Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]
, 2018 The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto +3 more
core +1 more source
Identification and analysis of mutational hotspots in oncogenes and tumour suppressors [PDF]
, 2017 Background: The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways ...
Baeissa, Hanadi +3 more
core +1 more source
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes [PDF]
, 2020 © 2020 The Authors G protein-coupled receptors are a major class of membrane receptors that mediate physiological and pathophysiological cellular signaling.
Caspar, Birgit +4 more
core +3 more sources
Plasticity of seven-transmembrane-helix receptor heteromers in human vascular smooth muscle cells.
PLoS ONE, 2021 Recently, we reported that the chemokine (C-X-C motif) receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) heteromerize with α1A/B/D-adrenoceptors (ARs) and arginine vasopressin receptor 1A (AVPR1A) in recombinant systems and in rodent and human
Lauren J Albee +2 more
doaj +1 more source
EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential
, 2020 Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P. +6 more
core +1 more source
Predicting Autism Spectrum Disorder Using Blood-based Gene Expression Signatures and Machine Learning [PDF]
, 2017 Objective: The aim of this study was to identify a transcriptomic signature that could be used to classify subjects with autism spectrum disorder (ASD) compared to controls on the basis of blood gene expression profiles.
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Senolytic Treatment With Fisetin Reverses Age‐Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12 [PDF]
Aging CellSingle‐cell transcriptomics identifies that oral, intermittent fisetin supplementation improves endothelial function by targeting senescent endothelial cell‐derived senescence‐associated secretory phenotype (SASP) factors and CXCL12 in old animals. The SASP and specifically CXCL12 were found to drive age‐related endothelial dysfunction by promoting ...
Mahoney S +14 more
europepmc +2 more sources
Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system [PDF]
, 2014 The proper functioning of the dopaminergic system requires the coordinated formation of projections extending from dopaminergic neurons in the substantia nigra (SN), ventral tegmental area (VTA) and retrorubral field to a wide array of forebrain targets ...
Abe, Philipp +7 more
core +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• STK25 deficiency enhanced CAF‐mediated CRC growth via the NF‐κB/AREG/EGFR axis. • STK25 overexpression or AREG antibody overcame CAF‐mediated cetuximab resistance. • CRC patients with high STK25 and low CAFs marker levels might benefit from cetuximab treatment.
Yifan Hou +17 more
wiley +1 more source