Results 11 to 20 of about 176,845 (241)
Regulation of the Cell Biology of Antigen Cross-Presentation [PDF]
Annual Review of Immunology, 2018 Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I molecules with endogenous peptides during their biosynthesis within the endoplasmic reticulum. Cross-presented peptides derive from internalized proteins, microbial pathogens, and transformed or dying cells.
J Magarian Blander
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Antigen cross-presentation of immune complexes [PDF]
Frontiers in Immunology, 2014 The ability of dendritic cells (DC) to cross-present tumor antigens has long been a focus of interest of physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway
Barbara ePlatzer +2 more
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Chemotherapy enhances cross-presentation of nuclear tumor antigens. [PDF]
PLoS ONE, 2014 Cross-presentation of tumor antigen is essential for efficient priming of naïve CD8⁺ T lymphocytes and induction of effective anti-tumor immunity. We hypothesized that the subcellular location of a tumor antigen could affect the efficiency of cross ...
Chidozie C Anyaegbu +4 more
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Frontiers in Immunology, 2012 The cross-presentation of endocytosed antigen as peptide/class I MHC complexes plays a central role in the elicitation of CD8+ T cell clones that mediate anti-viral and anti-tumor immune responses.
Ewoud Bernardus Compeer +3 more
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Improved antigen cross-presentation by polyethyleneimine-based nanoparticles
International Journal of Nanomedicine, 2011 Jian Chen1, Zhengrong Li1, Hong Huang2, Yanzhu Yang2, Qian Ding2, Junhua Mai1, Wei Guo2, Yuhong Xu21School of Life Sciences and Biotechnology, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of ChinaPurpose: In the
Jian Chen +3 more
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The Role of Heat Shock Proteins in Antigen Cross Presentation [PDF]
Frontiers in Immunology, 2012 Heat shock proteins (HSP) are molecular chaperones that can bind tumor antigens (Ag) and mediate their uptake into antigen presenting cells (APC). HSP-antigen complexes are then directed towards the MHC class I pathway through antigen cross presentation ...
Ayesha eMurshid +2 more
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Antigen Presentation in the Lung
Frontiers in Immunology, 2022 The lungs are constantly exposed to environmental and infectious agents such as dust, viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped with an immune defense mechanism that involves a wide variety of immunological
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
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Molecular and cell-biological mechanisms of antigen cross-presentation [PDF]
Frontiers in Immunology, 2013 Cross-priming serves to activate cytotoxic T lymphocytes for immune defense against viruses and tumors and plays an important role in vaccinations. Only certain dendritic cell (DC) subsets can cross-present. Several cell surface markers have been described that more or less specifically and sensitively characterize these subsets.
Christian eKurts
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Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes
eLife, 2023 The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson +2 more
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Frontiers in Immunology, 2023 CD8 T cells are important antiviral effectors in the adaptive immune response to cytomegaloviruses (CMV). Naïve CD8 T cells can be primed by professional antigen-presenting cells (pAPCs) alternatively by “direct antigen presentation” or “antigen cross ...
Julia K. Büttner +8 more
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