Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes +5 more
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Tumor Antigen Presentation by Dermal Antigen-Presenting Cells [PDF]
Journal of Investigative Dermatology, 2000 Several phenotypes of antigen-presenting cells are present in the dermis, where they presumably function to present encountered antigens for immune responses. This study examined the ability of dermal antigen-presenting cells to present tumor-associated antigens for the induction of in vivo antitumor immunity.
Campton, Kristina +8 more
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Antigen presentation and T cell regulation by intestinal epithelial cells [PDF]
, 2022 Major histocompatibility complex (MHC) class II expression by intestinal epithelial cells (IECs) has been described in inflammatory bowel disease patients.
Heuberger, Cornelia
core +2 more sources
Antigen Presentation in Transplantation [PDF]
Trends in Immunology, 2016 Transplantation of solid organs between genetically distinct individuals leads, in the absence of immunosuppression, to T cell-dependent transplant rejection. Activation of graft-reactive T cells relies on the presentation of transplant-derived antigens (intact donor MHC molecules or processed peptides on host MHC molecules) by mature dendritic cells ...
Maria-Luisa, Alegre +2 more
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Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation [PDF]
, 2022 Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood.
Richard Simpson (9487685) +13 more
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Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1 [PDF]
, 2012 peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn +14 more
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The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells [PDF]
International Journal of Molecular Sciences, 2021 Professional antigen-presenting cells (APCs), such as dendritic cells and macrophages, are known for their ability to present exogenous antigens to T cells. However, many other cell types, including endothelial cells, fibroblasts, and lymph node stromal cells, are also capable of presenting exogenous antigens to either CD8+ or CD4+ T cells via cross ...
Tom J. Harryvan +3 more
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Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase [PDF]
, 1989 The regulation of antigen processing and presentation to MHC class I-restricted cytolytic T lymphocytes was studied in cells infected with murine cytomegalovirus. Recognition by cytolytic T lymphocytes of the phosphoprotein pp89, the immunodominant viral
Reddehase, Matthias J. +7 more
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Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]
, 1992 Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Koszinowski, Ulrich H. +13 more
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Chemotherapy enhances cross-presentation of nuclear tumor antigens. [PDF]
PLoS ONE, 2014 Cross-presentation of tumor antigen is essential for efficient priming of naïve CD8⁺ T lymphocytes and induction of effective anti-tumor immunity. We hypothesized that the subcellular location of a tumor antigen could affect the efficiency of cross ...
Chidozie C Anyaegbu +4 more
doaj +1 more source