Results 11 to 20 of about 764,211 (312)

Dendritic cell metabolism [PDF]

Nature Reviews Immunology, 2014
The past 15 years have seen enormous advances in our understanding of the receptor and signalling systems that allow dendritic cells (DCs) to respond to pathogens or other danger signals and initiate innate and adaptive immune responses. We are now beginning to appreciate that many of these pathways not only stimulate changes in the expression of genes
Pearce, E.J., Everts, B.
openaire   +6 more sources

Emerging frontiers in the mitochondrial regulation of dendritic cell biology [PDF]

Redox Biology
Dendritic Cells are central players of our immune system, linking innate sensing to adaptive immunity through antigen presentation and T cell priming. Beyond transcriptional and cytokine-based regulation, mitochondria are emerging as potential regulators
B. Chen, J.U. Mayer
doaj   +2 more sources

Anti-Mouse CD83 Monoclonal Antibody Targeting Mature Dendritic Cells Provides Protection Against Collagen Induced Arthritis

Frontiers in Immunology, 2022
Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment in mice and tested its ...
Pablo A. Silveira, Pablo A. Silveira, Fiona Kupresanin, Adelina Romano, Wei-Hsun Hsu, Wei-Hsun Hsu, Tsun-Ho Lo, Xinsheng Ju, Xinsheng Ju, Hsiao-Ting Chen, Hsiao-Ting Chen, Helen Roberts, Daniel G. Baker, Georgina J. Clark, Georgina J. Clark, Georgina J. Clark   +15 more
doaj   +1 more source

Dendritic Cells Revisited [PDF]

Annual Review of Immunology, 2021
Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes.
Cabeza-Cabrerizo, Mar, Cardoso, Ana, Minutti, Carlos M., Pereira da Costa, Mariana, Reis e Sousa, Caetano   +4 more
openaire   +2 more sources

Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

Frontiers in Immunology, 2023
Conventional dendritic cells (cDCs) are at the forefront of activating the immune system to mount an anti-tumor immune response. Flt3L is a cytokine required for DC development that can increase DC abundance in the tumor when administered therapeutically.
Emile J. Clappaert, Emile J. Clappaert, Emile J. Clappaert, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Jan Brughmans, Jan Brughmans, Ayla Debraekeleer, Ayla Debraekeleer, Pauline M. R. Bardet, Pauline M. R. Bardet, Yvon Elkrim, Yvon Elkrim, Dagmar Lacroix, Dagmar Lacroix, Maida Živalj, Maida Živalj, Ahmed E.I. Hamouda, Ahmed E.I. Hamouda, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Sofie Deschoemaeker, Sofie Deschoemaeker, Damya Laoui, Damya Laoui   +25 more
doaj   +1 more source

Exact solutions to cable equations in branching neurons with tapering dendrites [PDF]

, 2020
Neurons are biological cells with uniquely complex dendritic morphologies that are not present in other cell types. Electrical signals in a neuron with branching dendrites can be studied by cable theory which provides a general mathematical modelling ...
Timofeeva, Yulia, Yihe, Lu
core   +3 more sources

Intestinal dendritic cells [PDF]

Current Opinion in Gastroenterology, 2015
The intestinal immune system is constantly exposed to foreign antigens, which for the most part should be tolerated, but the immune system retains the ability to react rapidly and effectively to eliminate pathogens. Dendritic cells are at the front line in maintaining intestinal integrity as they are widely distributed within the intestinal lamina ...
Schiavi Elisa, Smolinska Sylwia, O'Mahony Liam   +2 more
openaire   +4 more sources

Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody

Clinical & Translational Immunology, 2020
Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li, Edward Abadir, Kenneth Lee, Candice Clarke, Christian E Bryant, Wendy Cooper, Geoffrey Pietersz, James Favaloro, Pablo A Silveira, Derek NJ Hart, Xinsheng Ju, Georgina J Clark   +11 more
doaj   +1 more source

Tolerogenic Dendritic Cells [PDF]

Annual Review of Immunology, 2003
▪ Abstract  Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells.
Steinman, Ralph M., Hawiger, Daniel, Nussenzweig, Michel C.   +2 more
openaire   +2 more sources

Computational convergence of the path integral for real dendritic morphologies [PDF]

, 2012
Neurons are characterised by a morphological structure unique amongst biological cells, the core of which is the dendritic tree. The vast number of dendritic geometries, combined with heterogeneous properties of the cell membrane, continue to challenge ...
Brand, Samuel, Caudron, Quentin, Donnelly, Simon R., Timofeeva, Yulia   +3 more
core   +2 more sources