Results 61 to 70 of about 672 (110)

Phenotypic and fuctional charakterization of XCR1-positive dendritic cells in the intestine

, 2015
Dendritische Zellen (DCs) nehmen fortwährend Selbst- und Fremdantigene in verschiedenen Geweben des Körpers auf, migrieren zu den drainierenden Lymphknoten und präsentieren dort Peptide dieser Antigene naiven T-Zellen, um dadurch deren Proliferation und ...
Becker, Martina
core   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Jeker, LT, Lei, Y., Jeker, L. T., Lei, Y, Georg A. Holländer, Ishimaru, N, Holländer, GA, Bösl, MR, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Malefyt, RW, Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Takahama, Y, Nagasawa, T., Nitta, T, Nagasawa, T, Izumi Ohigashi, Ripen, A. M., Hayashi, Y, Ohigashi, I., Malefyt, R. D., Takashi Nagasawa, Malefyt Rde, W., Ohigashi, I, Ripen, AM, Adiratna Mat Ripen   +36 more
core   +1 more source

RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation

Advanced Science
GWASs have identified many loci associated with osteoporosis, but the underlying genetic regulatory mechanisms and the potential drug target need to be explored.
Yan Zhang, Xin‐Hao Li, Pai Peng, Zi‐Han Qiu, Chen‐Xi Di, Xiao‐Feng Chen, Nai‐Ning Wang, Fei Chen, Yin‐Wei He, Zhong‐Bo Liu, Fan Zhao, Dong‐Li Zhu, Shan‐Shan Dong, Shou‐Ye Hu, Zhi Yang, Yi‐Ping Li, Yan Guo, Tie‐Lin Yang   +17 more
doaj   +1 more source

IL‐9 Is Essential for ILC2‐Mediated but Not Th2‐ and Th17‐Cell‐Mediated Allergic Airway Inflammation in Mice

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Autocrine IL‐9 production by ILC2s promotes their expansion and effector responses, including IL‐5‐driven eosinophilia, in response to airway allergens. In contrast, Th2 cell‐intrinsic IL‐9R signaling is dispensable for type 2 lung inflammation. Lung monocytes, macrophages, and DCs do not respond to IL‐9 in asthma models due to the absence of IL‐9R ...
Nikolaos D. Sidiropoulos, Franziska Ampenberger, Christoph Schlapbach, Christoph Schneider, Manfred Kopf   +4 more
wiley   +1 more source

XCR1 + dendritic cells promote memory CD8 + T cell recall upon secondary infections with Listeria monocytogenes or certain viruses [PDF]

, 2015
International audienceNaive CD8(+) T cell priming during tumor development or many primary infections requires cross-presentation by XCR1(+) dendritic cells (DCs).
Sonia Ghilas, Crozat, Karine, Le Bon, Agnès, Alexandre, Yannick, Sanchez, Cindy, Agnès Le Bon, Le Bon, A, Marc Dalod, Sanchez, C, Ghilas, Sonia, Ghilas, S, Crozat, K, Cindy Sanchez, Karine Crozat, Dalod, M, Yannick O. Alexandre, Dalod, Marc, Alexandre, YO   +17 more
core   +1 more source

Lung tumor development decreases the proportions of CD103⁺XCR1⁺ DC1s.

, 2021
Analysis of lung tumors and DC populations following i.v. injection of B16F10 or LLC cancer cells. (A) Lung index (lung weight/mice weight) and total lung cell number. (B) Gating strategy for the identification of total DCs.
Julyanne Brassard (4117441), David Marsolais (346229), Meredith Elizabeth Gill (11772745), Emilie Bernatchez (4117435), Véronique Desjardins (11772748), Marie-Renée Blanchet (4117438), Philippe Joubert (245361), Joanny Roy (11083635)   +7 more
core   +1 more source

Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial

MedComm, Volume 7, Issue 8, August 2026.
Radiotherapy‐induced xerostomia severely impairs quality of life. Integrated multiomics, organoids, murine models, and a randomized Phase II trial identified spermidine as a key radiation‐responsive metabolite. Oral spermidine preserved salivary gland function, maintained acinar cell integrity through Golgi‐mediated posttranslational modifications ...
Yu Min, Kun Gao, Yingtong Liu, Lei Dai, Xingchen Peng   +4 more
wiley   +1 more source

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity

Cell Reports, 2018
Summary: The ability to generate large numbers of distinct types of human dendritic cells (DCs) in vitro is critical for accelerating our understanding of DC biology and harnessing them clinically. We developed a DC differentiation method from human CD34+
Sreekumar Balan, Catharina Arnold-Schrauf, Abdenour Abbas, Norbert Couespel, Juliette Savoret, Francesco Imperatore, Alexandra-Chloé Villani, Thien-Phong Vu Manh, Nina Bhardwaj, Marc Dalod   +9 more
doaj   +1 more source

A cDC1‐NK/T‐Malignant Cell Circuit Drives Immunogenic Remodeling Under PD‐1 Blockade in Gastric Cancer

Cancer Science, Volume 117, Issue 8, Page 2098-2114, August 2026.
Chemotherapy combined with nivolumab reshapes the gastric cancer tumor microenvironment (TME) and is accompanied by an enrichment of reduced cytotoxicity NK (RC‐NK) cells. Rather than acting as classical cytotoxic effectors, these RC‐NK cells appear to shape the TME by promoting an immunostimulatory circuit that engages adaptive immunity.
Takuya Nakatsuru, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Keita H. Nagaoka, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Yuko Ishii, Sai M. Pulukuri, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source

Hematopoietic Antigen Presenting Cells Fine‐Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Our study describes how the effector maturation of intrathymic iNKT and MAIT cells is guided by distinct hematopoietic APCs: DC1s for iNKT cells and macrophages for MAIT cells. ABSTRACT The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal‐associated invariant T (MAIT) cells, in the thymus is distinct ...
Yi Wang, Trang T. Lam, Sotaro Ochiai, Abbie R. Larson, Dean B. Matthews, Hamish E.G. McWilliam, Tsuneyasu Kaisho, Mireille H. Lahoud, Jose A. Villadangos, Gretchen E. Diehl, Franca Ronchese, Daniel G. Pellicci, Mark M.W. Chong   +12 more
wiley   +1 more source