Results 1 to 10 of about 14,341,796 (262)
Responses of T cells to ligands for the T-cell receptor
Seminars in Immunology, 1996 We have learned a great deal about the recognition of MHC class II:peptide complexes by concentrating on the responses of a single cloned T-cell line, called D10. From these results, we argue for a single orientation of all CD4 T-cell receptors to their MHC ligands, based on the uneven top surface of MHC molecules, the repeated isolation of cells with ...
C A, Janeway, K, Bottomly
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T-Cell Activation: Two for T [PDF]
Current Biology, 1995 T-cell activation requires costimulation in addition to the antigen-specific signal. Recent results suggest that distinct costimulatory molecules can specifically activate different types of T-cell response.
Guerder, Sylvie, Flavell, Richard A.
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Nature CommunicationsAfter recognizing its ligand lipopolysaccharide, Toll-like receptor 4 (TLR4) recruits adaptor proteins to the cell membrane, thereby initiating downstream signaling and triggering inflammation.
Marvin Hering +15 more
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Frontiers in ImmunologyIntroductionNeoantigens from the Kirsten rat sarcoma viral oncogene homolog (KRAS) are specific cancer therapeutic targets. However, to date, no immune product targeting KRAS neoantigens has been approved for clinical use, and key challenges regarding ...
Zhaoduan Liang +10 more
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Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
eLife, 2014 The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein ...
Brenda Y Han +8 more
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Nature CommunicationsAlthough most patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) receiving CD19-targeted chimeric antigen receptor (CAR) T cell therapy achieve remission, loss of CAR T cell functionality and subsequent relapse remains an unmet
Lior Goldberg +27 more
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EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization
Nature Communications, 2021 The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear.
Cécile Gaston +8 more
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Frontiers in Cardiovascular Medicine, 2023 The generation of endothelial cells (ECs) from human pluripotent stem cells (PSCs) has been a promising approach for treating cardiovascular diseases for several years.
Kyung Mu Noh +3 more
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T cells in
British Journal of HaematologySummary Immune thrombocytopenia (ITP) is an autoimmune disease where premature destruction of platelets as well as inhibition of platelet production leads to thrombocytopenia and associated bleeding. It has long been considered a disease primarily caused by B cells, but the role of T lymphocytes in its pathogenesis is now better ...
Sylvain Audia, Nichola Cooper
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Regulatory T cells—the renaissance of the suppressor T cells
Annals of Medicine, 2007 Immune reactions are stringently regulated and balanced by complex interactions of stimulating and suppressing mechanisms. Dysfunctions of this sophisticated immune regulatory network can lead to a variety of diseases such as autoimmunity, allergy, cancer, and pregnancy disorders.
Tobias, Bopp +2 more
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