel Bauer, Moritz Messner   +10 more
doaj   +1 more source

Endothelial Cells Communicate with Microglia and Retinal Ganglion Cells Through Igfbp3-Tmem219 and Cxcl12-Ackr3 Pathways in Diabetic Retinopathy

Open Ophthalmology Journal
The purpose of this research is to retrospectively analyze diabetic mouse retina datasets to obtain new insights into Diabetic Retinopathy (DR).
Ruojing Huang, Jian-Ying Chen, Yong Ding
semanticscholar   +1 more source

ACKR3 Gene [PDF]

, 2020
openaire   +1 more source

Bioinformatic Analysis and in Vitro Experimental Verification of the Intervention Effect of Shipi-Xiaoji Recipe on the Progression of non-Alcoholic Fatty Liver Disease to Liver Cancer

Natural Product Communications
Objective This study aimed to screen and identify central genes associated with the progression of non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC), to establish prognostic and clinical prediction models based on the expression
Jingting Zhang, Hongyao Chen, Kexiong Li, Wei Peng, Renyi Yang, Puhua Zeng   +5 more
doaj   +1 more source

The atypical chemokine receptor ACKR3/CXCR7 displays distinct binding and activation modes for its endogenous agonists

, 2017
Background The atypical chemokine receptor ACKR3, formerly CXCR7, binds the endogenous chemokines CXCL12 and CXCL11, as well as the virus-encoded chemokine vCCL2. ACKR3 is crucially involved in various physiological processes but also in viral infection
Szpakowska, Martyna, Ollert, Markus, Meyrath, Max Marc Roger, Julien, Hanson, Counson, Manuel, Chevigné, Andy, Reynders, Nathan   +6 more
core   +1 more source

ACKR3 wt Allele [PDF]

, 2020
openaire   +1 more source