Results 71 to 80 of about 4,391 (150)

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, Volume 2, Issue 2, Page 55-67, June 2026.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity

Cell Reports, 2018
Summary: The ability to generate large numbers of distinct types of human dendritic cells (DCs) in vitro is critical for accelerating our understanding of DC biology and harnessing them clinically. We developed a DC differentiation method from human CD34+
Sreekumar Balan, Catharina Arnold-Schrauf, Abdenour Abbas, Norbert Couespel, Juliette Savoret, Francesco Imperatore, Alexandra-Chloé Villani, Thien-Phong Vu Manh, Nina Bhardwaj, Marc Dalod   +9 more
doaj   +1 more source

A Role of the IL‐13 Signal and Type 2 Conventional Dendritic Cell in the Atopic March

Barrier Immunity, Volume 2, Issue 2, Page 95-103, June 2026.
ABSTRACT Allergic diseases such as atopic dermatitis (AD), asthma, and food allergy originate at epithelial barrier surfaces, where environmental insults trigger immune responses. This review emphasizes the crucial role of epithelium‐derived alarmins, especially IL‐33 and TSLP, as innate danger signals (DAMPs) that establish a local type 2 milieu ...
Masato Kubo
wiley   +1 more source

Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation

European Journal of Immunology, Volume 56, Issue 6, June 2026.
• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish, Simon O'Shaughnessy, Claire Lin, Sophia Wugk, Sarah Kenny, Linda Sinclair, Suzanne Cloonan, David Finlay   +7 more
wiley   +1 more source

A DNA-Modified Live Vaccine Prime–Boost Strategy Broadens the T-Cell Response and Enhances the Antibody Response against the Porcine Reproductive and Respiratory Syndrome Virus

Viruses, 2019
The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) induces reproductive disorders in sows and respiratory illnesses in growing pigs and is considered as one of the main pathogenic agents responsible for economic losses in the porcine ...
Cindy Bernelin-Cottet, Céline Urien, Elisabeth Stubsrud, Virginie Jakob, Edwige Bouguyon, Elise Bordet, Céline Barc, Olivier Boulesteix, Vanessa Contreras, Christophe Barnier-Quer, Nicolas Collin, Ivan Trus, Hans Nauwynck, Nicolas Bertho, Isabelle Schwartz-Cornil   +14 more
doaj   +1 more source

NEOLYMPHOGENESIS AND CHEMOKINES’EXPRESSION PROFILE DURING BREAST CANCER

Креативная хирургия и онкология, 2017
The research of surgical material including a primary breast tumor, lymphatic basins with lymph nodes revealed the fact of neo-lymphatic genesis of breast cancer patients. Evidentiary basis  of the genetic  lymphoid  re-forming  is  made   with  the use 
Sh. Kh. Gantsev, A. G. Pukhov, E. K. Khusnutdinova, M. G. Galeyev, K. Sh. Gantsev, R. Sh. Ishmuratova, D. V. Islamgulov, B. Yu. Frolova, Sh. R. Kzyrgalin, Sh. I. Musin, L. V. Khalikova   +10 more
doaj   +1 more source

Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Frontiers in Immunology, 2018
Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8+ T cells, which is crucial for orchestrating efficient immune responses against viruses or tumors.
Raphaël Mattiuz, Christian Wohn, Sonia Ghilas, Marc Ambrosini, Yannick O. Alexandre, Cindy Sanchez, Anissa Fries, Thien-Phong Vu Manh, Bernard Malissen, Bernard Malissen, Marc Dalod, Karine Crozat   +11 more
doaj   +1 more source

The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity

Journal of Experimental Medicine
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Amir Ferry, Kianoosh M. Mempel, Alexander Monell, Miguel Reina-Campos, Nicole E. Scharping, Maximilian Heeg, Kennidy K. Takehara, Shiruyeh Schokrpur, Ning Kuo, Robert Saddawi-Konefka, J. Silvio Gutkind, Ananda W. Goldrath   +11 more
openaire   +3 more sources

CD8+XCR1neg Dendritic Cells Express High Levels of Toll-Like Receptor 5 and a Unique Complement of Endocytic Receptors

Frontiers in Immunology, 2019
Conventional dendritic cells (cDC) resident in the lymphoid organs of mice have been classically divided into CD8+ and CD8neg subsets. It is well-established that CD8+ dendritic cells (DCs) and their migratory counterparts in the periphery comprise the ...
Ben Wylie, James Read, Anthony C. Buzzai, Teagan Wagner, Niamh Troy, Genevieve Syn, Shane R. Stone, Bree Foley, Anthony Bosco, Mark N. Cruickshank, Jason Waithman   +10 more
doaj   +1 more source

A DNA Prime Immuno-Potentiates a Modified Live Vaccine against the Porcine Reproductive and Respiratory Syndrome Virus but Does Not Improve Heterologous Protection

Viruses, 2019
The porcine reproductive and respiratory syndrome virus (PRRSV), an RNA virus inducing abortion in sows and respiratory disease in young pigs, is a leading infectious cause of economic losses in the swine industry.
Cindy Bernelin-Cottet, Céline Urien, Maxence Fretaud, Christelle Langevin, Ivan Trus, Luc Jouneau, Fany Blanc, Jean-Jacques Leplat, Céline Barc, Olivier Boulesteix, Mickaël Riou, Marilyn Dysart, Sophie Mahé, Elisabeth Studsrub, Hans Nauwynck, Nicolas Bertho, Olivier Bourry, Isabelle Schwartz-Cornil   +17 more
doaj   +1 more source