Results 91 to 100 of about 2,928 (195)

Development and Validation of a Consensus Machine Learning–Derived Signature to Predict Survival and Treatment Benefits in Breast Cancer

Medicine Advances, Volume 4, Issue 1, Page 61-76, March 2026.
The consensus machine learning–derived prognostic signature (CMDPS) was developed by integrating 10 independent breast cancer cohorts and 76 algorithm combinations, which identified 19 robust survival‐associated genes. The CMDPS demonstrated superior prognostic performance compared to clinical features and 62 published transcriptome signatures ...
Guangyang Cheng, Zhan Wang, Fu Peng, Shuai Yang, Yudi Xu, Hongzhuo Qin, Run Shi, Zhaokai Zhou   +7 more
wiley   +1 more source

The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239

Clinical and Translational Science
Cytochrome P450 (CYP) 3A4 is an enzyme involved in the metabolism of many drugs that are currently on the market and is therefore a key player in drug–drug interactions (DDIs).
Christine Huynh, J. Dingemanse, H. E. Meyer zu Schwabedissen, Marlene Fonseca, P. Sidharta   +4 more
semanticscholar   +1 more source

Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 423-430, March 2026.
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang, Zhiqin Fang, Lam C. Tsoi, Johann E. Gudjonsson   +3 more
wiley   +1 more source

Hemin‐induced platelet activation is regulated by the ACKR3 chemokine surface receptor and has implications for passivation of vulnerable atherosclerotic plaques

The FEBS Journal
In vulnerable atherosclerotic plaques, intraplaque hemorrhages (IPH) result in hemolysis of red blood cells and release of hemoglobin and free hemin. Hemin activates platelets and leads to thrombosis.
Zoi Laspa, Valerie Dicenta-Baunach, David Schaale, Manuel Sigle, Ravi Hochuli, T. Castor, Alpaykut Bayrak, T. Harm, Karin Anne Lydia Müller, Thanigaimalai Pillaiyar, Stefan Laufer, A. Rohlfing, M. Gawaz   +12 more
semanticscholar   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

The discovery of small-molecule modulators for the ACKR3 receptor

, 2023
The atypical chemokine receptor 3 (ACKR3) is an attractive drug target for a new generation of chemotherapies. The inhibition of chemokine binding to ACKR3 by small-molecule agonists has shown reduced cancer activity in vivo and in vitro. However, despite the potential, a relatively low number of ligands has been disclosed in peer-reviewed scientific ...
openaire   +2 more sources

ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa

Glia
Barrier‐forming olfactory glia cells, termed sustentacular cells, play important roles for immune defense of the olfactory mucosa, for example as entry sites for SARS‐CoV‐2 and subsequent development of inflammation‐induced smell loss.
André Dietz, Katja Senf, Eva M Neuhaus
semanticscholar   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

A Preclinical Model of Inflammatory Breast Cancer to Study the Involvement of CXCR4 and ACKR3 in the Metastatic Process

Translational Oncology, 2015
Inflammatory breast cancer (IBC) is an aggressive and invasive tumor, accounting for 2.5% of all breast cancer cases, and characterized by rapid progression, regional and distant metastases, younger age of onset, and lower overall survival.
Roberto Wurth, Kevin Tarn, Danielle Jernigan, Sandra V. Fernandez, Massimo Cristofanilli, Alessandro Fatatis, Olimpia Meucci   +6 more
doaj   +1 more source