Results 51 to 60 of about 3,030,865 (307)

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Tumor antigen cross-presentation and the dendritic cell: Where it all begins? [PDF]

, 2010
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M., Robinson, B.W.S., Currie, A.J.   +2 more
core  

MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection

Frontiers in Immunology
Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and specificity.
Marten Meyer, Marten Meyer, Marten Meyer, Christina Parpoulas, Titouan Barthélémy, Jonas P. Becker, Jonas P. Becker, Pornpimol Charoentong, Pornpimol Charoentong, Pornpimol Charoentong, Yanhong Lyu, Selina Börsig, Selina Börsig, Nadja Bulbuc, Claudia Tessmer, Claudia Tessmer, Lisa Weinacht, David Ibberson, Patrick Schmidt, Patrick Schmidt, Rüdiger Pipkorn, Stefan B. Eichmüller, Peter Steinberger, Katharina Lindner, Katharina Lindner, Isabel Poschke, Isabel Poschke, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Michael Platten, Stefan Fröhling, Stefan Fröhling, Stefan Fröhling, Angelika B. Riemer, Angelika B. Riemer, Jessica C. Hassel, Maria Paula Roberti, Maria Paula Roberti, Dirk Jäger, Dirk Jäger, Inka Zörnig, Inka Zörnig, Frank Momburg, Frank Momburg   +46 more
doaj   +1 more source

Antigen Presentation in the Gut

Canadian Journal of Gastroenterology, 1990
The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells.
W Doe, P Pavli
doaj   +1 more source

Antigen Stability Controls Antigen Presentation [PDF]

Journal of Biological Chemistry, 2004
We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two mutations (L1A, L1A/H4Y, and H4Y). These mutations were anticipated to increase (H4Y) or decrease (L1A) the antigen non-covalent stabilizing interactions, H4Y being naturally and frequently ...
Robert, Thai, Gervaise, Moine, Michel, Desmadril, Denis, Servent, Jean-Luc, Tarride, André, Ménez, Michel, Léonetti   +6 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

eLife, 2017
The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising therapeutic target for autoimmune disorders and cancer.
Michael B Winter, Florencia La Greca, Shirin Arastu-Kapur, Francesco Caiazza, Peter Cimermancic, Tonia J Buchholz, Janet L Anderl, Matthew Ravalin, Markus F Bohn, Andrej Sali, Anthony J O'Donoghue, Charles S Craik   +11 more
doaj   +1 more source

The Role of FcRn in Antigen Presentation [PDF]

Frontiers in Immunology, 2014
Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to which it binds render this an important immunomodulatory molecule. In addition to the classical Fcγ
Kristi eBaker, Timo eRath, Timo eRath, Michal ePyzik, Richard S. Blumberg   +4 more
openaire   +5 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source