Results 1 to 10 of about 30,445,468 (233)
Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K +6 more
core +23 more sources
Journal of Animal Reproduction and Biotechnology, 2022 Currently, there is no treatment to reverse or cure heart failure caused by ischemic heart disease and myocardial infarction despite the remarkable advances in modern medicine.
Yun-Gwi Park +3 more
doaj +1 more source
CAR-T cell therapy: current limitations and potential strategies
Blood Cancer Journal, 2021 Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. Although treatment with CAR-T cells has produced remarkable clinical responses with certain subsets of B cell leukemia or lymphoma, many challenges limit ...
Robert C. Sterner, Rosalie M. Sterner
semanticscholar +1 more source
Novel microRNAs modulating ecto-5′-nucleotidase expression
Frontiers in Immunology, 2023 IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape.
Theresa Kordaß +4 more
doaj +1 more source
Cell, 2022 We address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 variants. T cell responses to early variants were preserved across vaccine platforms.
A. Tarke +16 more
semanticscholar +1 more source
Long-term outcomes following CAR T cell therapy: what we know so far
Nature Reviews Clinical Oncology, 2023 Chimeric antigen receptors (CAR) are engineered fusion proteins designed to target T cells to antigens expressed on cancer cells. CAR T cells are now an established treatment for patients with relapsed and/or refractory B cell lymphomas, B cell acute ...
Kathryn M. Cappell, J. Kochenderfer
semanticscholar +1 more source
Cell, 2020 Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures.
A. Grifoni +19 more
semanticscholar +1 more source
Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data. [PDF]
, 2020 Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of haematological cancers and is currently being investigated for solid tumours, including high-grade glioma brain tumours.
Abler, Daniel +13 more
core +2 more sources
A guide to cancer immunotherapy: from T cell basic science to clinical practice
Nature reviews. Immunology, 2020 The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against cancer.
A. Waldman, Jill M. Fritz, M. Lenardo
semanticscholar +1 more source
Human T cell glycosylation and implications on immune therapy for cancer [PDF]
, 2020 Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico +3 more
core +1 more source