Results 21 to 30 of about 5,269 (176)
PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis [PDF]
Nature Communications, 2021 Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell ...
Thais G. Moreira +18 more
doaj +3 more sources
Shared autonomous HERV loci transcription identifies a unique circulating CD14+-xCR1+ mononuclear cell phenotype in a patient group with post-acute sequelae of COVID-19. [PDF]
PLoS ONEThe human genome contains approximately 3,200 near full-length autonomous human endogenous retroviral (HERV) loci capable of transcriptional activation through long terminal repeats.
Hyunmin Koo, Casey D Morrow
doaj +2 more sources
Expression and function of the chemokine receptor XCR1 on murine CD8 + DC [PDF]
, 2010 In dieser Arbeit wurde die Expression von XCR1 in B6XCR1lacZ+/+ Reporter Mäusen charakterisiert, die β-Galaktosidase unter der Kontrolle des XCR1-Promotors exprimieren.
Mora, Ahmed
core +3 more sources
Cell Reports, 2019 Summary: Type I interferons (IFNs) play important roles in antitumor immunity. We generated IFN-α-producing cells by genetically engineered induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs).
Itaru Endo, Azusa Miyashita, Tianyi Liu
exaly +3 more sources
Arthritis Research & Therapy, 2019 Background Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut.
Kétia Ermoza +7 more
doaj +2 more sources
Intratumoral sustained release of resiquimod with ablative fractional laser induces efficacy in a cutaneous squamous cell carcinoma mouse model [PDF]
Frontiers in ImmunologyIntroductionThe Toll-like receptor (TLR) 7/8 agonist resiquimod has shown promise for precancerous lesions of cutaneous squamous cell carcinoma (cSCC) but remains unexplored as a treatment for cSCC.
Martin Wiinberg +6 more
doaj +2 more sources
Generating and Expanding Conventional Type 1 Dendritic Cells. [PDF]
Eur J ImmunolConventional type 1 dendritic cells (cDC1s) are difficult to obtain in sufficient numbers. This Review compares strategies based on progenitor differentiation, cell programming, or expansion in tissues, and shows how differences in cell identity, population composition, function, and yield should guide platform selection.
Sharma S, Pillay S, Mayer CT.
europepmc +2 more sources
Frontiers in Immunology, 2023 Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in part via the production of the proinflammatory cytokine interleukin-12.
Cody D. Moorman +6 more
doaj +1 more source
Frontiers in Immunology, 2023 A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge
Adan Chari Jirmo +19 more
doaj +1 more source
Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Li Q +3 more
europepmc +2 more sources