Results 91 to 100 of about 6,545 (188)

Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1 [PDF]

Science Signaling, 2019
Key amino acids in the chemokine XCL1 mediate its specificity for and activation of its receptor XCR1.
Fox, Jamie C., Thomas, Monica A., Dishman, Acacia F., Larsen, Olav, Nakayama, Takashi, Yoshie, Osamu, Rosenkilde, Mette Marie, Volkman, Brian F.   +7 more
openaire   +4 more sources

The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor

Virology Journal, 2008
Background Large DNA-viruses such as herpesvirus and poxvirus encode proteins that target and exploit the chemokine system of their host. The Kaposi sarcoma- associated herpes virus (KSHV) encodes three chemokines.
Lüttichau Hans R
doaj   +1 more source

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology

Barrier Immunity, Volume 2, Issue 1, Page 6-22, March 2026.
Tissue‐resident memory T (TRM) cells in barrier tissues provide a frontline defense against invading pathogens. Immune (Signals 1–3) and nutrient (Signal 4) cues play an integral role in directing TRM formation and heterogeneity. The spatial and temporal organization of these signals establishes durable TRM cells across tissues, enabling diverse ...
Jana L. Raynor, Hongbo Chi
wiley   +1 more source

A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases [PDF]

The Journal of Immunology, 2017
Abstract The integrin α9β1 is a key receptor involved in the development of autoimmune diseases. However, the detailed mechanism for the association of α9β1 integrin with its ligands remains unclear. In this study, we introduce XCL1/lymphotactin, a member of the chemokine family, as a novel ligand for α9 integrin.
Naoki Matsumoto, Shigeyuki Kon, Takuya Nakatsuru, Tomoe Miyashita, Kyosuke Inui, Kodai Saitoh, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Toshimitsu Uede, Tadashi Matsuda   +10 more
openaire   +2 more sources

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation [PDF]

, 2016
Background: Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood.
V. Proserpio, A. Piccolo, L. Haim-Vilmovsky, G. Kar, T. Lnnberg, V. Svensson, J. Pramanik, K. Natarajan, W. Zhai, X. Zhang, G. Donati, M. Kayikci, J. Kotar, A.N. Mckenzie, R. Montandon, O. Billker, S. Woodhouse, P. Cicuta, M. Nicodemi∗, S.A. Teichmann∗
core   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1 [PDF]

Journal of Virology, 2015
ABSTRACT HIV-1 replication is regulated in vivo by a complex network of cytokines and chemokines. XCL1/lymphotactin, a unique metamorphic chemokine, was recently identified as a broad-spectrum endogenous HIV-1 inhibitor that blocks viral entry via direct interaction with the gp120 envelope glycoprotein ...
Christina, Guzzo, Jamie C, Fox, Huiyi, Miao, Brian F, Volkman, Paolo, Lusso   +4 more
openaire   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration [PDF]

, 2017
Varicella zoster virus (VZV) is a highly prevalent human pathogen that establishes latency in neurons of the peripheral nervous system. Primary infection causes varicella whereas reactivation results in zoster, which is often followed by chronic pain ...
Binz, Anne, Duran, Veronica, Gonzalez-Motos, Victor, Jürgens, Carina, Kaufer, Benedikt B., Kropp, Kai A., Larsen, Olav, Ritter, Birgit   +7 more
core   +1 more source