Results 61 to 70 of about 4,834 (170)

Single‐cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

Clinical and Translational Medicine, 2021
Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes tumor progress and determines the outcome of therapeutic response.
Yan Mei, Weiwei Xiao, Hao Hu, Guanming Lu, Lingdan Chen, Zhun Sun, Mengdie Lü, Wenhui Ma, Ting Jiang, YuanHong Gao, LiRen Li, Gong Chen, Zifeng Wang, Hanjie Li, Duojiao Wu, Pinghong Zhou, Qibin Leng, Guangshuai Jia   +17 more
doaj   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Primers used for amplification cattle XCR1 and XCL1 genes.

, 2017
Primers used for amplification cattle XCR1 and XCL1 genes.
Xueqing Ma (3687436), Yingli Chen (383063), Zengjun Lu (313655), Huifang Bao (2221972), Xingwen Bai (313652), Zaixin Liu (313659), Yuanfang Fu (2221978), Dong Li (212687), Pinghua Li (173201), Pu Sun (313657), Guoyan Wei (3700651), Yimei Cao (313653), Jing Zhang (23775), Kun Li (277035)   +13 more
core   +1 more source

The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity. [PDF]

J Exp Med
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Ferry A, Mempel KM, Monell A, Reina-Campos M, Scharping NE, Heeg M, Takehara KK, Schokrpur S, Kuo N, Saddawi-Konefka R, Gutkind JS, Goldrath AW.   +11 more
europepmc   +4 more sources

Evolution of CAR‐T Therapy: Functional Engineering, Manufacturing Innovation, and Future In Vivo Strategies

Cancer Science, EarlyView.
CAR‐T therapy is evolving across four interconnected dimensions: functional engineering, manufacturing innovation, alternative cell sources, and in vivo CAR programming. Together, these advances address limitations in therapeutic efficacy, safety, manufacturing complexity, scalability, and accessibility, providing complementary paths toward the next ...
Yukimi Sakoda
wiley   +1 more source

Mitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca2+ Overload‐Mitophagy‐Ferroptosis Circuit

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Denervation‐induced muscle atrophy progresses during the interval between nerve injury and reinnervation, and depletion of muscle satellite cells (MuSCs) contributes to impaired functional recovery. Although mitochondrial dysfunction and impaired quality control are implicated in muscle wasting, whether excessive mitochondrial ...
Haiqi Ding, Jiagu Huang, Jiayao Zhang, Zhizhen He, Jun Luo, Zhao Lin, Linhai Yang, Yibin Su, Mingjuan Zhang, Fuli Wen, Yuan Lin, Cheng Chang, Hanhao Dai, Xuehui Ge, Jie Xu   +14 more
wiley   +1 more source

γδ T Cell–Secreted XCL1 Mediates Anti-CD3–Induced Oral Tolerance [PDF]

The Journal of Immunology, 2019
Abstract Oral tolerance is defined as the specific suppression of cellular and/or humoral immune responses to an Ag by prior administration of the Ag through the oral route. Although the investigation of oral tolerance has classically involved Ag feeding, we have found that oral administration of anti-CD3 mAb induced tolerance through
Rafael M Rezende, Brenda N Nakagaki, Thais G Moreira, Juliana R Lopes, Chantal Kuhn, Bruna K Tatematsu, Selma Boulenouar, Amir-Hadi Maghzi, Stephen Rubino, Gustavo B Menezes, Tanuja Chitnis, Howard L Weiner   +11 more
openaire   +2 more sources

A candidate nanoparticle vaccine comprised of multiple epitopes of the African swine fever virus elicits a robust immune response

Journal of Nanobiotechnology, 2023
The African swine fever (ASF) pandemics pose a significant threat to the global swine industry, and the development of safe and effective vaccines is a daunting but necessary challenge.
Jinxing Song, Mengxiang Wang, Lei Zhou, Panpan Tian, ZhuoYa Sun, Junru Sun, Xuannian Wang, Guoqing Zhuang, Dawei Jiang, Yanan Wu, Gaiping Zhang   +10 more
doaj   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, Volume 65, Issue 11, Page 1383-1397, November 2026.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Comprehensive identification of onco-exaptation events in bladder cancer cell lines revealed L1PA2-SYT1 as a prognosis-relevant event

iScience, 2023
Summary: Transposable elements (TEs) can provide ectopic promoters to drive the expression of oncogenes in cancer, a mechanism known as onco-exaptation.
Ziwei Wang, Yidie Ying, Maoyu Wang, Qing Chen, Yi Wang, Xufeng Yu, Wei He, Jing Li, Shuxiong Zeng, Chuanliang Xu   +9 more
doaj   +1 more source