Results 41 to 50 of about 14,341,796 (262)

Challenging perspectives on the cellular origins of lymphoma [PDF]

Open Biology, 2016
Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon
Tim I. M. Malcolm, Daniel J. Hodson, Elizabeth A. Macintyre, Suzanne D. Turner   +3 more
doaj   +1 more source

T Cell Hybrids with T Cell Functions

, 1979
Different T cell functions, e.g. help, suppression and cytotoxicity are associated with different T cell subsets, bearing distinctive differentiation markers. Thus effector T cells mediating help are Ly 1+2−3− and may bear Ia determinants, those mediating suppression are Ly 1−2+3+, IJ+, and cytotoxic cells are Ly 1−2+3+ and do not bear Ia determinants (
Simpson, E, Kontiainen, S, Herzenberg, L, Bohrer, E, Torano, A, Vogt, P, Beverley, P, Fitzpatrick, W, Feldmann, M   +8 more
openaire   +3 more sources

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans [PDF]

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Todryk, Stephen M., Plebanski Magdalena, Bejon, P, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Urban, B, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Flanagan, KL, Hill, AV, Philip Bejon, Bejon, Philip, Marsh Kevin, Marsh, K, Mwangi, T, Mwangi, Tabitha, Flanagan, Katie, Hill, Adrian V. S., Bejon Philip, Plebanski, M, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin, Todryk, SM, Flanagan, Katie L.   +37 more
core   +1 more source

MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo

OncoImmunology
There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited.
Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya, Barbara Fazekas de St Groth   +4 more
doaj   +1 more source

Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

Nature Communications, 2019
The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti, Laurence Bataille, Jean-Marie Carpier, Stéphanie Dogniaux, Mabel San Roman-Jouve, Mathieu Maurin, Michael W. Stuck, Rosa M. Rios, Cosima T. Baldari, Gregory J. Pazour, Claire Hivroz   +10 more
doaj   +1 more source

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

Frontiers in Immunology, 2019
Recent immunotherapeutic approaches using adoptive cell therapy, or checkpoint blockade, have demonstrated the powerful anti-cancer potential of CD8 cytotoxic T-lymphocytes (CTL).
Sarah A. E. Galloway, Garry Dolton, Meriem Attaf, Aaron Wall, Anna Fuller, Cristina Rius, Valentina Bianchi, Sarah Theaker, Angharad Lloyd, Angharad Lloyd, Marine E. Caillaud, Inge Marie Svane, Marco Donia, David K. Cole, David K. Cole, Barbara Szomolay, Pierre Rizkallah, Andrew K. Sewell, Andrew K. Sewell   +18 more
doaj   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

Combination therapy with PD-1 blockade and radiofrequency ablation for recurrent hepatocellular carcinoma: a propensity score matching analysis

International Journal of Hyperthermia, 2021
Background This study aimed to evaluate whether combined therapy with PD-1 blockade (anti-PD-1) and radiofrequency ablation (RFA) is superior to RFA monotherapy for recurrent hepatocellular carcinoma (HCC).
Xiaofei Wang, Guo Liu, Shu Chen, Huaqiang Bi, Feng Xia, Kai Feng, Kuansheng Ma, Bing Ni   +7 more
doaj   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
James P. Hindley, Ann Ager, van den Berg, Hugo A., McLaren, James Edward, Ladell, Kristin Ingrid, Marsden, Morgan, Hindley, James P., Godkin, Andrew, McLaren, James E., Price, D. A., James E. McLaren, Mathew Clement, Bridgeman, Hayley, Ian R. Humphreys, David A. Price, Hindley, James Philip, Gallimore, Awen Myfanwy, Humphreys, Ian R., Linda Wooldridge, Hugo A. van den Berg, Godkin, Andrew James, Clement, Mathew, Ager, Ann, Berg, Hugo van den, Hayley M. Bridgeman, Kristin Ladell, Andrew Godkin, Awen M. Gallimore, Morgan Marsden, Ladell, Kristin, Smart, Kathryn, Price, David, Kathryn Smart, Bridgeman, Hayley M., Wooldridge, Linda, Gallimore, Awen M.   +35 more
core   +1 more source

Differential susceptibility and role for senescence in CART cells based on costimulatory domains

Molecular Cancer
Despite the success of chimeric antigen receptor T (CART) cell therapy in hematological malignancies, durable remissions remain low. Here, we report CART senescence as a potential resistance mechanism in 41BB-costimulated CART cell therapy.
Ismail Can, Elizabeth L. Siegler, Olivia L. Sirpilla, Claudia Manriquez-Roman, Kun Yun, Carli M. Stewart, Jennifer M. Feigin, Makena L. Rodriguez, Omar L. Gutierrez-Ruiz, Ekene J. Ogbodo, Truc N. Huynh, Brooke L. Kimball, Long K. Mai, Mehrdad Hefazi, Lionel Kankeu Fonkoua, Hong Xia, Imene Hamaidi, Berke Alkan, Fatih Sezer, H. Atakan Ekiz, R. Leo Sakemura, Saad S. Kenderian   +21 more
doaj   +1 more source