Results 1 to 10 of about 16,344 (174)

The CD83 Molecule – An Important Immune Checkpoint

Frontiers in Immunology, 2020
The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Heinrich Sticht, Alexander Steinkasserer, Ilka Knippertz   +2 more
exaly   +5 more sources

Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody [PDF]

Clinical & Translational Immunology, 2020
Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li, Edward Abadir, Kenneth Lee, Candice Clarke, Christian E Bryant, Wendy Cooper, Geoffrey Pietersz, James Favaloro, Pablo A Silveira, Derek NJ Hart, Xinsheng Ju, Georgina J Clark   +11 more
doaj   +4 more sources

The role of CD83 in the pathogenesis of immune thrombocytopenia

Hematology
Background CD83 are closely related to the pathogenesis of immune thrombocytopenia (ITP), but the exact mechanism remains unclear.Aim To explore the relationship between CD83 and CD4+ T cell subsets and clarify the role of CD83 in the pathogenesis of ITP.
Xiuli Wang, Qiyuan Zhou, Wen Yang, Hui Bi, Honghui Wang, Yacan Wang, Yadong Du, Lin Liu, Yuebo Liu, Liefen Yin, Jin Yao, Jingxing Yu, Wei Tao, Yongchun Zhou, Zeping Zhou   +14 more
doaj   +3 more sources

Pan-cancer single-cell transcriptomic analysis reveals CD83 as a hallmark of tumor-associated neutrophils with senescent and pro-tumor properties [PDF]

Computational and Structural Biotechnology Journal
Neutrophils, the most prevalent and efficient immune responders to pathogens, play vital roles in tumor progression and metastasis. Sustained neutrophil infiltration into tumor has been consistently linked to unfavorable clinical outcomes. Despite recent
Yimin Wang, Yuan Meng, Kanchao Chen, Aihua Li, Jinqiang Yan, Jie Ding, Bingwu Yang, Linlin Tang, Bin Ding, Siyuan Chen, Song Chen, Fengyu Chen, Tong Chen, Yan Zhang, Qin Zheng, Chao Chen, Sizhou Feng   +16 more
doaj   +2 more sources

CD83 in Hodgkin lymphoma

Haematologica, 2018
The development of combined chemotherapy with or without radiotherapy for classical Hodgkin lymphoma (HL) can be considered as a major success story in onocology. With current treatment protocols, a long-term cure is obtained in about 80-90% of patients.[1][1] However, these therapies come ...
Ralf Küppers
doaj   +4 more sources

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

Frontiers in Immunology, 2019
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Pablo A Silveira, Georgina Clark, Xinsheng Ju   +2 more
exaly   +3 more sources

CD83 Regulates the Immune Responses in Inflammatory Disorders

International Journal of Molecular Sciences, 2023
Activating the immune system plays an important role in maintaining physiological homeostasis and defending the body against harmful infections. However, abnormalities in the immune response can lead to various immunopathological responses and severe inflammation.
Seonghyang Sohn, S M Shamsul Islam, Hye-Myung Ryu   +2 more
exaly   +3 more sources

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Alexander Steinkasserer, Ilka Knippertz, Elisabeth Zinser   +2 more
exaly   +3 more sources

Molecular cloning and characterization of duck CD83 and its effect on H9N2 avian influenza virus replication [PDF]

Poultry Science
Cluster of Differentiation 83 (CD83) is a multifunctional regulatory molecule that has been identified in several mammals, birds, and fishes; however, no reports have described CD83 in ducks to date.
Huinan Li, Xiaojing Xin, Zhe Yin, Chao Dong, Feng Li, Yujing Liu, Xinru Kong, Liyue Wang, Juan Wang, Fei Yu, Shanshan Huo   +10 more
doaj   +2 more sources

Dendritic cell CD83: A therapeutic target or innocent bystander? [PDF]

Immunology Letters, 2008
CD83 represents an intriguing target for immunotherapy due to its preferential expression on mature DCs, the most efficient of antigen presenting cells. Based on its restricted expression pattern, structure, and the paucity of CD4+ T cells in CD83-deficient mice, multiple immunologically important functions for CD83 during immune responses have been ...
Thomas Tedder
exaly   +3 more sources