Results 21 to 30 of about 4,391 (150)

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis [PDF]

Scientific Reports, 2016
Abstract Intestinal immune homeostasis requires dynamic crosstalk between innate and adaptive immune cells. Dendritic cells (DCs) exist as multiple phenotypically and functionally distinct sub-populations within tissues, where they initiate immune responses and promote homeostasis. In the gut, there exists a minor
Ohta, T, Sugiyama, M, Hemmi, H, Yamazaki, C, Okura, S, Sasaki, I, Fukuda, Y, Orimo, T, Ishii, K.J, Hoshino, K, Ginhoux, F, Kaisho, T   +11 more
openaire   +2 more sources

Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapy [PDF]

Frontiers in Immunology, 2014
Dendritic cells (DC) are professional antigen presenting cells (APCs) that play a pivotal role in the induction and regulation of immune responses, including the induction of cytotoxic T lymphocyte (CTL) responses. They are an important focus for the development of vaccines against cancers and many pathogens, including HIV and malaria, where CTL ...
Kirsteen eTullett, Kirsteen eTullett, Kirsteen eTullett, Mireille eLahoud, Mireille eLahoud, Kristen J Radford, Kristen J Radford   +6 more
doaj   +6 more sources

Cross-Presenting XCR1+ Dendritic Cells as Targets for Cancer Immunotherapy [PDF]

Cells, 2020
The use of dendritic cells (DCs) to generate effective anti-tumor T cell immunity has garnered much attention over the last thirty-plus years. Despite this, limited clinical benefit has been demonstrated thus far. There has been a revival of interest in DC-based treatment strategies following the remarkable patient responses observed with novel ...
Katherine M. Audsley, Alison M. McDonnell, Jason Waithman   +2 more
openaire   +3 more sources

Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile

Frontiers in Immunology, 2023
Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV).
Julia Cecilia Madela-Mönchinger, Silver Anthony Wolf, Emanuel Wyler, Agnieszka Bauer, Marius Mischke, Lars Möller, Vanda Juranić Lisnić, Markus Landthaler, Anna Malyshkina, Sebastian Voigt   +9 more
doaj   +1 more source

New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies

Frontiers in Immunology, 2022
Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently ...
Agata Ciechanowska, Ewelina Rojewska, Anna Piotrowska, Justyna Barut, Katarzyna Pawlik, Katarzyna Ciapała, Grzegorz Kreiner, Joanna Mika   +7 more
doaj   +1 more source

The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]

PLoS ONE, 2017
The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li, Guoyan Wei, Yimei Cao, Dong Li, Pinghua Li, Jing Zhang, Huifang Bao, Yingli Chen, Yuanfang Fu, Pu Sun, Xingwen Bai, Xueqing Ma, Zengjun Lu, Zaixin Liu   +13 more
doaj   +1 more source

Cross-presentation of cutaneous melanoma antigen by migratory XCR1⁺CD103⁻and XCR1⁺CD103⁺dendritic cells [PDF]

OncoImmunology, 2015
The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin.
Ben, Wylie, Elke, Seppanen, Kun, Xiao, Rachael, Zemek, Damien, Zanker, Sandro, Prato, Bree, Foley, Prue H, Hart, Richard A, Kroczek, Weisan, Chen, Jason, Waithman   +10 more
openaire   +2 more sources

Spatially Restricted Translation of the xCR1 mRNA in Xenopus Embryos [PDF]

Molecular and Cellular Biology, 2009
The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic cells.
Zhang, Yan, Forinash, Kara D., McGivern, Jered, Fritz, Brian, Dorey, Karel; id_orcid 0000-0003-0846-5286, Sheets, Michael D.   +5 more
openaire   +3 more sources

Identification of Single C Motif-1/Lymphotactin Receptor XCR1 [PDF]

Journal of Biological Chemistry, 1998
Single C motif-1 (SCM-1)/lymphotactin is a member of the chemokine superfamily, but retains only the 2nd and 4th of the four cysteine residues conserved in other chemokines. In humans, there are two highly homologous SCM-1 genes encoding SCM-1alpha and SCM-1beta with two amino acid substitutions.
T, Yoshida, T, Imai, M, Kakizaki, M, Nishimura, S, Takagi, O, Yoshie   +5 more
openaire   +2 more sources