Results 11 to 20 of about 27,026 (263)

Atypical chemokine receptors.

Exp Cell Res, 2011
Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs.
Ulvmar MH, Hub E, Rot A.
europepmc   +4 more sources

Atypical chemokine receptors: emerging therapeutic targets in cancer. [PDF]

Trends Pharmacol Sci, 2022
Atypical chemokine receptors (ACKRs) regulate the availability of chemokines via chemokine scavenging, while also having the capacity to elicit downstream function through β-arrestin coupling. This contrasts with conventional chemokine receptors that directly elicit immune cell migration through G protein-coupled signaling. The significance of ACKRs in
Torphy RJ, Yee EJ, Schulick RD, Zhu Y.
europepmc   +5 more sources

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

Shock, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +5 more sources

Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5)

Frontiers in Pharmacology, 2023
Atypical chemokine receptors (ACKRs) play pivotal roles in immune regulation by binding chemokines and regulating their spatial distribution without inducing G-protein activation.
Remy Bonnavion, Remy Bonnavion, Shangmin Liu, Haruya Kawase, Kenneth Anthony Roquid, Stefan Offermanns, Stefan Offermanns, Stefan Offermanns, Stefan Offermanns   +8 more
doaj   +4 more sources

Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets

Cells, 2022
Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco, Fernanda Agostini Rocha, Thiago Pinheiro Arrais Aloia, Luciana Cavalheiro Marti   +3 more
doaj   +3 more sources

Atypical chemokine receptor 4 shapes activated B cell fate [PDF]

Journal of Experimental Medicine, 2018
Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood.
Alsharifi, Mohammed, Babb, Rachelle, Bastow, Cameron R., Bourne, Katherine, Brink, Robert, Comerford, Iain, Cyster, Jason G., Fenix, Kevin A., Gilchrist, Derek S., Gregor, Carly E., Hermes, Jana R., Hill, Geoffrey R., Kara, Ervin E., McColl, Shaun R., McKenzie, Duncan R., Nibbs, Robert J., Norton, Todd S., Rodda, Lauren B., Tarlinton, David M., Vinuesa, Carola G., Zotos, Dimitra   +20 more
core   +9 more sources

Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy

Frontiers in Immunology, 2019
Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint ...
Valeria Mollica Poeta, Valeria Mollica Poeta, Matteo Massara, Arianna Capucetti, Arianna Capucetti, Raffaella Bonecchi, Raffaella Bonecchi   +6 more
doaj   +3 more sources

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies. [PDF]

Nat Commun
Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Di Niro L, Crudden C, Bebelman JP, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, Heukers R, Schafer CT, Smit MJ.   +19 more
europepmc   +5 more sources

Chemokine (C-X-C Motif) Receptor 4 and Atypical Chemokine Receptor 3 Regulate Vascular α1-Adrenergic Receptor Function [PDF]

Molecular medicine (Cambridge, Mass.), 2014
Chemokine (C-X-C motif) receptor (CXCR) 4 and atypical chemokine receptor (ACKR) 3 ligands have been reported to modulate cardiovascular function in various disease models. The underlying mechanisms, however, remain unknown. Thus, it was the aim of the present study to determine how pharmacological modulation of CXCR4 and ACKR3 regulate cardiovascular ...
Harold H. Bach, Yee M. Wong, Abhishek Tripathi, Amanda M. Nevins, Richard L. Gamelli, Brian F. Volkman, Kenneth L. Byron, Matthias Majetschak   +7 more
openalex   +3 more sources

Development of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies

Biochemistry and Biophysics Reports
Leukocyte migration is an essential function of innate and adaptive immune responses. Chemokines and their receptors control the migration system. The abundance of chemokines is controlled by atypical chemokine receptors (ACKRs), chemokine receptor-like ...
Miu Hirose, Hiroyuki Suzuki, Rena Ubukata, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato   +5 more
doaj   +3 more sources