Results 11 to 20 of about 174,841 (260)
Bidirectional Regulation of Opioid and Chemokine Function
Frontiers in Immunology, 2020 The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
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Chemokines and chemokine receptors in arthritis [PDF]
Frontiers in Bioscience, 2010 Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines.
Zoltan, Szekanecz +3 more
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Chemokine Receptors and Phagocyte Biology in Zebrafish
Frontiers in Immunology, 2020 Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs ...
Frida Sommer +2 more
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The Role of Atypical Chemokine Receptor CCXCKR (CCRL1) in Human Diseases [PDF]
International Journal of Basic Science in Medicine, 2016 The role of chemokines and their receptors have been identified in many biological activities such as immune response and angiogenesis; however, their regulatory ways are under investigation.
Parvin Salimi, Abolghasem Esmaeili
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STAR Protocols, 2023 Summary: Chemokine receptors, a subfamily of G-protein-coupled receptors (GPCRs), are responsible for cell migration during physiological processes as well as in diseases like inflammation and cancers.
Siyi Gu, Mian Huang, Tracy M. Handel
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Cells, 2022 Chemokine receptors are extensively involved in a broad range of physiological and pathological processes, making them attractive drug targets. However, despite considerable efforts, there are very few approved drugs targeting this class of seven ...
Stefanie Alexandra Eberle +1 more
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Chemokines and chemokine receptors: an overview
Frontiers in Bioscience, 2009 Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi +5 more
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Frontiers in Immunology, 2023 Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska +10 more
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Biomedical Papers, 2000 Chemokines mediate their multiple effects by binding to a variety of specific receptors, that comprise a subfamily of rhodopsin-like, 7-transmembrane domain receptors, coupled to G proteins. Some of these receptors serve as coreceptors for HIV, some of them could be expressed as markers for T lymphocyte functional differentiation.
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Teleost Chemokines and Their Receptors [PDF]
Biology, 2015 Chemokines are a superfamily of cytokines that appeared about 650 million years ago, at the emergence of vertebrates, and are responsible for regulating cell migration under both inflammatory and physiological conditions. The first teleost chemokine gene was reported in rainbow trout in 1998. Since then, numerous chemokine genes have been identified in
Steve Bird, Carolina Tafalla
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