Results 21 to 30 of about 4,834 (170)

A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability [PDF]

Neuroscience, 2018
Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor (XCR1) in the nervous system.
Bird, E.V., Iannitti, T., Christmas, C., Obara, I., Andreev, V., King, A., Boissonade, F.M.   +6 more
openaire   +5 more sources

Expression and Function of the C-Class Chemokine Lymphotactin (XCL1) in Wegener’s Granulomatosis [PDF]

The Journal of Rheumatology, 2009
Objective.In Wegener’s granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying pathogenic mechanisms remain to be defined. We analyzed the expression and functional role of the C-class chemokine lymphotactin, XCL1, in WG.Methods.Sera and peripheral blood ...
Blaschke, Sabine, Brandt, Philip, Wessels, Johannes Theodor, Mueller, Georg Anton   +3 more
openaire   +4 more sources

The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]

PLoS ONE, 2017
The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li, Guoyan Wei, Yimei Cao, Dong Li, Pinghua Li, Jing Zhang, Huifang Bao, Yingli Chen, Yuanfang Fu, Pu Sun, Xingwen Bai, Xueqing Ma, Zengjun Lu, Zaixin Liu   +13 more
doaj   +2 more sources

Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer [PDF]

Biochemistry, 2016
Known for its distinct metamorphic behavior, XCL1 interconverts between a canonical chemokine folded monomer (XCL1mon) that interacts with the receptor, XCR1, and a unique dimer (XCL1dim) that interacts with glycosaminoglycans and inhibits HIV-1 activity. This study presents the first detailed analysis of the GAG binding properties of XCL1dim.
Fox, Jamie C, Tyler, Robert C, Peterson, Francis C, Dyer, Douglas P, Zhang, Fuming, Linhardt, Robert J, Handel, Tracy M, Volkman, Brian F   +7 more
openaire   +7 more sources

dNK3 cells in normal pregnancy and recurrent pregnancy loss: from molecular identity to functional imbalance [PDF]

Frontiers in Immunology
BackgroundDecidual natural killer (dNK) cells constitute approximately 70% of first-trimester decidual leukocytes and play critical roles in immune tolerance, angiogenesis, and trophoblast invasion.
Lidan Liu, Zhao Zhang, Qianyi Huang, Bo Liu, Hongbo Wu   +4 more
doaj   +2 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC [PDF]

Advanced Science
Tissue‐resident memory CD4+ T cells (CD4+ TRMs) are pivotal in immune responses during inflammation and infection, yet their phenotype and function within the tumor microenvironment (TME) remain elusive.
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
doaj   +2 more sources

A dual-function XCL1-CD40L mRNA adjuvant potentiates cancer vaccines by coordinating DC recruitment and maturation [PDF]

Frontiers in Immunology
BackgroundDespite the significant promise of mRNA tumor vaccines in treating solid tumors, their clinical response rate is constrained by the low effectiveness of antigen presentation resulting from the immune-suppressive tumor microenvironment (TME ...
Chunjie Wu, Wanxuan Shao, Yadi Liu, Shuyuan Pan, Shuyuan Pan, Wei Wang, Wei Wang, Li Deng, Li Deng, Suyue Zhang, Zhimin Cui, Yujiao Wang, Peng He, Peng He, Peng He, Yong Yang, Yiheng Zhao   +16 more
doaj   +2 more sources

Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis [PDF]

Frontiers in Immunology
BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory arthropathy with heritability estimated at approximately 90%, yet the effector genes and regulatory mechanisms beyond the well-established HLA-B*27 association remain incompletely defined ...
Fanyu Meng, Fanyu Meng, Ling Chen, Meng Li, Qingqing Zhang, Peiying Wang, Ruifeng Lin, Jiani Liu, Zhao Yuan, Kexin Chen, Zhaoxia Li, Yetong Xie, Abuduwahapu Aierken, Abuduwahapu Aierken, Furkat Yalkun, Furkat Yalkun, Chulan Li, Yuan Ma, Yuan Ma, Jianhui Chen, Ziwen Xu, Fei Zhong, Fei Zhong, Fei Zhong   +23 more
doaj   +2 more sources

A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases [PDF]

The Journal of Immunology, 2017
Abstract The integrin α9β1 is a key receptor involved in the development of autoimmune diseases. However, the detailed mechanism for the association of α9β1 integrin with its ligands remains unclear. In this study, we introduce XCL1/lymphotactin, a member of the chemokine family, as a novel ligand for α9 integrin.
Naoki Matsumoto, Shigeyuki Kon, Takuya Nakatsuru, Tomoe Miyashita, Kyosuke Inui, Kodai Saitoh, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Toshimitsu Uede, Tadashi Matsuda   +10 more
openaire   +3 more sources

Genetic Regulation of DNA Methylation and Its Mediating Role in Blood Pressure: A Genome-Wide Twin Study. [PDF]

MedComm (2020)
Using 1056 Chinese twins, we estimated DNA methylation heritability (mean h2 = 18.3%) and genetic correlations with blood pressure. Association analyses identified 914 SBP‐related and 624 DBP‐related CpGs, with attenuation within monozygotic pairs. Integrating mQTL, GWAS, eQTL, and pQTL data identified bidirectional CpG–blood pressure relationships and
Hong X, Li M, Cao W, Lv J, Yu C, Huang T, Sun D, Liao C, Pang Y, Hu R, Gao R, Yu M, Zhou J, Wu X, Liu Y, Yin S, Gao W, Li L.   +17 more
europepmc   +2 more sources