Results 11 to 20 of about 26,169 (207)
Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody [PDF]
Clinical & Translational Immunology, 2020 Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li +11 more
doaj +4 more sources
The CD83 Molecule – An Important Immune Checkpoint
Frontiers in Immunology, 2020 The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Linda Grosche +9 more
doaj +3 more sources
Haematologica, 2018 The development of combined chemotherapy with or without radiotherapy for classical Hodgkin lymphoma (HL) can be considered as a major success story in onocology. With current treatment protocols, a long-term cure is obtained in about 80-90% of patients.[1][1] However, these therapies come ...
Ralf Küppers
doaj +4 more sources
CD83 polymorphisms and cervical cancer risk [PDF]
Gynecologic Oncology, 2009 Studies have suggested that polymorphisms in genes involved in immune recognition and antigen presentation are associated with cervical cancer risk. We sought to replicate a recent study which reported an association between specific SNPs on CD83 and cervical cancer and to further explore whether effects varied by age, clinical stage (in situ versus ...
Kelly J, Yu +4 more
openaire +2 more sources
Immunological characteristics of dendritic cells marker CD83 in flounder (Paralichthys olivaceus)
Fish and Shellfish Immunology Reports, 2021 Dendritic cells (DCs) are the professional antigen presenting cells, which play important roles in regulating the immune response and tolerance. In mammals, CD83 is considered as a maturation marker for DCs, which is a type I membrane glycoprotein.
Fujing Dong +6 more
doaj +1 more source
CD83 expression characterizes precursor exhausted T cell population
Communications Biology, 2023 AbstractT cell exhaustion is a main obstacle against effective cancer immunotherapy. Exhausted T cells include a subpopulation that maintains proliferative capacity, referred to as precursor exhausted T cells (TPEX). While functionally distinct and important for antitumor immunity, TPEX possess some overlapping phenotypic features with the other T-cell
Zhiwen Wu +10 more
openaire +3 more sources
Frontiers in Immunology, 2023 Excessive macrophage (Mφ) activation results in chronic inflammatory responses or autoimmune diseases. Therefore, identification of novel immune checkpoints on Mφ, which contribute to resolution of inflammation, is crucial for the development of new ...
Katrin Peckert-Maier +12 more
doaj +1 more source
Frontiers in Immunology, 2022 Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment in mice and tested its ...
Pablo A. Silveira +15 more
doaj +1 more source
Soluble CD83 ameliorates experimental colitis in mice [PDF]
Mucosal Immunology, 2014 The physiological balance between pro- and anti-inflammatory processes is dysregulated in inflammatory bowel diseases (IBD) as in Crohn's disease and ulcerative colitis. Conventional therapy uses anti-inflammatory and immunosuppressive corticosteroids to treat acute-phase symptoms.
J, Eckhardt +13 more
openaire +2 more sources
CD83 Regulates the Immune Responses in Inflammatory Disorders
International Journal of Molecular Sciences, 2023 Activating the immune system plays an important role in maintaining physiological homeostasis and defending the body against harmful infections. However, abnormalities in the immune response can lead to various immunopathological responses and severe inflammation.
Bushra Riaz +3 more
openaire +2 more sources