Results 1 to 10 of about 20,106 (166)

The CD83 Molecule – An Important Immune Checkpoint

Frontiers in Immunology, 2020
The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Heinrich Sticht, Alexander Steinkasserer, Ilka Knippertz   +2 more
exaly   +4 more sources

CD83 CAR T provides an alternative strategy to CD19-targeting in B cell malignancies [PDF]

Journal for ImmunoTherapy of Cancer
Background Chimeric antigen receptor T cells (CAR T) targeting CD19 can cure patients with aggressive B cell malignancies. Relapse due to CD19 loss and infections from B cell aplasia remain major causes of death after CD19 CAR T. We demonstrate that CD83
Frederick L Locke, Anne Eaton, Renier J Brentjens, Marco L Davila, Shernan G Holtan, Constanza Savid-Frontera, Duna Massillon, Brian Christopher Betts, Shannon McSain, Kelly Walton, Eliese Maybee, Nolan Beatty, Payal Goala, Isaac M Spiegel, Michael A Linden, Meredith L Stone   +15 more
doaj   +2 more sources

CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation [PDF]

Frontiers in Immunology, 2023
Excessive macrophage (Mφ) activation results in chronic inflammatory responses or autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which contribute to resolution of inflammation, is crucial for the development of new ...
Katrin Peckert-Maier, Pia Langguth, Astrid Strack, Lena Stich, Petra Mühl-Zürbes, Christine Kuhnt, Christina Drassner, Elisabeth Zinser, Marius Wrage, Jochen Mattner, Alexander Steinkasserer, Dmytro Royzman, Andreas B. Wild   +12 more
doaj   +2 more sources

Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis [PDF]

Nature Communications, 2023
Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia determines the severity of neuro-inflammatory diseases.
Pia Sinner, Katrin Peckert-Maier, Hashem Mohammadian, Christine Kuhnt, Christina Draßner, Vasiliki Panagiotakopoulou, Simon Rauber, Mathias Linnerbauer, Zhana Haimon, Dmytro Royzman, Deborah Kronenberg-Versteeg, Andreas Ramming, Alexander Steinkasserer, Andreas B. Wild   +13 more
doaj   +2 more sources

Genetic and cross-species single-cell analyses prioritize CD83 in antigen-presenting cells as a candidate therapeutic target in asthma [PDF]

Frontiers in Immunology
BackgroundAsthma remains a heterogeneous inflammatory airway disease, and current therapies, including biologics, benefit only selected patient subsets.
Guojun Qian, Qiaoyi Xu, Xuejiao Zhu, Yiying Tao, Xibing Ding, Hao Zhu, Song Zhang, Qionghui Zhan, Saihong Xu, Yan Song, Qin Hu, Hongwei Fang, Yinghui Fan, Jie Tian, Weifeng Yu   +14 more
doaj   +2 more sources

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

Frontiers in Immunology, 2019
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Pablo Silveira, Georgina Clark, Xinsheng Ju   +2 more
exaly   +3 more sources

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Alexander Steinkasserer, Ilka Knippertz, Elisabeth Zinser   +2 more
exaly   +3 more sources

Pan-cancer single-cell transcriptomic analysis reveals CD83 as a hallmark of tumor-associated neutrophils with senescent and pro-tumor properties [PDF]

Computational and Structural Biotechnology Journal
Neutrophils, the most prevalent and efficient immune responders to pathogens, play vital roles in tumor progression and metastasis. Sustained neutrophil infiltration into tumor has been consistently linked to unfavorable clinical outcomes. Despite recent
Yimin Wang, Yuan Meng, Kanchao Chen, Aihua Li, Jinqiang Yan, Jie Ding, Bingwu Yang, Linlin Tang, Bin Ding, Siyuan Chen, Song Chen, Fengyu Chen, Tong Chen, Yan Zhang, Qin Zheng, Chao Chen, Sizhou Feng   +16 more
doaj   +2 more sources

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy

Journal of Innate Immunity, 2021
The mechanism of generation of antigen-specific regulatory T cells (Treg) is not fully understood yet. This study aimed to investigate the role of intestinal epithelial cell (IEC)-derived CD83 in the Treg generation in the intestine.
Yong Yu, Qiao-Ruo Jin, Yang Mi, Jiang-Qi Liu, Zhi-Qiang Liu, Shuai Wang, Zhi-Gang Liu, Ping-Chang Yang, Peng-Yuan Zheng   +8 more
doaj   +1 more source