Results 51 to 60 of about 2,928 (195)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundRecently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1‐ARs through
Lauren J. Albee +7 more
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ACKR3–arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding
bioRxiv, 2023 Atypical chemokine receptor 3 (ACKR3, also known as CXCR7) is a scavenger receptor that regulates extracellular levels of the chemokine CXCL12 to maintain responsiveness of its partner, the G protein-coupled receptor (GPCR), CXCR4.
Qiuyan Chen +8 more
semanticscholar +1 more source
Nature Communications, 2020 The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and ACKR3 ...
Amos Fumagalli +15 more
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bioRxiv, 2023 The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration.
Christopher T. Schafer +4 more
semanticscholar +1 more source
CXCR4 and ACKR3 binding agents for imaging applications in cancer [PDF]
, 2019 The chemokine receptors CXCR4 and ACKR3 have been shown to be over-expressed in multiple types of cancer and are usually associated with aggressive phenotypes and poor prognosis. Successfully targeting and imaging the expression levels of these receptors
Renard, Isaline
core +6 more sources
Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function. [PDF]
PLoS ONE, 2017 Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function.
You-Hong Cheng +4 more
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Glia Cells Control Olfactory Neurogenesis by Fine-Tuning CXCL12
Cells, 2023 Olfaction depends on lifelong production of sensory neurons from CXCR4 expressing neurogenic stem cells. Signaling by CXCR4 depends on the concentration of CXCL12, CXCR4’s principal ligand.
André Dietz +4 more
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Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets
Cells, 2022 Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco +3 more
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Molecular Pharmacology, 2023 Atypical chemokine receptor 3 (ACKR3), formerly referred to as CXCR7, is considered to be an interesting drug target. In this study, we report on the synthesis, pharmacological characterization and radiolabeling of VUF15485, a new ACKR3 small-molecule ...
Aurelien M. Zarca +24 more
semanticscholar +1 more source
Research progress on the atypical chemokine receptor ACKR3 in cancer
Xin yixueAtypical chemokine receptor 3 (ACKR3), also known as CXC chemokine receptor 7 (CXCR7), has attracted increasing attention for its regulatory roles in the tumor microenvironment.
Pan SUN, Lei XU, Juan YANG
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