Results 61 to 70 of about 7,168 (188)

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice

Frontiers in Immunology, 2019
Targeting antigen to surface receptors on dendritic cells (DCs) can improve antibody response against subunit vaccines. We have previously observed that human XCL1-fusion vaccines target murine Xcr1+ DCs without actively inducing endocytosis of the ...
Arnar Gudjonsson, Tor Kristian Andersen, Vibeke Sundvold-Gjerstad, Bjarne Bogen, Bjarne Bogen, Even Fossum   +5 more
doaj   +1 more source

Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T‐Cell Enhancement in Immunocompetent HLA‐Transgenic Mice

Allergy, EarlyView.
Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang, Telly Sepahpour, Stephanie Kortchak, Kirthiram Krishnaveni Sivakumar, Spyros Karaiskos, Ngoc Pham, Yura Jang, Montserrat Puig, Michael Norcross   +8 more
wiley   +1 more source

Superconductivity, magnetic order, and quadrupolar order in the filled skutterudite system Pr$_{1-x}$Nd$_{x}$Os$_4$Sb$_{12}$

, 2010
Superconductivity, magnetic order, and quadrupolar order have been investigated in the filled skutterudite system Pr$_{1-x}$Nd$_{x}$Os$_4$Sb$_{12}$ as a function of composition $x$ in magnetic fields up to 9 tesla and at temperatures between 50 mK and 10
A. A. Dooraghi, C. C. Robinson, M. B. Maple, M. B. Maple, N. P. Butch, P. Fulde, P.-C. Ho, R. E. Baumbach, T. Yanagisawa, W. M. Yuhasz   +9 more
core   +1 more source

Transcriptional patterns associated with BDCA3 expression on BDCA1+ myeloid dendritic cells [PDF]

, 2018
Myeloid dendritic cells, including BDCA3hi DCs and BDCA1+ DCs (hereafter dubbed DC1 and DC2 for clarity), play a pivotal role in the induction and regulation of immune responses. Interestingly, a fraction of DC2 also express low to intermediate levels of
Aa, Aa, Bouchon, Cabec, Chen, Conway, Crozat, Crozat, Dzionek, Grajales-Reyes, Grey, Haniffa, Jaiswal, Li, Lindstedt, Lowell, Merad, Murphy, Poulin, Segura, Steinman, Subramanian, Tamura, Van De Wouwer, Williams, Worah, Yerkovich, Zhang   +27 more
core   +3 more sources

Docetaxel‐Induced Immune Activation Shows Antitumor Synergy With the Tumor‐Targeted CD40 Agonist KK2269

Cancer Science, EarlyView.
CD40 agonists have demonstrated proof‐of‐concept for converting an immunologically cold tumor into a hot tumor in preclinical studies; however, clinically, they have shown limited antitumor efficacy as monotherapy. We tested a tumor‐targeted CD40 agonist, KK2269 (a bispecific antibody that binds to CD40 and EpCAM), in combination with various ...
Yuta Tezuka, Kyoko Kawasaki, Yoshiki Sumitomo, Masato Saito, Akari Yao, Munetoshi Ando   +5 more
wiley   +1 more source

Dynamic Changes in the Phenotype of Dendritic Cells in the Uterus and Uterine Draining Lymph Nodes After Coitus

Frontiers in Immunology, 2020
Dendritic cells (DCs) are essential for successful embryo implantation. However, the properties of uterine DCs (uDCs) during the implantation period are not well characterized.
Ippei Yasuda, Ippei Yasuda, Tomoko Shima, Taiki Moriya, Ryoyo Ikebuchi, Ryoyo Ikebuchi, Yutaka Kusumoto, Akemi Ushijima, Akitoshi Nakashima, Michio Tomura, Shigeru Saito   +10 more
doaj   +1 more source

Dendritic Cell Subtypes from Lymph Nodes and Blood Show Contrasted Gene Expression Programs upon Bluetongue Virus Infection [PDF]

, 2013
Chantier qualité GAHuman and animal hemorrhagic viruses initially target dendritic cells (DCs). It has been proposed, but not documented, that both plasmacytoid DCs (pDCs) and conventional DCs (cDCs) may participate in the cytokine storm encountered in ...
Baranek T, Barratt-Boyes SM, Barratt-Boyes SM, Benjamini Y, Cisse B, Conraths FJ, Contreras V, Crozat K, De Carvalho Bittencourt M, DeMaula CD, Diana J, Diana J, Drew CP, Duan XZ, Elbers AR, Geisbert TW, Gowen BB, Guillerey C, Hensley LE, Hensley LE, Kanto T, Karsunky H, Kyle JL, MacLachlan NJ, MacLachlan NJ, Mellor AL, Moulin V, Niessen F, Pacheco R, Pascale F, Perrin A, Pichyangkul S, Sauer AV, Schwartz-Cornil I, Swiecki M, Szatmari I, Takamatsu H, Top S, Umemoto E, Umeshappa CS, Veronesi E, Wahli W, Wilson AJ, Zucchini N   +43 more
core   +4 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Construction of a 13-Gene Signature as a Novel Prognostic Marker for Patients with Clear Cell Renal Cell Carcinoma and the Role of XCR1 in Cell Proliferation

Cancer Management and Research, 2020
Baoying Yuan,1,* Feifei Li,2,* Youbao Li,3 Yuhan Chen4 1Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2The First Class Ward 2, The First Affiliated Hospital of Jinan University ...
Yuan B, Li F, Li Y, Chen Y
doaj