Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers [PDF]
Cells, 2019 Nucleated teleost red blood cells (RBCs) are known to express molecules from the major histocompatibility complex and peptide-generating processes such as autophagy and proteasomes, but the role of RBCs in antigen presentation of viruses have not been ...
Ivan Nombela +10 more
doaj +9 more sources
Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza [PDF]
npj Vaccines, 2021 The immunogenicity and protective efficacy of vaccines can be enhanced by the selective delivery of antigens to the antigen-presenting cells (APCs).
Angita Shrestha +6 more
doaj +6 more sources
Genetic and cross-species single-cell analyses prioritize CD83 in antigen-presenting cells as a candidate therapeutic target in asthma [PDF]
Frontiers in ImmunologyBackgroundAsthma remains a heterogeneous inflammatory airway disease, and current therapies, including biologics, benefit only selected patient subsets.
Guojun Qian +14 more
doaj +3 more sources
CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential [PDF]
Frontiers in Immunology, 2019 CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Ziduo Li +13 more
doaj +5 more sources
CD83 CAR T provides an alternative strategy to CD19-targeting in B cell malignancies [PDF]
Journal for ImmunoTherapy of CancerBackground Chimeric antigen receptor T cells (CAR T) targeting CD19 can cure patients with aggressive B cell malignancies. Relapse due to CD19 loss and infections from B cell aplasia remain major causes of death after CD19 CAR T. We demonstrate that CD83
Frederick L Locke +15 more
doaj +2 more sources
npj Vaccines, 2022 Maternally derived antibodies (MDAs) are important for protecting chickens against pathogens in the neonatal stage however, they often interfere with vaccine performance.
Angita Shrestha +5 more
doaj +3 more sources
Decreased CD1a + and CD83 + cells in tonsillar squamous cell carcinoma regardless of HPV status [PDF]
Journal of Applied Oral Science, 2022 Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in the immune response against human papillomavirus (HPV) infection, and represent a therapeutic target in cancer.
Ana Guadalupe Gama-Cuellar +5 more
doaj +1 more source
Journal of Innate Immunity, 2021 The mechanism of generation of antigen-specific regulatory T cells (Treg) is not fully understood yet. This study aimed to investigate the role of intestinal epithelial cell (IEC)-derived CD83 in the Treg generation in the intestine.
Yong Yu +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Antibodies targeting the activation marker CD83 can achieve immune suppression by targeting antigen-presenting mature dendritic cells (DC). This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment in mice and tested its ...
Pablo A. Silveira +15 more
doaj +1 more source
Immunological characteristics of dendritic cells marker CD83 in flounder (Paralichthys olivaceus)
Fish and Shellfish Immunology Reports, 2021 Dendritic cells (DCs) are the professional antigen presenting cells, which play important roles in regulating the immune response and tolerance. In mammals, CD83 is considered as a maturation marker for DCs, which is a type I membrane glycoprotein.
Fujing Dong +6 more
doaj +1 more source