Results 31 to 40 of about 764,211 (312)
Putative cell adhesion membrane protein Vstm5 regulates neuronal morphology and migration in the central nervous system [PDF]
, 2016 During brain development, dynamic changes in neuronal membranes perform critical roles in neuronal morphogenesis and migration to create functional neural circuits.
Ko, Kwang Woo +5 more
core +2 more sources
CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma
Haematologica, 2018 Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disease ...
Ziduo Li +21 more
doaj +1 more source
Frontiers in Oncology, 2019 Monoclonal antibodies targeting co-inhibitory immune checkpoint molecules have been successful in clinical trials of both solid and hematological malignancies as acknowledged by the 2018 Nobel Prize in Medicine, however improving clinical response rates ...
Benjamin Y. Kong +12 more
doaj +1 more source
IOX1 impedes host inflammation in imiquimod-triggered psoriasis
Heliyon, 2021 Psoriasis is a chronic autoimmune disease with an unknown etiology and highly limited treatment strategies. The drugs currently used in the treatment of psoriasis are rarely recommended for long-term use owing to the serious side effects.
Joo Eun Shin +4 more
doaj +1 more source
Dendritic Cells-Nature and Classification
Allergology International, 2007 Dendritic cells (DCs) are antigen (Ag)-presenting cells (APCs) characterized by a unique capacity to stimulate naïve T cells and initiate primary immune responses.
Katsuaki Sato, Shigeharu Fujita
doaj +1 more source
A novel myeloid cell in murine spleen defined through gene profiling [PDF]
, 2019 A novel myeloid antigen presenting cell can be generated through in vitro haematopoiesis in long-term splenic stromal cocultures. The in vivo equivalent subset was recently identified as phenotypically and functionally distinct from the spleen subsets of
Dabiri GA +5 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2005 Dendritic cell (DC) defects are an important component of immunosuppression in cancer. Here, we assessed whether cancer could affect circulating DC populations and its correlation with tumor progression.
Alberto Pinzon-Charry +10 more
doaj +1 more source
Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor [PDF]
, 2016 Although it is successful for some, most melanoma patients are refractory to T cell checkpoint inhibition. In this issue of Immunity, Merad and colleagues (2016) describe a dendritic-cell-based strategy to heighten the efficacy of therapeutic anti-PD-L1 ...
Coffelt, Seth B., de Visser, Karin E.
core +1 more source
A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo [PDF]
, 2018 Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity.
Baz Morelli, Adriana +10 more
core +3 more sources
Tetanic Stimulation Leads to Increased Accumulation of Ca^(2+)/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons [PDF]
, 1999 mRNA for the ɑ-subunit of CaMKII is abundant in dendrites of neurons in the forebrain (Steward, 1997). Here we show that tetanic stimulation of the Schaffer collateral pathway causes an increase in the concentration of ɑ-CaMKII in the dendrites of ...
Kennedy, Mary B. +4 more
core +1 more source