Results 41 to 50 of about 20,106 (166)

Involvement of membrane CD83 / soluble CD83 in autoimmune pemphigus

, 2022
Le pemphigus est un groupe hétérogène de maladies bulleuses auto-immunes intra-épithéliales où les lymphocytes B produisent des auto-anticorps pathogènes directement responsables des lésions bulleuses et érosives, cutanées et muqueuses.
Bohelay, Gérôme
core  

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Pregnancy-related factors induce immune tolerance through regulation of sCD83 release

Frontiers in Immunology
A well-balanced maternal immune system is crucial to maintain fetal tolerance in case of infections during pregnancy. Immune adaptations include an increased secretion of soluble mediators to protect the semi-allogeneic fetus from excessive pro ...
Pauline Krupa, Hannah Wein, Lea Sophie Zemmrich, Marek Zygmunt, Damián Oscar Muzzio   +4 more
doaj   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83 [PDF]

, 2016
Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs thymic CD4 T cell selection. CD83 can exert cell-intrinsic and –extrinsic functions through discrete protein domains, but it remains unclear how CD83’s capacity to operate through ...
Ishido, Satoshi, Steinkasserer, Alexander, Ploegh, Hidde, Ludger Klein, Krzyzak, Lena, Petrozziello, Elisabetta, Nedjic, Jelena, Julia von Rohrscheidt, Lena Krzyzak, Christine Federle, Satoshi Ishido, Jelena Nedjic, Hidde L. Ploegh, Federle, Christine, Klein, Ludger, von Rohrscheidt, Julia, Alexander Steinkasserer, Elisabetta Petrozziello   +17 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2

, 2011
CD83 is commonly known as a specific marker for mature dendritic cells. It has been shown to be important for CD4 + T-cell development in the thymus.
Chao Gao, Liwen Chen, Yibei Zhu, Guangbo Zhang, Weixue Zhong, Xueguang Zhang   +5 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

CD83 is upregulated on activated B cells.

, 2013
C57BL/6 mice derived spleen cells (2×106/ml) were stimulated with anti-BCR (1 µg/ml) and IL-4 (20 ng/ml) or with LPS (10 µg/ml) as indicated in the headline. Cells were triple stained for CD19, CD83 and CD69 at the indicated time points.
Bernhard Fleischer (78014), Friedrich Haag (78013), Birte Kretschmer (78009), Katja Lüthje (78010), Svenja Ehrlich (78012), Minka Breloer (78015), Andreas H. Guse (78011), Friedrich Koch-Nolte (66517)   +7 more
core   +1 more source

Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens

npj Vaccines, 2022
Maternally derived antibodies (MDAs) are important for protecting chickens against pathogens in the neonatal stage however, they often interfere with vaccine performance.
Angita Shrestha, Rick Meeuws, Jean-Remy Sadeyen, Pengxiang Chang, Marielle Van Hulten, Munir Iqbal   +5 more
doaj   +1 more source