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Antigen cross-presentation of immune complexes [PDF]
Frontiers in Immunology, 2014 The ability of dendritic cells (DC) to cross-present tumor antigens has long been a focus of interest of physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway
Barbara ePlatzer +2 more
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Live Long and Prosper for Antigen Cross-Presentation [PDF]
Immunity, 2015 Even though proteolytic antigen fragments are displayed for cross-presentation, rapid proteolysis of endocytosed antigens inhibits this process. In this issue of Immunity, Alloatti et al. (2015) describe how maturing dendritic cells keep phagosomes and lysosomes apart to ensure extended antigen life that leads to prosperous cross-presentation.
Münz, Christian +19 more
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Pathways for antigen cross presentation
Springer Seminars in Immunopathology, 2004 Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8(+) T lymphocytes after migration to the draining lymph nodes. This process, called "cross presentation" can lead either to the tolerization or activation of antigen-specific CD8(+) T cells.
Guermonprez, P, Amigorena, S
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Improved antigen cross-presentation by polyethyleneimine-based nanoparticles
International Journal of Nanomedicine, 2011 Jian Chen1, Zhengrong Li1, Hong Huang2, Yanzhu Yang2, Qian Ding2, Junhua Mai1, Wei Guo2, Yuhong Xu21School of Life Sciences and Biotechnology, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of ChinaPurpose: In the
Jian Chen +3 more
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The Role of Heat Shock Proteins in Antigen Cross Presentation [PDF]
Frontiers in Immunology, 2012 Heat shock proteins (HSP) are molecular chaperones that can bind tumor antigens (Ag) and mediate their uptake into antigen presenting cells (APC). HSP-antigen complexes are then directed towards the MHC class I pathway through antigen cross presentation ...
Ayesha eMurshid +2 more
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International Journal of Nanomedicine, 2017 Jie Gao,1–3 Lukasz J Ochyl,1,3 Ellen Yang,4 James J Moon1,3,5 1Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA; 2Department of Pharmaceutical Sciences, School of Pharmacy, Second Military Medical University ...
Gao J, Ochyl LJ, Yang E, Moon JJ
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International Journal of Nanomedicine, 2016 Chanyoung Song,* Young-Woock Noh,* Yong Taik Lim SKKU Advanced Institute of Nanotechnology (SAINT), School of Chemical Engineering, Sungkyunkwan University, Suwon, South Korea *These authors contributed equally to this work Abstract: Effective ...
Song C, Noh YW, Lim YT
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Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy
Expert Review of Clinical Immunology, 2012 Dendritic cells (DCs) possess the specialized potential to present exogenously derived antigen to cytotoxic T lymphocytes to elicit an immune response. This process, termed cross presentation, is crucial in the generation of immune response to viruses, tumors and in autoimmune disease.
Sachamitr, P, Fairchild, P
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, 2022 Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood.
Richard Simpson (9487685) +13 more
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The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation [PDF]
Frontiers in ImmunologyIntroductionModified Vaccinia Virus Ankara (MVA) is a safe vaccine vector inducing long- lasting and potent immune responses. MVA-mediated CD8+T cell responses are optimally induced, if both, direct- and cross-presentation of viral or recombinant ...
Ylenia Longo +13 more
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