Results 31 to 40 of about 532,042 (312)

Transmembrane Helices Are an Overlooked Source of Major Histocompatibility Complex Class I Epitopes

Frontiers in Immunology, 2017
About a fourth of the human proteome is anchored by transmembrane helices (TMHs) to lipid membranes. TMHs require multiple hydrophobic residues for spanning membranes, and this shows a striking resemblance with the requirements for peptide binding to ...
Frans Bianchi, Johannes Textor, Geert van den Bogaart   +2 more
doaj   +1 more source

Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes

eLife, 2023
The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson, Theadora Ceccarelli, Malini Raghavan   +2 more
doaj   +1 more source

Antigen presentation by MHC-dressed cells

Frontiers in Immunology, 2015
Professional antigen presenting cells (APCs) such as conventional dendritic cells (DCs) process protein antigens to MHC-bound peptides and then present the peptide-MHC complexes to T cells.
Masafumi eNakayama
doaj   +1 more source

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Pieters, J., Watts, Colin, Knight, Andrew M., Colin Watts, Ferrari, Giorgio, Andrew M. Knight, Pieters, Jean, Ferrari, G., Watts, C., Jean Pieters, Giorgio Ferrari, Knight, A. M.   +11 more
core   +1 more source

Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen [PDF]

, 2021
T cells form immunological synapses with professional antigen-presenting cells (APCs) resulting in T cell activation and the acquisition of peptide antigen-MHC (pMHC) complexes from the plasma membrane of the APC. They thus become APCs themselves.
Alarcón, Balbino, Batista, Facundo, Aldo Borroto, Balbino Alarcón, Ana Villanueva, Manuel D. Diaz-Muñoz, Borroto Revuelta, Aldo, Viola L. Boccasavia, Hisse M. van Santen, Facundo D. Batista, Alonso-López, Diego, Oeste, Clara L., Cristina Prieto, Díaz-Muñoz, Manuel D., Prieto López, Cristina, Bovolenta, Elena, Bovolenta, Elena R., van Santen, Hisse, Diego Alonso-López, Alonso-López, D., Boccasavia, Viola, Santen, Hisse M. van, Batista, Facundo D., Oeste, Clara, Boccasavia, Viola L., Prieto, Cristina, Diaz-Muñoz, Manuel, Villanueva, Alberto, Elena R. Bovolenta, Clara L. Oeste, Borroto, Aldo, Villanueva, Ana   +31 more
core   +1 more source

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Frontiers in Immunology, 2018
Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In
Xiaolei Pei, Xiaolei Pei, Lauriel Freya Earley, Yi He, Yi He, Xiaojing Chen, Nikita Elexa Hall, Richard Jude Samulski, Richard Jude Samulski, Chengwen Li, Chengwen Li   +10 more
doaj   +1 more source

Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1

, 2012
peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn, Judy T Tellam, Rajiv Khanna, David J. Lynn (107188), Lea Lekieffre, Lynn, David J, Khanna, Rajiv, Judy T. Tellam (107182), Zhong, Jie, Jie Zhong (39213), Tellam, Judy T, Jie Zhong, Rajiv Khanna (107190), Lea Lekieffre (107185), Lekieffre, Lea   +14 more
core   +1 more source

Antigen Presentation by Vascular Cells

Frontiers in Immunology, 2017
Antigen presentation by cells of the vessel wall may initiate rapid and localized memory immune responses in peripheral tissues. Peptide antigens displayed on major histocompatibility complex (MHC) molecules on the surface of endothelial cells (ECs) can ...
Jordan S. Pober, Jonathan Merola, Rebecca Liu, Thomas D. Manes   +3 more
doaj   +1 more source

Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation

Vaccines, 2022
The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae as the vaccine antigen, with ...
Priyal Bagwe, Lotika Bajaj, Rikhav P. Gala, Martin J. D‘Souza, Susu M. Zughaier   +4 more
doaj   +1 more source

Presentation of hepatocellular antigens [PDF]

Cellular & Molecular Immunology, 2016
The liver is an organ in which antigen-specific T-cell responses manifest a bias toward immune tolerance. This is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general.
Grakoui, Arash, Crispe, Ian Nicholas
openaire   +2 more sources