Results 91 to 100 of about 5,269 (176)

Laser-assisted intradermal delivery of adjuvant-free vaccines targeting XCR1+ dendritic cells induces potent antitumoral responses

, 2015
The development of vaccines inducing efficient CD8(+) T cell responses is the focus of intense research. Dendritic cells (DCs) expressing the XCR1 chemokine receptor, also known as CD103(+) or CD8α(+) DCs, excel in the presentation of extracellular Ags ...
Malosse, Camille, Garbani, Mattia, Crameri, Reto, Bogen, Bjarne, Baranska, Anna, Malissen, Bernard, Fossum, Even, Henri, Sandrine, Lechat, Elmira, Terhorst, Dorothea, Tamoutounour, Samira, Braun, Reinhard, Terhorst D, Crameri R, Bogen B, Henri S, Garbani M, Fossum E, Tamoutounour S, Malosse C, Braun R, Malissen B, Baranska A, Lechat E   +23 more
core   +1 more source

A DNA-Modified Live Vaccine Prime–Boost Strategy Broadens the T-Cell Response and Enhances the Antibody Response against the Porcine Reproductive and Respiratory Syndrome Virus

Viruses, 2019
The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) induces reproductive disorders in sows and respiratory illnesses in growing pigs and is considered as one of the main pathogenic agents responsible for economic losses in the porcine ...
Cindy Bernelin-Cottet, Céline Urien, Elisabeth Stubsrud, Virginie Jakob, Edwige Bouguyon, Elise Bordet, Céline Barc, Olivier Boulesteix, Vanessa Contreras, Christophe Barnier-Quer, Nicolas Collin, Ivan Trus, Hans Nauwynck, Nicolas Bertho, Isabelle Schwartz-Cornil   +14 more
doaj   +1 more source

NEOLYMPHOGENESIS AND CHEMOKINES’EXPRESSION PROFILE DURING BREAST CANCER

Креативная хирургия и онкология, 2017
The research of surgical material including a primary breast tumor, lymphatic basins with lymph nodes revealed the fact of neo-lymphatic genesis of breast cancer patients. Evidentiary basis  of the genetic  lymphoid  re-forming  is  made   with  the use 
Sh. Kh. Gantsev, A. G. Pukhov, E. K. Khusnutdinova, M. G. Galeyev, K. Sh. Gantsev, R. Sh. Ishmuratova, D. V. Islamgulov, B. Yu. Frolova, Sh. R. Kzyrgalin, Sh. I. Musin, L. V. Khalikova   +10 more
doaj   +1 more source

The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity

Journal of Experimental Medicine
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Amir Ferry, Kianoosh M. Mempel, Alexander Monell, Miguel Reina-Campos, Nicole E. Scharping, Maximilian Heeg, Kennidy K. Takehara, Shiruyeh Schokrpur, Ning Kuo, Robert Saddawi-Konefka, J. Silvio Gutkind, Ananda W. Goldrath   +11 more
openaire   +3 more sources

A DNA Prime Immuno-Potentiates a Modified Live Vaccine against the Porcine Reproductive and Respiratory Syndrome Virus but Does Not Improve Heterologous Protection

Viruses, 2019
The porcine reproductive and respiratory syndrome virus (PRRSV), an RNA virus inducing abortion in sows and respiratory disease in young pigs, is a leading infectious cause of economic losses in the swine industry.
Cindy Bernelin-Cottet, Céline Urien, Maxence Fretaud, Christelle Langevin, Ivan Trus, Luc Jouneau, Fany Blanc, Jean-Jacques Leplat, Céline Barc, Olivier Boulesteix, Mickaël Riou, Marilyn Dysart, Sophie Mahé, Elisabeth Studsrub, Hans Nauwynck, Nicolas Bertho, Olivier Bourry, Isabelle Schwartz-Cornil   +17 more
doaj   +1 more source

Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Frontiers in Immunology, 2018
Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8+ T cells, which is crucial for orchestrating efficient immune responses against viruses or tumors.
Raphaël Mattiuz, Christian Wohn, Sonia Ghilas, Marc Ambrosini, Yannick O. Alexandre, Cindy Sanchez, Anissa Fries, Thien-Phong Vu Manh, Bernard Malissen, Bernard Malissen, Marc Dalod, Karine Crozat   +11 more
doaj   +1 more source

CD8+XCR1neg Dendritic Cells Express High Levels of Toll-Like Receptor 5 and a Unique Complement of Endocytic Receptors

Frontiers in Immunology, 2019
Conventional dendritic cells (cDC) resident in the lymphoid organs of mice have been classically divided into CD8+ and CD8neg subsets. It is well-established that CD8+ dendritic cells (DCs) and their migratory counterparts in the periphery comprise the ...
Ben Wylie, James Read, Anthony C. Buzzai, Teagan Wagner, Niamh Troy, Genevieve Syn, Shane R. Stone, Bree Foley, Anthony Bosco, Mark N. Cruickshank, Jason Waithman   +10 more
doaj   +1 more source

The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor

Virology Journal, 2008
Background Large DNA-viruses such as herpesvirus and poxvirus encode proteins that target and exploit the chemokine system of their host. The Kaposi sarcoma- associated herpes virus (KSHV) encodes three chemokines.
Lüttichau Hans R
doaj   +1 more source

Specific antigen targeting of dendritic cells via the chemokine receptor XCR1

, 2013
Dendritische Zellen (DZ) sind antigenpräsentierende Zellen, die in der Lage sind naive T Zellen zu aktivieren. Zytotoxische CD8+ T-Zellantworten werden insbesondere durch kreuzpräsentierende DZ induziert.
Hartung, Evelyn
core   +1 more source

Chemokine Receptor Profiles as Predictors of Survival and Early Progression in Follicular Lymphoma

eJHaem
Objective: Classical follicular lymphoma (FL) is a heterogeneous malignancy. Early progression within 24 months (POD24) is linked to poor outcomes. However, precise risk stratification remains unclear.
Antonella Zupo, Katrin Pansy, Lukas Gaksch, Julia Waldhart, Andrea Brunner, Johanna Strobl, Marta Szmyra‐Polomka, Sandra Haingartner, Peter V. Tomazic, Hildegard T. Greinix, Barbara Uhl, Julia Feichtinger, Georg Stary, Johannes Haybaeck, Fotini Rosi Vagena, Martin Zacharias, Christine Beham‐Schmid, Peter Neumeister, Katharina Theresa Prochazka, Alexander J. A. Deutsch   +19 more
doaj   +1 more source