CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma [PDF]
Haematologica, 2018 Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disease ...
Ziduo Li +21 more
doaj +3 more sources
The role of CD83 in the pathogenesis of immune thrombocytopenia
HematologyBackground CD83 are closely related to the pathogenesis of immune thrombocytopenia (ITP), but the exact mechanism remains unclear.Aim To explore the relationship between CD83 and CD4+ T cell subsets and clarify the role of CD83 in the pathogenesis of ITP.
Xiuli Wang +14 more
doaj +2 more sources
Targeting CD83 in mantle cell lymphoma with anti‐human CD83 antibody [PDF]
Clinical & Translational Immunology, 2020 Objectives Effective antibody–drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma.
Ziduo Li +11 more
doaj +2 more sources
Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Behçet’s Disease Model Mouse [PDF]
Mediators of Inflammation, 2019 Behçet’s disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways.
S. M. Shamsul Islam +3 more
doaj +2 more sources
Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83
Frontiers in Immunology, 2021 The purpose of this study was to determine whether administration of the microorganism Eubacterium rectale (E. rectale) could regulate dendritic cell (DC) activation and systemic inflammation in herpes simplex virus type 1-induced Behçet’s disease (BD ...
S. M. Shamsul Islam +9 more
doaj +2 more sources
A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice [PDF]
Frontiers in Immunology, 2017 For the normal development of pregnancy, a balance between immune tolerance and defense is crucial. However, the mechanisms mediating such a balance are not fully understood.
Damián Oscar Muzzio +5 more
doaj +2 more sources
Tolerogenic Programming Promotes Human Cytomegalovirus Permissiveness in Dendritic Cells. [PDF]
Eur J ImmunolTolerogenic programming renders dendritic cells more permissive to HCMV infection and limits their capacity to stimulate T cells. These findings suggest that tolerogenic DCs serve as a permissive cellular niche that may facilitate HCMV immune evasion. ABSTRACT Dendritic cells (DCs) are important targets of human cytomegalovirus (HCMV), yet the factors ...
Rahmel-Stein K +5 more
europepmc +2 more sources
Frontiers in Immunology, 2022 Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment in mice and tested its ...
Pablo A. Silveira +15 more
doaj +1 more source
Immunological characteristics of dendritic cells marker CD83 in flounder (Paralichthys olivaceus)
Fish and Shellfish Immunology Reports, 2021 Dendritic cells (DCs) are the professional antigen presenting cells, which play important roles in regulating the immune response and tolerance. In mammals, CD83 is considered as a maturation marker for DCs, which is a type I membrane glycoprotein.
Fujing Dong +6 more
doaj +1 more source
Functional characterization of the HuR:CD83 mRNA interaction. [PDF]
PLoS ONE, 2011 Maturation of dendritic cells (DC) is characterized by expression of CD83, a surface protein that appears to be necessary for the effective activation of naïve T-cells and T-helper cells by DC. Lately it was shown that CD83 expression is regulated on the
Dorothea Pieper +5 more
doaj +1 more source