Results 1 to 10 of about 5,439,323 (304)
Dendritic cell metabolism [PDF]
Nature Reviews Immunology, 2014 The past 15 years have seen enormous advances in our understanding of the receptor and signalling systems that allow dendritic cells (DCs) to respond to pathogens or other danger signals and initiate innate and adaptive immune responses. We are now beginning to appreciate that many of these pathways not only stimulate changes in the expression of genes
Bart Everts, Edward Pearce
exaly +5 more sources
Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration
Journal of Immunology ResearchDendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments.
Min-Seon Song +3 more
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Frontiers in Immunology, 2022 Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment in mice and tested its ...
Pablo A. Silveira +15 more
doaj +1 more source
Plasmacytoid dendritic cells: A dendritic cell in disguise
Molecular Immunology, 2023 Since their discovery, the identity of plasmacytoid dendritic cells (pDCs) has been at the center of a continuous dispute in the field, and their classification as dendritic cells (DCs) has been recently re-challenged. pDCs are different enough from the rest of the DC family members to be considered a lineage of cells on their own. Unlike the exclusive
Rebeca Arroyo Hornero, Juliana Idoyaga
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Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models
Frontiers in Immunology, 2023 Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that can increase DC abundance in the tumor when administered therapeutically.
Emile J. Clappaert +25 more
doaj +1 more source
Dendritic Cells Revisited [PDF]
Annual Review of Immunology, 2021 Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes.
Cabeza-Cabrerizo, Mar +4 more
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Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody
Clinical & Translational Immunology, 2020 Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li +11 more
doaj +1 more source
Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy
Pharmaceutics, 2020 The onset of checkpoint inhibition revolutionized the treatment of cancer. However, studies from the last decade suggested that the sole enhancement of T cell functionality might not suffice to fight malignancies in all individuals. Dendritic cells (DCs)
Lukas Amon +4 more
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The Cancer Journal, 2010 Cancer vaccines have undergone a renaissance because of recent clinical trials showing promising immunologic data and some clinical benefit to patients. Current trials exploiting dendritic cells (DCs) as vaccines have shown durable tumor regressions in a fraction of patients.
Karolina, Palucka +4 more
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Neoplasia: An International Journal for Oncology Research, 2005 Dendritic cells (DC) have been implicated in the defective function of the immune system during cancer progression. We have demonstrated that patients with cancer have fewer myeloid (CD11c+) and plasmacytoid (CD123hi) DC and a concurrent accumulation of ...
Alberto Pinzon-Charry +5 more
doaj +1 more source