Modulation of non-canonical CXCR4 and ACKR3 functions [PDF]
The large family of G protein-coupled receptor (GPCR) family transduce extracellular signals via diverse signaling pathways to control physiological functions.
Perez Almeria, Claudia Victoria; id_orcid
core +2 more sources
TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers [PDF]
Communications BiologyChemokine receptors CXCR4 and ACKR3 are involved in multiple physiological and pathological processes. In overexpression systems, CXCR4 and ACKR3 form oligomers that are important for chemokine recognition and signaling.
Joyce Heuninck +17 more
doaj +2 more sources
The CXCL12γ/ACKR3 Axis Is a Critical Determinant of Myocardial Angiogenesis and Functional Recovery After Infarction [PDF]
JACC Basic Transl SciVisual ...
Duval V +16 more
europepmc +2 more sources
Compartmentalised signalling and trafficking of CXCR4 and ACKR3 [PDF]
The atypical chemokine receptor 3 (ACKR3) and the C-X-C chemokine receptor type 4 (CXCR4) are known to share the chemokine ligand CXCL12. CXCR4 and ACKR3 involvement in various types of cancer and their tumour environment has also been well-documented ...
Karsai, Noemi
core +6 more sources
Clinical and Translational ScienceCXCL12 acts as a chemoattractant by binding to the receptor CXCR4. The (atypical) chemokine receptor ACKR3 (CXCR7) scavenges CXCL12. Antagonism of ACKR3 thus leads to an increase in CXCL12 concentrations that has been used as a pharmacodynamic biomarker ...
Peter Blattmann +10 more
doaj +2 more sources
Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases [PDF]
Arthritis Research & TherapyBackground The C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are pivotal in tissue regeneration and inflammation, yet their role in osteoarthritis (OA) remains ambiguous.
Leonie Ruths +7 more
doaj +2 more sources
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides [PDF]
Nature Communications, 2020 Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath +13 more
doaj +2 more sources
ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis.
Journal of Investigative DermatologyCXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and function in steady-state skin; delve into their role in acute wound
Gabriela Cuesta-Margolles +2 more
semanticscholar +3 more sources
Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring
DevelopmentACKR3 scavenges and degrades the stem cell recruiting chemokine CXCL12, which is essential for proper embryonic and, in particular, haematopoietic development. Here, we demonstrate strong expression of ACKR3 on trophoblasts.
A. Fukuoka +6 more
semanticscholar +3 more sources
Regulation of the chemokine receptors CXCR4 and ACKR3 by receptor activity-modifying proteins [PDF]
Journal of Biological ChemistryThe chemokine CXCL12 and its two cognate receptors—CXCR4 and ACKR3—are key players in various homeostatic and pathophysiological processes, including embryonic development, autoimmune diseases, tissue repair, and cancer.
Fabian Pfersdorf +3 more
semanticscholar +4 more sources