Results 31 to 40 of about 26,169 (207)

Inhibition of Cd83 Cell Surface Expression during Dendritic Cell Maturation by Interference with Nuclear Export of Cd83 mRNA [PDF]

The Journal of Experimental Medicine, 2000
Dendritic cells (DCs), nature's adjuvant, must mature to sensitize T cells. However, although the maturation process is essential, it is not yet fully understood at the molecular level. In this study, we investigated the course of expression of the unique hypusine-containing protein eukaryotic initiation factor 5A (eIF-5A), which is part of a ...
M, Kruse, O, Rosorius, F, Krätzer, D, Bevec, C, Kuhnt, A, Steinkasserer, G, Schuler, J, Hauber   +7 more
openaire   +2 more sources

Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza

npj Vaccines, 2021
The immunogenicity and protective efficacy of vaccines can be enhanced by the selective delivery of antigens to the antigen-presenting cells (APCs).
Angita Shrestha, Jean-Remy Sadeyen, Deimante Lukosaityte, Pengxiang Chang, Adrian Smith, Marielle Van Hulten, Munir Iqbal   +6 more
doaj   +1 more source

CD83 expression induced by CpG-DNA stimulation in a macrophage cell line RAW 264.7 [PDF]

BMB Reports, 2013
CpG-DNA has various immunomodulatory effects in dendriticcells, B cells, and macrophages. While induction of cytokinesby CpG-DNA has been well documented in macrophages, theexpression of costimulatory molecules in CpG-DNA treatedmacrophages has not yet ...
Min Chul Park, Dongbum Kim, Younghee Lee, Hyung-Joo Kwon   +3 more
doaj   +1 more source

IL-18–induced CD83+CCR7+NK helper cells [PDF]

The Journal of Experimental Medicine, 2005
In addition to their cytotoxic activities, natural killer (NK) cells can have immunoregulatory functions. We describe a distinct “helper” differentiation pathway of human CD56+CD3− NK cells into CD56+/CD83+/CCR7+/CD25+ cells that display high migratory responsiveness to lymph node (LN)–associated chemokines, high ability to produce interferon-γ upon ...
Mailliard, Robbie B., Alber, Sean M., Shen, Hongmei, Watkins, Simon C., Kirkwood, John M., Herberman, Ronald B., Kalinski, Pawel   +6 more
openaire   +2 more sources

Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Behçet’s Disease Model Mouse

Mediators of Inflammation, 2019
Behçet’s disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways.
S. M. Shamsul Islam, Hae-Ok Byun, Bunsoon Choi, Seonghyang Sohn   +3 more
doaj   +1 more source

The role of Microenvironment in tumorigenesis. Focus on dendritic cells in human papillomavirus E6, E7-transformed keratinocytes [PDF]

, 2015
The inception of tumor microenvironment (TME), a complex and dynamic system constituted by different types of cells engaged by tumor and extracellular matrix surrounding cancer cells, is a way for them to elude the immune surveillance.
Accardi, Rosita, CHIANTORE, Maria Vincenza, Fiorucci, Gianna, IULIANO, MARCO, MANGINO, GIORGIO, ROMEO, Giovanna, Tommasino, Massimo   +6 more
core   +1 more source

Post-transcriptional regulation of CD83 expression by AUF1 proteins [PDF]

Nucleic Acids Research, 2012
Mature dendritic cells (DC), activated lymphocytes, mononuclear cells and neutrophils express CD83, a surface protein apparently necessary for effective DC-mediated activation of naïve T-cells and T-helper cells, thymic T-cell maturation and the regulation of B-cell activation and homeostasis.
Ehlers, Christina, Schirmer, Susann, Kehlenbach, Ralph H., Hauber, Joachim, Chemnitz, Jan   +4 more
openaire   +3 more sources

CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.

PLoS ONE, 2007
The murine transmembrane glycoprotein CD83 is an important regulator for both thymic T cell maturation and peripheral T cell responses. Recently, we reported that CD83 also has a function on B cells: Ubiquitous transgenic (Tg) expression of CD83 ...
Birte Kretschmer, Katja Lüthje, Andreas H Guse, Svenja Ehrlich, Friedrich Koch-Nolte, Friedrich Haag, Bernhard Fleischer, Minka Breloer   +7 more
doaj   +1 more source

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]

, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda, A Soloaga, A Sommer, Andrew Wingate, B Echtenacher, B Echtenacher, BG Stiles, C Platzer, CA Gogos, Claire E Monk, Claus Johansen, D Rittirsch, DM Dambach, ER Ottosen, F Hildebrand, FY Liew, GR Wiggin, GY Song, H Chi, J Bain, J Darragh, J Han, J Rouse, J Simon C Arthur, Jin Mo Park, JM Park, Joanne Darragh, Joanne McIlrath, JS Arthur, JS Arthur, Julia M Carr, KV Salojin, Lars Iversen, M Brook, M Hammer, M Saraiva, ML Steinhauser, MS Lee, NC Riedamann, NW Freshney, Olga Ananieva, OM Peck-Palmer, P Chen, PC Cheung, PJ Murray, Q Zhao, R Kuhn, Rachel Toth, SE Moreno, SJ O'Keefe, SM Miggin, SQ Latifi, Susana G Santos, T Kawai, T Lang, T van der Poll, VA Beardmore, VS Carl, WJ Hubbard, X Zhang, Y Kalechman, YJ Kang   +61 more
core   +3 more sources

Activation-induced expression of murine CD83 on T cells and identification of a specific CD83 ligand on murine B cells [PDF]

International Immunology, 2000
Human CD83 is a cell surface protein expressed predominantly by dendritic cells (DC) and lymphoid cells. So far, there exists no information on the function and distribution of mCD83. Here we demonstrate that mCD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells following activation with antigenic ...
S O, Cramer, C, Trumpfheller, U, Mehlhoop, S, Moré, B, Fleischer, A, von Bonin   +5 more
openaire   +2 more sources