Results 91 to 100 of about 4,834 (170)

XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity

Journal for ImmunoTherapy of Cancer
Background Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric antigen receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments of tumor tissues.
Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran   +10 more
doaj   +1 more source

XCL1 inhibits HIV-1 infection irrespective of coreceptor usage.

, 2013
(A) Dose-dependent inhibition of prototypic X4 (magenta) and R5 (blue) HIV-1 strains (IIIB and BaL) by recombinant XCL1 (Peprotech) in PBMC. Virus replication was assessed by measuring the amount of p24 Gag antigen in culture supernatants via AlphaLISA ...
Christina Guzzo (305744), Jamie Fox (502456), Raffaello Cimbro (172335), Paolo Lusso (172366), Huiyi Miao (172330), Anthony S. Fauci (73431), Yin Lin (421396), Brian F. Volkman (502457)   +7 more
core   +1 more source

XCL1 antiviral activity is equally effective before and after digestion of glycosaminoglycans on PBMC.

, 2013
PBMC were incubated in the presence (‘Heparitinase-treated’) or absence (‘Untreated’) of heparitinase to digest cell surface glycosaminoglycan expression, followed by infection with HIV-1 IIIB (A) or BaL (B) in the presence of XCL1 WT (green bars), W55D (
Christina Guzzo (305744), Jamie Fox (502456), Raffaello Cimbro (172335), Paolo Lusso (172366), Huiyi Miao (172330), Anthony S. Fauci (73431), Yin Lin (421396), Brian F. Volkman (502457)   +7 more
core   +1 more source

The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation

, 2019
Physical exercise has well-established anti-inflammatory effects, with neuro-immunological crosstalk being proposed as a mechanism underlying the beneficial effects of exercise on brain health. Here, we used physical exercise, a strong positive modulator
Walker, Tara L., Seidemann, Suse, Bernas, Stefanie N., Overall, Rupert W., Kempermann, Gerd, Kowal, Susann, Leiter, Odette, Horenburg, Cindy   +7 more
core   +1 more source

The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma

Nature Communications
Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies.
Guozhong Jiang, Zhizhong Wang, Zhenguo Cheng, Weiwei Wang, Shuangshuang Lu, Zifang Zhang, Chinedu A. Anene, Faraz Khan, Yue Chen, Emma Bailey, Huisha Xu, Yunshu Dong, Peinan Chen, Zhongxian Zhang, Dongling Gao, Zhimin Wang, Jinxin Miao, Xia Xue, Pengju Wang, Lirong Zhang, Rathi Gangeswaran, Peng Liu, Louisa S. Chard Dunmall, Junkuo Li, Yongjun Guo, Jianzeng Dong, Nicholas R. Lemoine, Wencai Li, Jun Wang, Yaohe Wang   +29 more
doaj   +1 more source

CD8(+)alphabeta(+) T cells that lack surface CD5 antigen expression are a major lymphotactin (XCL1) source in peripheral blood lymphocytes

, 2003
To better characterize the cellular source of lymphotactin (XCL1), we compared XCL1 expression in different lymphocyte subsets by real-time PCR. XCL1 was constitutively expressed in both PBMC and CD4+ cells, but its expression was almost 2 log higher in ...
SEBELIN A, CHIECO BIANCHI, LUIGI, TOSELLO, VALERIA, ROSATO, ANTONIO, STIEVANO L, MARCATO N, AMADORI, ALBERTO   +6 more
core   +1 more source

TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity

Signal Transduction and Targeted Therapy
Severe cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease
Lele Sun, Pengcheng Huai, Zhenzhen Wang, Qing Zhao, Yingjie Lin, Tingting Liu, Xiaotong Xue, Suiting Ao, Jiabao You, Yonghu Sun, Zihao Mi, Joshua Gardner, Paul J. Thomson, Dean J. Naisbitt, Xiaoli Meng, Jianjun Liu, Hong Liu, Furen Zhang   +17 more
doaj   +1 more source

Systemic trafficking of macrophages in implant wear debris-induced periprosthetic osteolysis

SLAS Technology
Periprosthetic osteolysis (PPOL) is a significant complication post-joint replacement, often instigated by implant wear debris, leading to chronic inflammation and bone resorption.
Mengyun Lou
doaj   +1 more source

Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis [PDF]

, 2009
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8? T-cells and directs migration of CD4? and CD8? lymphocytes and natural killer (NK) cells.
Franco Molina, Moisés Armides, Villatoro Hernández, Julio, Zavala Flores, Laura Mireya, Villanueva Olivo, Arnulfo, Gámez Escobedo, Idalia Analí, Rangel Colmenero, Blanca Rocío, Gutiérrez Puente, Yolanda, Valdés Flores, Jesús, Saucedo Cárdenas, Odila, Montes de Oca Luna, Roberto   +9 more
core   +1 more source

Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy

Journal for ImmunoTherapy of Cancer
Background The interleukin (IL)-1-family receptor antagonist IL-38 has emerged as a negative regulator of auto-inflammation. Given the intricate interplay between antitumor immunity and auto-inflammation, we hypothesized that blocking IL-38 may enhance ...
Andreas Ernst, Andreas Weigert, Priscila da Silva, Javier Mora, Xin You, Svenja Wiechmann, Mateusz Putyrski, Javier Garcia-Pardo, Aimo Kannt, Bernhard Bruene   +9 more
doaj   +1 more source