Results 21 to 30 of about 4,678 (171)

The multifaceted role of XCL1 in health and disease [PDF]

Protein Science
AbstractThe chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability to stimulate the directional migration of cells. All chemokines adopt a very similar folded structure that binds a specific G protein‐coupled receptor (GPCR), and ...
Brian Volkman, Tara L Walker
exaly   +6 more sources

Structure-Function Relationship of XCL1

, 2021
Einleitung Chemokine vermitteln die Interaktion von Immunzellen. Das Chemokin XCL1 wird von aktivierten CD8+ T-Zellen und NK-Zellen sezerniert und besitzt die für Chemokine typische Tertiärstruktur, bestehend aus einem N-Terminus, einem antiparallelen β ...
Kroczek, Arthur Leonard
core   +2 more sources

A novel role for lymphotactin (XCL1) signaling in the nervous system: XCL1 acts via its receptor XCR1 to increase trigeminal neuronal excitability [PDF]

Neuroscience, 2018
Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor ...
Bird, E.V., Ilona Obara, King, A., Claire R. Christmas, Iannitti, T., Andreev, V., Tommaso Iannitti, Christmas, C., Veselin I. Andreev, Boissonade, F.M., Emma V. Bird, Anne E. King, Obara, I., Fiona M. Boissonade   +13 more
core   +5 more sources

Expression and Function of the C-Class Chemokine Lymphotactin (XCL1) in Wegener’s Granulomatosis [PDF]

The Journal of Rheumatology, 2009
Objective. In Wegener's granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying pathogenic mechanisms remain to be defined.
SABINE BLASCHKE, PHILIP BRANDT, Wessels, Johannes Theodor, Brandt, Philip, Mueller, Georg Anton, Blaschke, Sabine, GERHARD A. MÜLLER, JOHANNES T. WESSELS   +7 more
core   +4 more sources

Expression of Lymphotaktin (XCL1) in Wegener's Granulomatosis [PDF]

, 2012
ZIELSETZUNG: Bei den primär systemischen Vaskulitiden/Vaskulitis-Syndromen, wie beispielsweise der Wegener schen Granulomatose (WG), tritt in bis zu 20% der Fälle aufgrund einer rapid progredienten ...
Brandt, Philip
core   +3 more sources

The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]

PLoS ONE, 2017
The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li, Guoyan Wei, Yimei Cao, Dong Li, Pinghua Li, Jing Zhang, Huifang Bao, Yingli Chen, Yuanfang Fu, Pu Sun, Xingwen Bai, Xueqing Ma, Zengjun Lu, Zaixin Liu   +13 more
doaj   +2 more sources

dNK3 cells in normal pregnancy and recurrent pregnancy loss: from molecular identity to functional imbalance [PDF]

Frontiers in Immunology
BackgroundDecidual natural killer (dNK) cells constitute approximately 70% of first-trimester decidual leukocytes and play critical roles in immune tolerance, angiogenesis, and trophoblast invasion.
Lidan Liu, Zhao Zhang, Qianyi Huang, Bo Liu, Hongbo Wu   +4 more
doaj   +2 more sources

Genetic Regulation of DNA Methylation and Its Mediating Role in Blood Pressure: A Genome-Wide Twin Study. [PDF]

MedComm (2020)
Using 1056 Chinese twins, we estimated DNA methylation heritability (mean h2 = 18.3%) and genetic correlations with blood pressure. Association analyses identified 914 SBP‐related and 624 DBP‐related CpGs, with attenuation within monozygotic pairs. Integrating mQTL, GWAS, eQTL, and pQTL data identified bidirectional CpG–blood pressure relationships and
Hong X, Li M, Cao W, Lv J, Yu C, Huang T, Sun D, Liao C, Pang Y, Hu R, Gao R, Yu M, Zhou J, Wu X, Liu Y, Yin S, Gao W, Li L.   +17 more
europepmc   +2 more sources

Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis [PDF]

Frontiers in Immunology
BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory arthropathy with heritability estimated at approximately 90%, yet the effector genes and regulatory mechanisms beyond the well-established HLA-B*27 association remain incompletely defined ...
Fanyu Meng, Fanyu Meng, Ling Chen, Meng Li, Qingqing Zhang, Peiying Wang, Ruifeng Lin, Jiani Liu, Zhao Yuan, Kexin Chen, Zhaoxia Li, Yetong Xie, Abuduwahapu Aierken, Abuduwahapu Aierken, Furkat Yalkun, Furkat Yalkun, Chulan Li, Yuan Ma, Yuan Ma, Jianhui Chen, Ziwen Xu, Fei Zhong, Fei Zhong, Fei Zhong   +23 more
doaj   +2 more sources

Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer [PDF]

Cancer Immunology, Immunotherapy
Background Dendritic cells (DCs) derived extracellular vesicles represent a promising vehicle for the activation of adaptive immunity, demonstrating significant potential in the development of cancer nanovaccines.
Zhongqiang Fan, Zhao Wang, Hui Zhang, Hao Zhang, Rui Zhao, Shimiao Zhu, Xiaoqiang Liu   +6 more
doaj   +2 more sources