Results 71 to 80 of about 5,269 (176)
Lung tumor development decreases the proportions of CD103+XCR1+ DC1s.
, 2021 Analysis of lung tumors and DC populations following i.v. injection of B16F10 or LLC cancer cells. (A) Lung index (lung weight/mice weight) and total lung cell number. (B) Gating strategy for the identification of total DCs.
Julyanne Brassard (4117441) +7 more
core +1 more source
The Journal of Pathology, Volume 270, Issue 2, Page 211-225, October 2026.Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 49, 3 September 2026.This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai +12 more
wiley +1 more source
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
Frontiers in Immunology, 2019 Granzyme A (GzmA), together with perforin, are well-known for their cytotoxic activity against tumor or virus-infected cells. In addition to this cytotoxic function, GzmA stimulates several immune cell types and induces inflammation in the absence of ...
Kanako Shimizu +10 more
doaj +1 more source
Advanced Science, Volume 13, Issue 50, 7 September 2026.Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao +19 more
wiley +1 more source
Advanced ScienceGWASs have identified many loci associated with osteoporosis, but the underlying genetic regulatory mechanisms and the potential drug target need to be explored.
Yan Zhang +17 more
doaj +1 more source
Advanced Science, Volume 13, Issue 52, 18 September 2026.The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui +9 more
wiley +1 more source
Chemotactic migration of cattle XCR1+ DC by mouse XCL1 and human XCL1.
, 2017 (A) The relative expression of cattle XCR1 mRNA from input cells (CD26+ DCs) in upper chamber and migrated cells (XCR1+ DC) in lower chamber. Difference in XCR1 expression between the two populations was calculated using one-tailed nonparametric t-test ...
Xueqing Ma (3687436) +13 more
core +1 more source
A novel role for lymphotactin (XCL1) signaling in the nervous system: XCL1 acts via its receptor XCR1 to increase trigeminal neuronal excitability [PDF]
, 2018 Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor ...
Bird, E.V. +13 more
core +1 more source
, 2023 Conventional type 1 dendritic cells (DC1) contribute to the development of pathogenic T helper type 1 (Th1) cells in part via the production of the proinflammatory cytokine interleukin-12.
Sherman Yu (17024937) +6 more
core +1 more source