Results 61 to 70 of about 5,269 (176)

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Dynamic Changes in the Phenotype of Dendritic Cells in the Uterus and Uterine Draining Lymph Nodes After Coitus

Frontiers in Immunology, 2020
Dendritic cells (DCs) are essential for successful embryo implantation. However, the properties of uterine DCs (uDCs) during the implantation period are not well characterized.
Ippei Yasuda, Ippei Yasuda, Tomoko Shima, Taiki Moriya, Ryoyo Ikebuchi, Ryoyo Ikebuchi, Yutaka Kusumoto, Akemi Ushijima, Akitoshi Nakashima, Michio Tomura, Shigeru Saito   +10 more
doaj   +1 more source

Targeting the Tumor Microenvironment Network to Overcome Immunotherapy Resistance in Non‐Small Cell Lung Cancer: Mechanisms to Clinical Translation

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Immunotherapy has transformed the treatment landscape for advanced non‐small cell lung cancer (NSCLC), yet resistance mediated by the tumor microenvironment (TME) limits its efficacy in most patients. This review aims to synthesize the current understanding of the TME as an integrated network driving immunotherapy resistance and to ...
Zengrui Wang, Zhuang Luo, Le Wang, Jiefu Tang, Zhi Zhang, Xinli Fan   +5 more
wiley   +1 more source

Construction of a 13-Gene Signature as a Novel Prognostic Marker for Patients with Clear Cell Renal Cell Carcinoma and the Role of XCR1 in Cell Proliferation

Cancer Management and Research, 2020
Baoying Yuan,1,* Feifei Li,2,* Youbao Li,3 Yuhan Chen4 1Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2The First Class Ward 2, The First Affiliated Hospital of Jinan University ...
Yuan B, Li F, Li Y, Chen Y
doaj  

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

Cell Reports, 2016
Evidence suggests that distinct splenic dendritic cell (DC) subsets activate either CD4+ or CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen presentation; however, all DC subsets can activate both T cell lineages in ...
Samuele Calabro, Dong Liu, Antonia Gallman, Manuela Sales L. Nascimento, Zizi Yu, Ting-ting Zhang, Pei Chen, Biyan Zhang, Lan Xu, Uthaman Gowthaman, Jayendra Kumar Krishnaswamy, Ann M. Haberman, Adam Williams, Stephanie C. Eisenbarth   +13 more
doaj   +1 more source

Transcutaneous immunization with a highly active form of XCL1 as a vaccine adjuvant using a hydrophilic gel patch elicits long-term CD8+ T cell responses

Journal of Pharmacological Sciences, 2020
Memory CD8+ cytotoxic T-lymphocytes (CTLs) play a key role in protective immunity against infection and cancer. However, the induction of memory CTLs with currently available vaccines remains difficult.
Momo Kamei, Kazuhiko Matsuo, Haruka Imanishi, Yuta Hara, Ying-Shu Quen, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Naoki Okada, Takashi Nakayama   +9 more
doaj   +1 more source

Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark, Marie‐Elen Tuchel, Gautier Stehli, Alessandro Genovese, Isaak Quast, Annette Oxenius   +5 more
wiley   +1 more source

Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes

Frontiers in Immunology, 2019
Vaccination strategy that induce efficient antibody responses polytopically in most lymph nodes (LNs) against infections has not been established yet.
Yusuke Kitazawa, Hisashi Ueta, Yasushi Sawanobori, Tomoya Katakai, Hiroyuki Yoneyama, Satoshi Ueha, Kouji Matsushima, Nobuko Tokuda, Kenjiro Matsuno   +8 more
doaj   +1 more source

Multi‐omics integration and machine learning identify an ACKR1+ endothelial cell‐based lactate‐immune signature associated with carotid plaque vulnerability and progression

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Ji Zhang, Qijian Zhao, Yufei Wu, Keqiang Shu, Junye Chen, Kang Li, Yuyao Feng, Xu Zhang, Wenjian Liu, Zhichao Lai, Bao Liu   +10 more
wiley   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source