Results 51 to 60 of about 534,463 (213)
Making Antigen Presentable [PDF]
The Journal of Immunology, 2007 In the late 1960s and early 1970s, a shift occurred in the focus of immunological research from Ab-dominated studies to ones involving cellular components of immunity such as T cells, B cells, and APCs.
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Antigen Stability Controls Antigen Presentation [PDF]
Journal of Biological Chemistry, 2004 We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Robert, Thai +6 more
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Tumor antigen cross-presentation and the dendritic cell: Where it all begins? [PDF]
, 2010 Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M. +2 more
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Studies on the role of cholesterol and coronin 1 in antigen-presenting cells [PDF]
, 2005 Antigen recognition and presentation to subsequently induce an appropriate host response is dependent on the action of antigen-presenting cells such as dendritic cells and macrophages.
Albrecht, Imke
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Antigen Presentation in the Gut
Canadian Journal of Gastroenterology, 1990 The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells.
W Doe, P Pavli
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Frontiers in Immunology, 2012 The cross-presentation of endocytosed antigen as peptide/class I MHC complexes plays a central role in the elicitation of CD8+ T cell clones that mediate anti-viral and anti-tumor immune responses.
Ewoud Bernardus Compeer +3 more
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eLife, 2021 B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells ...
Fernando Y Maeda +5 more
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The Role of FcRn in Antigen Presentation [PDF]
Frontiers in Immunology, 2014 Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to which it binds render this an important immunomodulatory molecule. In addition to the classical Fcγ
Kristi eBaker +4 more
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NLRC5, at the Heart of Antigen Presentation [PDF]
Frontiers in Immunology, 2013 Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate.
Neerincx Andreas +3 more
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Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape. [PDF]
, 1994 An immediate-early protein of murine cytomegalovirus (MCMV), pp89, elicits an immunodominant and protective major histocompatibility complex (MHC) class I Ld-restricted CD8+ T-lymphocyte response.
Stipan Jonjic +11 more
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