Results 41 to 50 of about 15,671 (193)

Analysis of Nucleocytoplasmic Trafficking of the HuR Ligand APRIL and Its Influence on CD83 Expression [PDF]

, 2007
Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system and are able to sensitize even naive T cells. Mature DC are characterized by expression of CD83, a surface molecule that is proposed to be involved in efficient T cell
Heukeshoven, Jochen, Chemnitz, Jan, Joachim Hauber, Barbara Fries, Kehlenbach, Ralph H., Hauber, Ilona, Ilona Hauber, Fries, Barbara, Cordula Grüttner, Jan Chemnitz, Stocking, Carol, Carol Stocking, Gruettner, Cordula, Jochen Heukeshoven, Ralph H. Kehlenbach, Hall, Joachim   +15 more
core   +1 more source

The relation of the frequency and functional molecules expression on plasmacytoid dendritic cells to postpartum hepatitis in women with HBeAg-positive chronic hepatitis B virus infection

Frontiers in Immunology, 2022
ObjectiveTo explore the correlation between postpartum hepatitis and changes of plasmacytoid dendritic cells’ (pDC) function and frequency in hepatitis B e antigen (HBeAg)-positive pregnant women with chronic hepatitis B virus (HBV) infection ...
Fuchuan Wang, Meiying Song, Yuhong Hu, Liu Yang, Xiaoyue Bi, Yanjie Lin, Tingting Jiang, Wen Deng, Shiyu Wang, Fangfang Sun, Zhan Zeng, Yao Lu, Ge Shen, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Gang Wan, Lu Zhang, Minghui Li, Minghui Li, Yao Xie, Yao Xie   +26 more
doaj   +1 more source

Adjuvance of influenza virosomes in CTL induction in vitro [PDF]

, 2005
The induction of cytotoxic T lymphocyte (CTL) responses is of high relevance in immunological defense against intracellular pathogens and tumor cells.
Schumacher, Reto
core   +1 more source

Genetic and cross-species single-cell analyses prioritize CD83 in antigen-presenting cells as a candidate therapeutic target in asthma

Frontiers in Immunology
BackgroundAsthma remains a heterogeneous inflammatory airway disease, and current therapies, including biologics, benefit only selected patient subsets.
Guojun Qian, Qiaoyi Xu, Xuejiao Zhu, Yiying Tao, Xibing Ding, Hao Zhu, Song Zhang, Qionghui Zhan, Saihong Xu, Yan Song, Qin Hu, Hongwei Fang, Yinghui Fan, Jie Tian, Weifeng Yu   +14 more
doaj   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Anti-CD83 promotes IgG1 isotype switch in marginal zone B cells in response to TI-2 antigen

Immunobiology, 2015
CD83 is a transmembrane glycoprotein that is rapidly up-regulated on activated B cells. Although CD83 itself is incapable to transduce intracellular signaling, it acts as a negative regulator of B cell function. We have recently described that a single application of anti-CD83 antibody results in dramatically enhanced production of antigen-specific ...
Birte, Kretschmer, Jan, Weber, Andreas, Hutloff, Bernhard, Fleischer, Minka, Breloer, Anke, Osterloh   +5 more
openaire   +2 more sources

CD83 positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis leasions [PDF]

, 2003
Multiple sclerosis (MS) has a wide spectrum of clinical courses, characterized by multifocal central nervous system (CNS) damage, postulated to be mediated by CNS antigen-specific T cells.
M A Armstrong, S McQuaid, M Mirakhur, Plumb, J., Duddy, M., McQuaid, Stephen, Mirakhur, Meenakshi, J Plumb, M Duddy, Mirakhur, M., Armstrong, Marilyn, Armstrong, M. A., McQuaid, S   +12 more
core   +1 more source

Re-expression of CD14 in Response to a Combined IL-10/TLR Stimulus Defines Monocyte-Derived Cells With an Immunoregulatory Phenotype

Frontiers in Immunology, 2019
Interleukin 10 is a central regulator of the antigen-presenting function of myeloid cells. It exerts immunomodulatory effects in vivo and induces a regulatory phenotype in monocyte-derived cells in vitro.
Sören Krakow, Marie L. Crescimone, Charlotte Bartels, Verena Wiegering, Matthias Eyrich, Paul G. Schlegel, Matthias Wölfl   +6 more
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy [PDF]

, 2017
Rheumatoid arthritis (RA) is an autoimmune disease which may lead to severe disabilities due to structural joint damage and extraarticular manifestations The dendritic cell marker CD83 belongs to the immunoglobulin superfamily and has previously been ...
Stengaard-Pedersen, Kristian, Østergaard, Mikkel, Hvid, Malene, Per Höllsberg, Deleuran, Bent, Merete Lund Hetland, Höllsberg, Per, Kim Hørslev-Petersen, Kristensen, Anne-Mette, Junker, Peter, Mikkel Østergaard, Kristensen, Anne Mette Fisker, Peter Junker, Kristian Stengaard-Pedersen, Bent Deleuran, Malene Hvid, Anne-Mette Kristensen, Hetland, Merete Lund, Hørslev-Petersen, Kim   +18 more
core   +1 more source