Results 21 to 30 of about 5,794,222 (305)

CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation

Molecular Oncology, 2019
Antibody‐based therapy in acute myeloid leukemia (AML) has been marred by significant hematologic toxicity due to targeting of both hematopoietic stem and progenitor cells (HSPCs).
Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark   +14 more
doaj   +1 more source

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

Frontiers in Immunology, 2019
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Ziduo Li, Ziduo Li, Xinsheng Ju, Xinsheng Ju, Pablo A. Silveira, Pablo A. Silveira, Edward Abadir, Edward Abadir, Wei-Hsun Hsu, Wei-Hsun Hsu, Derek N. J. Hart, Derek N. J. Hart, Georgina J. Clark, Georgina J. Clark   +13 more
doaj   +1 more source

Moving on From Sipuleucel-T: New Dendritic Cell Vaccine Strategies for Prostate Cancer

Frontiers in Immunology, 2021
Tumors evade the immune system though a myriad of mechanisms. Using checkpoint inhibitors to help reprime T cells to recognize tumor has had great success in malignancies including melanoma, lung, and renal cell carcinoma.
Sarah I. M. Sutherland, Sarah I. M. Sutherland, Sarah I. M. Sutherland, Sarah I. M. Sutherland, Xinsheng Ju, Xinsheng Ju, L. G. Horvath, L. G. Horvath, L. G. Horvath, Georgina J. Clark, Georgina J. Clark   +10 more
doaj   +1 more source

CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma

Haematologica, 2018
Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disease ...
Ziduo Li, Xinsheng Ju, Kenneth Lee, Candice Clarke, Jennifer L. Hsu, Edward Abadir, Christian E. Bryant, Suzanne Pears, Neroli Sunderland, Scott Heffernan, Annemarie Hennessy, Tsun-Ho Lo, Geoffrey A. Pietersz, Fiona Kupresanin, Phillip D. Fromm, Pablo A. Silveira, Con Tsonis, Wendy A. Cooper, Ilona Cunningham, Christina Brown, Georgina J. Clark, Derek N.J. Hart   +21 more
doaj   +1 more source

The dendritic density field of a cortical pyramidal cell [PDF]

, 2012
Much is known about the computation in individual neurons in the cortical column. Also, the selective connectivity between many cortical neuron types has been studied in great detail.
Hermann Cuntz, Cuntz, H. ; https://orcid.org/, Cuntz, Hermann, Hermann eCuntz   +3 more
core   +1 more source

On the Other Side: Manipulating the Immune Checkpoint Landscape of Dendritic Cells to Enhance Cancer Immunotherapy

Frontiers in Oncology, 2019
Monoclonal antibodies targeting co-inhibitory immune checkpoint molecules have been successful in clinical trials of both solid and hematological malignancies as acknowledged by the 2018 Nobel Prize in Medicine, however improving clinical response rates ...
Benjamin Y. Kong, Benjamin Y. Kong, Benjamin Y. Kong, Holly Bolton, Holly Bolton, Julius W. Kim, Julius W. Kim, Pablo A. Silveira, Pablo A. Silveira, Phillip D. Fromm, Phillip D. Fromm, Georgina J. Clark, Georgina J. Clark   +12 more
doaj   +1 more source

The disabled dendritic cell [PDF]

The FASEB Journal, 2001
ABSTRACT Dendritic cells are important antigen‐presenting cells of the immune system that induce and modulate immune responses. They interact with T and B lymphocytes as well as with natural killer cells to promote activation and differentiation of these cells.
M, Thurnher, C, Zelle-Rieser, R, Ramoner, G, Bartsch, L, Höltl   +4 more
openaire   +2 more sources

Therapeutic dendritic cell vaccination against human papillomavirus [PDF]

, 2009
Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually.
Nurkkala Karlsson, Merja
core   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Lei, Y., Jeker, L. T., Georg A. Holländer, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Nagasawa, T., Izumi Ohigashi, Ripen, A. M., Ohigashi, I., Takashi Nagasawa, Malefyt Rde, W., Adiratna Mat Ripen, Nitta, Takeshi, Ripen, Adiratna Mat, Bösl, Michael R., Lei, Yu, de Waal Malefyt, Rene, Jeker, Lukas T., Ishimaru, Naozumi, Hayashi, Yoshio, Takahama, Yousuke, Ohigashi, Izumi, Nagasawa, Takashi, Holländer, Georg A.   +35 more
core   +1 more source

Intestinal dendritic cells [PDF]

Current Opinion in Gastroenterology, 2015
PURPOSE OF REVIEW The intestinal immune system is constantly exposed to foreign antigens, which for the most part should be tolerated, but the immune system retains the ability to react rapidly and effectively to eliminate pathogens. Dendritic cells are at the front line in maintaining intestinal integrity as they are widely distributed within the ...
Schiavi Elisa, Smolinska Sylwia, O'Mahony Liam   +2 more
openaire   +5 more sources