Results 71 to 80 of about 2,928 (195)
Structural basis of ligand interaction with atypical chemokine receptor 3
Nature Communications, 2017 The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ...
Martin Gustavsson +10 more
doaj +1 more source
GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity
Frontiers in Immunology, 2023 Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating ...
Serena Melgrati +16 more
doaj +1 more source
PLoS ONE, 2018 We observed in PRESTO-Tango β-arrestin recruitment assays that the α1-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological behavior.
Xianlong Gao +5 more
doaj +1 more source
Frontiers in Immunology, 2023 Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska +10 more
doaj +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.This study integrates single‐cell and bulk transcriptomes with machine learning to identify GNGT1 as an ESCC biomarker. Pan‐cancer, immune infiltration, pathway, and cell–cell communication analyses reveal TME associations. Exploratory treatment cohorts, in silico drug sensitivity, and molecular docking further support its therapeutic potential ...
Qian Yuan +5 more
wiley +1 more source
Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration
Frontiers in Immunology, 2019 Chemokine receptor CXCR4, its ligand stromal cell-derived factor-1 (CXCL12) and the decoy receptor atypical chemokine receptor 3 (ACKR3, also named CXCR7), are involved in the guidance of migrating cells in different anatomical districts.
Chiara Tobia +8 more
doaj +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
Molecular Medicine, 2022 Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA
Yu-bin He +12 more
doaj +1 more source
bioRxivThe canonical paradigm of GPCR signaling recognizes G proteins and β-arrestins as the two primary transducers that promote GPCR signaling. Recent evidence suggests the atypical chemokine receptor 3 (ACKR3) does not couple to G proteins, and β-arrestins ...
Chloe N. Hicks +8 more
semanticscholar +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• STK25 deficiency enhanced CAF‐mediated CRC growth via the NF‐κB/AREG/EGFR axis. • STK25 overexpression or AREG antibody overcame CAF‐mediated cetuximab resistance. • CRC patients with high STK25 and low CAFs marker levels might benefit from cetuximab treatment.
Yifan Hou +17 more
wiley +1 more source