Results 61 to 70 of about 4,115 (147)

A ubiquitinated E2-based mRNA vaccine confers complete protection against lethal challenge with classical swine fever virus

Journal of Virology
Classical swine fever (CSF), caused by classical swine fever virus (CSFV), continues to threaten the global swine industry. Current E2-based subunit vaccines are limited by their slow adaptation to emerging viral strains and insufficient cell-mediated ...
Huanjie Zhai, Yuxuan Gao, Nian Wan, Yuxin Qu, Su Li, Lian-Feng Li, Ting Zhao, Qinghe Hou, Yuan Sun, Hongxia Wu, Yongfeng Li, Hua-Ji Qiu   +11 more
doaj   +1 more source

Hematopoietic Antigen Presenting Cells Fine‐Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Our study describes how the effector maturation of intrathymic iNKT and MAIT cells is guided by distinct hematopoietic APCs: DC1s for iNKT cells and macrophages for MAIT cells. ABSTRACT The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal‐associated invariant T (MAIT) cells, in the thymus is distinct ...
Yi Wang, Trang T. Lam, Sotaro Ochiai, Abbie R. Larson, Dean B. Matthews, Hamish E.G. McWilliam, Tsuneyasu Kaisho, Mireille H. Lahoud, Jose A. Villadangos, Gretchen E. Diehl, Franca Ronchese, Daniel G. Pellicci, Mark M.W. Chong   +12 more
wiley   +1 more source

XCL1 mediated by activation of mTOR pathway can promote the proliferation of drug-resistant breast cancer cell

Zhongguo aizheng zazhi, 2014
Background and purpose: More than 90% of cancer patients are incurable because of drug resistance. Activation of PI3K/Akt/mTOR signaling pathway in breast cancer, as a target for chemotherapy drugs has become a hot topic of breast cancer treatment.
白玉盘, 杨小利, 欧周罗
doaj  

Cellular Heterogeneity During Arterial Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu, Paul‐Lennard Mendez, Dimitri Kasakovski, Judith Sluimer   +3 more
wiley   +1 more source

XCL1 Enhances Regulatory Activities of CD4+CD25highCD127low/− T Cells in Human Allergic Asthma [PDF]

The Journal of Immunology, 2008
Abstract Chemokine-mediated recruitment of regulatory cell subsets to the airway during inflammation and enhancement of their activities are potential strategies for therapeutic development in allergic asthma (AA). In this study, we aim to explore the role of XCL1, a chemokine associated with immune suppression and allergy, on CD4 ...
Khoa D, Nguyen, Alison, Fohner, Jerome D, Booker, Chen, Dong, Alan M, Krensky, Kari C, Nadeau   +5 more
openaire   +2 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, Volume 13, Issue 35, 24 June 2026.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1 [PDF]

Science Signaling, 2019
Key amino acids in the chemokine XCL1 mediate its specificity for and activation of its receptor XCR1.
Fox, Jamie C., Thomas, Monica A., Dishman, Acacia F., Larsen, Olav, Nakayama, Takashi, Yoshie, Osamu, Rosenkilde, Mette Marie, Volkman, Brian F.   +7 more
openaire   +4 more sources

A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases [PDF]

The Journal of Immunology, 2017
Abstract The integrin α9β1 is a key receptor involved in the development of autoimmune diseases. However, the detailed mechanism for the association of α9β1 integrin with its ligands remains unclear. In this study, we introduce XCL1/lymphotactin, a member of the chemokine family, as a novel ligand for α9 integrin.
Naoki Matsumoto, Shigeyuki Kon, Takuya Nakatsuru, Tomoe Miyashita, Kyosuke Inui, Kodai Saitoh, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Toshimitsu Uede, Tadashi Matsuda   +10 more
openaire   +2 more sources

Patient‐derived organoid‐immune co‐cultures integrated with multi‐omics reveal immunotherapy resistance mechanisms in urothelial carcinoma

iMeta, Volume 5, Issue 3, June 2026.
Immunotherapy resistance presents a formidable challenge in tumor biology. While fibroblast growth factor receptor 3 (FGFR3) serves as a pivotal oncogenic driver in a multitude of cancers, the exploration of its role in immune checkpoint inhibitor (ICI) resistance remains scarce, thus impeding a deeper understanding of the tumor immune microenvironment
Shan Jiang, Yuxuan Song, Yun Peng, Ran Yan, Yunze Niu, Baoqiang Chen, Jiaxing Lin, Jilin Wu, Shixiang Wang, Yiqing Du, Caipeng Qin, Yihan Lin, Tao Xu   +12 more
wiley   +1 more source