Results 91 to 100 of about 4,678 (171)

The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma

Nature Communications
Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies.
Guozhong Jiang, Zhizhong Wang, Zhenguo Cheng, Weiwei Wang, Shuangshuang Lu, Zifang Zhang, Chinedu A. Anene, Faraz Khan, Yue Chen, Emma Bailey, Huisha Xu, Yunshu Dong, Peinan Chen, Zhongxian Zhang, Dongling Gao, Zhimin Wang, Jinxin Miao, Xia Xue, Pengju Wang, Lirong Zhang, Rathi Gangeswaran, Peng Liu, Louisa S. Chard Dunmall, Junkuo Li, Yongjun Guo, Jianzeng Dong, Nicholas R. Lemoine, Wencai Li, Jun Wang, Yaohe Wang   +29 more
doaj   +1 more source

Image_1_Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control.TIFF

, 2019
Cross-presenting Xcr1+CD8α DCs are attractive APCs to target for therapeutic cancer vaccines, as they are able to take up and process antigen from dying tumor cells for their MHCI-restricted presentation to CD8 T cells.
Melody A. Swartz (112385), Natalia K. Botelho (6398738), Pedro Romero (7146), Jeffrey A. Hubbell (118232), Benjamin O. Tschumi (6398741), Alena Donda (5514965)   +5 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity

Signal Transduction and Targeted Therapy
Severe cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease
Lele Sun, Pengcheng Huai, Zhenzhen Wang, Qing Zhao, Yingjie Lin, Tingting Liu, Xiaotong Xue, Suiting Ao, Jiabao You, Yonghu Sun, Zihao Mi, Joshua Gardner, Paul J. Thomson, Dean J. Naisbitt, Xiaoli Meng, Jianjun Liu, Hong Liu, Furen Zhang   +17 more
doaj   +1 more source

Systemic trafficking of macrophages in implant wear debris-induced periprosthetic osteolysis

SLAS Technology
Periprosthetic osteolysis (PPOL) is a significant complication post-joint replacement, often instigated by implant wear debris, leading to chronic inflammation and bone resorption.
Mengyun Lou
doaj   +1 more source

The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation

, 2019
Physical exercise has well-established anti-inflammatory effects, with neuro-immunological crosstalk being proposed as a mechanism underlying the beneficial effects of exercise on brain health. Here, we used physical exercise, a strong positive modulator
Walker, Tara L., Seidemann, Suse, Bernas, Stefanie N., Overall, Rupert W., Kempermann, Gerd, Kowal, Susann, Leiter, Odette, Horenburg, Cindy   +7 more
core   +1 more source

Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis [PDF]

, 2009
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8? T-cells and directs migration of CD4? and CD8? lymphocytes and natural killer (NK) cells.
Franco Molina, Moisés Armides, Villatoro Hernández, Julio, Zavala Flores, Laura Mireya, Villanueva Olivo, Arnulfo, Gámez Escobedo, Idalia Analí, Rangel Colmenero, Blanca Rocío, Gutiérrez Puente, Yolanda, Valdés Flores, Jesús, Saucedo Cárdenas, Odila, Montes de Oca Luna, Roberto   +9 more
core   +1 more source

Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy

Journal for ImmunoTherapy of Cancer
Background The interleukin (IL)-1-family receptor antagonist IL-38 has emerged as a negative regulator of auto-inflammation. Given the intricate interplay between antitumor immunity and auto-inflammation, we hypothesized that blocking IL-38 may enhance ...
Andreas Ernst, Andreas Weigert, Priscila da Silva, Javier Mora, Xin You, Svenja Wiechmann, Mateusz Putyrski, Javier Garcia-Pardo, Aimo Kannt, Bernhard Bruene   +9 more
doaj   +1 more source

XCL1 antiviral activity is equally effective before and after digestion of glycosaminoglycans on PBMC.

, 2013
PBMC were incubated in the presence (‘Heparitinase-treated’) or absence (‘Untreated’) of heparitinase to digest cell surface glycosaminoglycan expression, followed by infection with HIV-1 IIIB (A) or BaL (B) in the presence of XCL1 WT (green bars), W55D (
Christina Guzzo (305744), Jamie Fox (502456), Raffaello Cimbro (172335), Paolo Lusso (172366), Huiyi Miao (172330), Anthony S. Fauci (73431), Yin Lin (421396), Brian F. Volkman (502457)   +7 more
core   +1 more source

Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome

Biomolecules
Objective: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder with an increased risk for cardiovascular disease (CVD) that is enhanced by obesity.
Manjula Nandakumar, Priya Das, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin   +4 more
doaj   +1 more source