Results 41 to 50 of about 3,030,865 (307)

Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]

, 2009
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Manzenrieder, Florian, Elfriede Noessner, Noessner, Elfriede, Bendz, H., Buchner, J., Bendz, Henriette, Johannes Buchner, Nößner, E., Issels, Rolf D., Florian Manzenrieder, Kessler, H., Rolf D. Issels, Pandya, M.J., Manzenrieder, F., Issels, R.D., Kessler, Horst, Pandya, Maya J., Henriette Bendz, Maya J. Pandya, Buchner, Johannes, Horst Kessler   +20 more
core   +1 more source

Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation

, 2022
Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood.
Richard Simpson (9487685), M Burbage (16628115), JA Villadangos (12520366), P Kozik (16628112), MJM Bertrand (7737647), M Gros (15962255), E Segura (12520363), N Burgdorf (16628106), DC Rookhuizen (16628097), S Amigorena (16628118), M Maurin (16628109), B Baudon (16628100), S Heurtebise-Chrétien (16628103), EA Kapp (11223837)   +13 more
core   +1 more source

Antigen Presentation by Vascular Cells

Frontiers in Immunology, 2017
Antigen presentation by cells of the vessel wall may initiate rapid and localized memory immune responses in peripheral tissues. Peptide antigens displayed on major histocompatibility complex (MHC) molecules on the surface of endothelial cells (ECs) can ...
Jordan S. Pober, Jonathan Merola, Rebecca Liu, Thomas D. Manes   +3 more
doaj   +1 more source

Presentation of hepatocellular antigens [PDF]

Cellular & Molecular Immunology, 2016
The liver is an organ in which antigen-specific T-cell responses manifest a bias toward immune tolerance. This is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general.
Grakoui, Arash, Crispe, Ian Nicholas
openaire   +2 more sources

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Pieters, J., Watts, Colin, Knight, Andrew M., Colin Watts, Ferrari, Giorgio, Andrew M. Knight, Pieters, Jean, Ferrari, G., Watts, C., Jean Pieters, Giorgio Ferrari, Knight, A. M.   +11 more
core   +1 more source

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Frontiers in Immunology, 2018
Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In
Xiaolei Pei, Xiaolei Pei, Lauriel Freya Earley, Yi He, Yi He, Xiaojing Chen, Nikita Elexa Hall, Richard Jude Samulski, Richard Jude Samulski, Chengwen Li, Chengwen Li   +10 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Effect of hypochlorous acid on antigen processing and presentation [PDF]

, 2010
Dendritic cells play a key role in both innate and adaptive immunity. Recognition and presentation of antigens on the major histocompatibility complex (MHC) provide an efficient response against infections.
Prokopowicz, Z.M.
core  

Autonomous phagosomal degradation and antigen presentation in dendritic cells

, 2012
This article contains supporting information online at : www.pnas.org/lookup/suppl/doi:10.1073/pnas.1203912109/-/DCSupplementalInternational audiencePhagocytosis plays a critical role in both innate and adaptive immunity.
Fiorella Kotsias, Eik Hoffmann, Savina, Ariel, Sebastian Amigorena, Visentin, Geraldine, Kotsias, Fiorella, Bruhns, Pierre, Géraldine Visentin, Amigorena, Sebastian, Pierre Bruhns, Ariel Savina, Hoffmann, Eik   +11 more
core   +1 more source

Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation

Vaccines, 2022
The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae as the vaccine antigen, with ...
Priyal Bagwe, Lotika Bajaj, Rikhav P. Gala, Martin J. D‘Souza, Susu M. Zughaier   +4 more
doaj   +1 more source