Results 21 to 30 of about 4,115 (147)

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy [PDF]

Advanced Science
Conventional type 1 dendritic cells (cDC1s) play a crucial role in initiating and regulating antitumor immunity. However, the insufficient infiltration and dysfunctional state of these cells within the tumor microenvironment hinder antitumor immune ...
Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu, Jiao Lu, Yuanyuan Wei, Zixian Wu, Kai Li, Tiantian Zhang, Zonghong He, Pingping Zhu, Yuanming Qi, Benyu Liu, Hui Liu, Yongchao Wang, Zhenzhen Chen   +16 more
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Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control [PDF]

Frontiers in Immunology, 2019
Cross-presenting Xcr1+CD8α DCs are attractive APCs to target for therapeutic cancer vaccines, as they are able to take up and process antigen from dying tumor cells for their MHCI-restricted presentation to CD8 T cells.
Natalia K. Botelho, Benjamin O. Tschumi, Jeffrey A. Hubbell, Melody A. Swartz, Melody A. Swartz, Alena Donda, Pedro Romero   +6 more
doaj   +5 more sources

Macrophages in tertiary lymphoid structures promote apoptosis of ATF4-positive gastric cancer cells via IL18 [PDF]

Journal of Translational Medicine
Background Gastric cancer (GC) is a globally prevalent and highly fatal malignancy of the digestive system. Despite its transformative role in gastric cancer, immunotherapy’s efficacy is limited by the complexity and incomplete understanding of the ...
Lu Zhou, Xuelong Li, Junming Wu, Tianqing Zheng, Manru Lin, Yangjian Ou, Hong Zhou, Steven Mo, Xueqiong Han, Jinyu Xiang, Wenjing Gong   +10 more
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Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance [PDF]

Journal of Inflammation Research
Yiyu Hong,* Qiutong Chen,* Hua Xie, Mingliu Ma, Siting Gan, Yuqi Zhang, Zhaozhong Xu Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally ...
Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z   +6 more
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XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity [PDF]

Journal for ImmunoTherapy of Cancer
Background Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric antigen receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments of tumor tissues.
Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran   +10 more
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The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma [PDF]

Nature Communications
Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies.
Guozhong Jiang, Zhizhong Wang, Zhenguo Cheng, Weiwei Wang, Shuangshuang Lu, Zifang Zhang, Chinedu A. Anene, Faraz Khan, Yue Chen, Emma Bailey, Huisha Xu, Yunshu Dong, Peinan Chen, Zhongxian Zhang, Dongling Gao, Zhimin Wang, Jinxin Miao, Xia Xue, Pengju Wang, Lirong Zhang, Rathi Gangeswaran, Peng Liu, Louisa S. Chard Dunmall, Junkuo Li, Yongjun Guo, Jianzeng Dong, Nicholas R. Lemoine, Wencai Li, Jun Wang, Yaohe Wang   +29 more
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The role of XCR1 and its ligand XCL1 in antigen cross-presentation by murine and human dendritic cells [PDF]

Frontiers in Immunology, 2012
Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A. Kroczek, Volker eHenn
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Resurrected Ancestors Reveal Origins of Metamorphism in XCL1 [PDF]

Trends in Biochemical Sciences, 2021
In a recent study, Dishman et al. resurrected ancestors of the metamorphic chemokine, XCL1, inferred through phylogenetics, and found that metamorphism arose in the XCL1 lineage ~150 million years ago. A zigzagging evolutionary path suggests that the metamorphic properties are adaptive and reveals three design principles that could be used for ...
Patricia J. LiWang, Lee-Ping Wang, Andy LiWang   +2 more
openaire   +4 more sources

Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer [PDF]

Biochemistry, 2016
Known for its distinct metamorphic behavior, XCL1 interconverts between a canonical chemokine folded monomer (XCL1mon) that interacts with the receptor, XCR1, and a unique dimer (XCL1dim) that interacts with glycosaminoglycans and inhibits HIV-1 activity. This study presents the first detailed analysis of the GAG binding properties of XCL1dim.
Fox, Jamie C, Tyler, Robert C, Peterson, Francis C, Dyer, Douglas P, Zhang, Fuming, Linhardt, Robert J, Handel, Tracy M, Volkman, Brian F   +7 more
openaire   +5 more sources

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
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