Results 71 to 80 of about 4,678 (171)
Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek +3 more
wiley +1 more source
Zhongguo aizheng zazhi, 2014 Background and purpose: More than 90% of cancer patients are incurable because of drug resistance. Activation of PI3K/Akt/mTOR signaling pathway in breast cancer, as a target for chemotherapy drugs has become a hot topic of breast cancer treatment.
白玉盘, 杨小利, 欧周罗
doaj
Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome
iMetaOmics, Volume 3, Issue 3, September 2026.A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng +20 more
wiley +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, Volume 59, Issue 9, September 2026.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Primary human CD8+ T cells secrete XCL1.
, 2013 CD8+ T cells were activated with three different stimuli for 3 days: PMA plus ionomycin, anti-CD3/CD28 loaded beads, or PHA. Cells were washed and culture supernatants were harvested after 5 and 7 days to quantify XCL1 secretion.
Christina Guzzo (305744) +7 more
core +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan +24 more
wiley +1 more source
, 2003 To better characterize the cellular source of lymphotactin (XCL1), we compared XCL1 expression in different lymphocyte subsets by real-time PCR. XCL1 was constitutively expressed in both PBMC and CD4+ cells, but its expression was almost 2 log higher in ...
SEBELIN A +6 more
core +1 more source
A Bacterial Microbiome Is Dispensable for the Induction of CD8 T Cell Exhaustion
European Journal of Immunology, Volume 56, Issue 8, August 2026.We infected Germ‐free and normal SPF mice infected with strains of LCMV that cause chronic infections. In both types of mice, T cell exhaustion progressed to similar levels. Thus, the microbiome is dispensable for the induction of T cell exhaustion.
Miriam Kuhlmann +11 more
wiley +1 more source
Endothelial Atypical Receptors for Chemoattractants in Lung Immune Surveillance
European Journal of Immunology, Volume 56, Issue 8, August 2026.Control of chemokine gradients within tissues is achieved by atypical chemokine receptors (ACKRs). The lungs require tightly regulated leukocyte recruitment for effective host defense while preventing tissue damage. In this context, ACKRs expressed by lung endothelial cells are emerging as critical regulators of leukocyte trafficking and inflammatory ...
Mattia Laffranchi +8 more
wiley +1 more source
XCL1 does not interact with or inhibit VSV-G-pseudotyped virus.
, 2013 (A) Virion capture was performed using anti-mouse immunomagnetic beads (M-Beads) armed with anti-VSV-G mAb (Anti-VSV) or anti-rabbit immunomagnetic beads (R-Beads) armed with XCL1 WT (XCL1). Equal amounts of VSV-G-pseudotyped virus were added to all bead
Christina Guzzo (305744) +7 more
core +1 more source