Results 11 to 20 of about 6,214,641 (266)
Antigen processing and remodeling of the endosomal pathway: requirements for antigen cross-presentation. [PDF]
Frontiers in Immunology, 2012 The cross-presentation of endocytosed antigen as peptide/class I MHC complexes plays a central role in the elicitation of CD8+ T cell clones that mediate anti-viral and anti-tumor immune responses.
Ewoud Bernardus Compeer +3 more
doaj +4 more sources
Regulation of the Cell Biology of Antigen Cross-Presentation [PDF]
Annual Review of Immunology, 2018 Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I molecules with endogenous peptides during their biosynthesis within the endoplasmic reticulum. Cross-presented peptides derive from internalized proteins, microbial pathogens, and transformed or dying cells.
J Magarian Blander
exaly +5 more sources
Chemotherapy enhances cross-presentation of nuclear tumor antigens. [PDF]
PLoS ONE, 2014 Cross-presentation of tumor antigen is essential for efficient priming of naïve CD8⁺ T lymphocytes and induction of effective anti-tumor immunity. We hypothesized that the subcellular location of a tumor antigen could affect the efficiency of cross ...
Chidozie C Anyaegbu +4 more
doaj +4 more sources
Pathways for antigen cross presentation
Springer Seminars in Immunopathology, 2004 Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8(+) T lymphocytes after migration to the draining lymph nodes. This process, called "cross presentation" can lead either to the tolerization or activation of antigen-specific CD8(+) T cells.
Guermonprez, P, Amigorena, S
openaire +4 more sources
Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines [PDF]
Frontiers in Immunology, 2021 Peptide-based cancer vaccines rely upon the strong activation of the adaptive immune response to elicit its effector function. They have shown to be highly specific and safe, but have yet to prove themselves as an efficacious treatment for cancer in the ...
Alexander J. Stephens +3 more
doaj +2 more sources
Live Long and Prosper for Antigen Cross-Presentation [PDF]
Immunity, 2015 Even though proteolytic antigen fragments are displayed for cross-presentation, rapid proteolysis of endocytosed antigens inhibits this process. In this issue of Immunity, Alloatti et al. (2015) describe how maturing dendritic cells keep phagosomes and lysosomes apart to ensure extended antigen life that leads to prosperous cross-presentation.
Münz, Christian
openaire +6 more sources
Improved antigen cross-presentation by polyethyleneimine-based nanoparticles
International Journal of Nanomedicine, 2011 Jian Chen1, Zhengrong Li1, Hong Huang2, Yanzhu Yang2, Qian Ding2, Junhua Mai1, Wei Guo2, Yuhong Xu21School of Life Sciences and Biotechnology, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of ChinaPurpose: In the
Jian Chen +3 more
doaj +5 more sources
Understanding the biology of antigen cross-presentation for the design of vaccines against cancer
Frontiers in Immunology, 2014 Antigen cross-presentation, the process in which exogenous antigens are presented on MHC class I molecules, is crucial for the generation of effector CD8+ T cell responses.
Cynthia M. Fehres +3 more
doaj +3 more sources
Frontiers in Immunology, 2012 Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A. Kroczek, Volker eHenn
doaj +3 more sources
The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation [PDF]
Frontiers in ImmunologyIntroductionModified Vaccinia Virus Ankara (MVA) is a safe vaccine vector inducing long- lasting and potent immune responses. MVA-mediated CD8+T cell responses are optimally induced, if both, direct- and cross-presentation of viral or recombinant ...
Ylenia Longo +13 more
doaj +2 more sources