Results 51 to 60 of about 4,664,465 (319)
Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans [PDF]
, 2008 Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski +37 more
core +2 more sources
Differential susceptibility and role for senescence in CART cells based on costimulatory domains
Molecular CancerDespite the success of chimeric antigen receptor T (CART) cell therapy in hematological malignancies, durable remissions remain low. Here, we report CART senescence as a potential resistance mechanism in 41BB-costimulated CART cell therapy.
Ismail Can +21 more
doaj +1 more source
Frontiers in Immunology, 2019 The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells.
David Eisel +9 more
doaj +1 more source
Responses of T cells to ligands for the T-cell receptor
Seminars in Immunology, 1996 We have learned a great deal about the recognition of MHC class II:peptide complexes by concentrating on the responses of a single cloned T-cell line, called D10. From these results, we argue for a single orientation of all CD4 T-cell receptors to their MHC ligands, based on the uneven top surface of MHC molecules, the repeated isolation of cells with ...
C A, Janeway, K, Bottomly
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Mathematical modelling of T cell homeostasis [PDF]
, 2010 T cell homeostasis describes the process through which the immune system regulates cell survival, proliferation, differentiation and death to maintain T cell numbers and diversity in a range of different conditions. The aim of this thesis is to better
Bains, I.K.
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IL-4 drives exhaustion of CD8+ CART cells
Nature CommunicationsDurable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide CRISPR ...
Carli M. Stewart +20 more
doaj +1 more source
Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa
BMC Evolutionary Biology, 2017 Background The RAS signaling pathway is a pivotal developmental pathway that controls many fundamental biological processes including cell proliferation, differentiation, movement and apoptosis.
Ian J. Pepper +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks +5 more
wiley +1 more source
CD8+ memory T-cell inflation renders compromised CD4+ T-cell-dependent CD8+ T-cell immunity via naïve T-cell anergy [PDF]
, 2017 Aizhang Xu,1,2 Andrew Freywald,3 Yufeng Xie,4 Zejun Li,5 Jim Xiang1,2 1Cancer Research Cluster, Saskatchewan Cancer Agency, 2Department of Oncology, 3Department of Pathology, University of Saskatchewan, Saskatoon, SK, Canada; 4Department of Oncology ...
Freywald A, Li Z, Xie Y, Xu A, Xiang J
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