Results 31 to 40 of about 448,583 (189)

Development of in vitro laboratory models of the tumor immune microenvironment to evaluate quality parameters and specific efficacy of the dendritic cell vaccine

Сибирский онкологический журнал, 2023
Purpose of the study: development of in vitro laboratory models to evaluate quality parameters and specific efficacy of dendritic cell vaccine (DCV).Material and Methods.
T. L. Nekhaeva, A. B. Danilova, E. I. Fedoros, N. A. Efremova, N. V. Emelyanova, M. L. Blokhina, M. N. Yurova, M. L. Tyndyk, I. A. Baldueva   +8 more
doaj   +1 more source

CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells [PDF]

International Immunology, 2007
CD83 is a member of the Ig superfamily expressed primarily by mature dendritic cells (DCs). In mice, CD83 expression by thymic stromal cells regulates CD4(+) T cell development, with CD83(-/-) mice demonstrating dramatic reductions in both thymus and peripheral CD4(+) T cells. In this study, CD83 expression was also found to affect MHC class II antigen
Yoshihiro, Kuwano, Charlene M, Prazma, Norihito, Yazawa, Rei, Watanabe, Nobuko, Ishiura, Atsushi, Kumanogoh, Hitoshi, Okochi, Kunihiko, Tamaki, Manabu, Fujimoto, Thomas F, Tedder   +9 more
openaire   +2 more sources

CD83+ dendritic cells in ulcerative and Crohn's colitis

, 2021
UVOD: Crohnova bolest (CD) i ulcerozni kolitis (UC) predstavljaju dva fenotipa upalnih bolesti crijeva (IBD). Dendritična stanica (DS), glavna antigen prezentirajuća stanica mukoze crijeva, važan je čimbenik u patogenezi IBD-a.
Rošić Despalatović, Bruna
core   +3 more sources

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83 [PDF]

, 2016
Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs thymic CD4 T cell selection. CD83 can exert cell-intrinsic and –extrinsic functions through discrete protein domains, but it remains unclear how CD83’s capacity to operate through ...
Ishido, Satoshi, Steinkasserer, Alexander, Ploegh, Hidde, Ludger Klein, Krzyzak, Lena, Petrozziello, Elisabetta, Nedjic, Jelena, Julia von Rohrscheidt, Lena Krzyzak, Christine Federle, Satoshi Ishido, Jelena Nedjic, Hidde L. Ploegh, Federle, Christine, Klein, Ludger, von Rohrscheidt, Julia, Alexander Steinkasserer, Elisabetta Petrozziello   +17 more
core   +1 more source

Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica

Veterinary Research, 2020
Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult.
María Teresa Ruiz-Campillo, Verónica Molina-Hernández, María José Bautista, Isabel L. Pacheco, Rafael Zafra, Leandro Buffoni, Francisco Javier Martínez-Moreno, Alvaro Martínez-Moreno, José Pérez   +8 more
doaj   +1 more source

Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine

Frontiers in Immunology, 2023
Advances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines.
Edgar Alonso Melgoza-González, Lorena Bustamante-Córdova, Jesús Hernández   +2 more
doaj   +1 more source

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Elisabeth Zinser, Ronald Naumann, Andreas B. Wild, Julia Michalski, Andrea Deinzer, Lena Stich, Christine Kuhnt, Alexander Steinkasserer, Ilka Knippertz   +8 more
doaj   +1 more source

Cancer cell immune mimicry delineates onco-immunologic modulation

iScience, 2021
Summary: Immune transcripts are essential for depicting onco-immunologic interactions. However, whether cancer cells mimic immune transcripts to reprogram onco-immunologic interaction remains unclear.
Rui Gao, Bin He, Qitao Huang, Zifeng Wang, Min Yan, Eric Wing-Fai Lam, Suxia Lin, Bo Wang, Quentin Liu   +8 more
doaj   +1 more source

Immunophenotyping of Sheep Paraffin-Embedded Peripheral Lymph Nodes

Frontiers in Immunology, 2018
Sheep are not only a major livestock species globally, they are also an important large animal model for biomedical research and have contributed to our understanding of the ontogeny and architecture of the mammalian immune system.
Eleonora Melzi, Mara S. Rocchi, Gary Entrican, Marco Caporale, Massimo Palmarini   +4 more
doaj   +1 more source

The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis

Frontiers in Immunology, 2022
Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, while Foxp3 was
Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier, Andreas B. Wild, Elisabeth Zinser, Petra Mühl-Zürbes, Evan Jones, Susanne Adam, Silke Frey, Maximilian Fuchs, Meik Kunz, Meik Kunz, Tobias Bäuerle, Lisa Nagel, Georg Schett, Aline Bozec, Alexander Steinkasserer   +17 more
doaj   +1 more source