Results 21 to 30 of about 14,341,796 (262)

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]

, 1993
We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Lane, P., T Brocker, McConnell, F., S Hubele, F McConnell, Padovan, E., P Lane, E Padovan, Lanzavecchia, A., Brocker, Thomas, A Lanzavecchia, Hubele, S.   +11 more
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Immunological aspects of adult T-cell leukemia/lymphoma (ATLL), a possible neoplasm of regulatory T-cells [PDF]

, 2008
Adult T-cell leukemia/lymphoma (ATLL) is a distinct disease caused by the first discovered human oncogenic retrovirus, human T-cell leukemia virus type-1 (HTLV-1).
Yamada, Yasuaki, Kamihira, Shimeru, Yasuaki Yamada, Shimeru Kamihira   +3 more
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SPNS2 enables T cell egress from lymph nodes during an immune response

, 2021
T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability.
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Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome [PDF]

, 2021
The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role ...
Silvia Martina Tietz, Alessandro Leuti, Valerio Chiurchiu, Serhan, Charles N, Tietz, Silvia Martina, Haghayegh Jahromi, Neda, Norris, Paul C, Schouten, Marijn, de Vries, Helga E., Neda Haghayegh Jahromi, Helga de Vries, Enzmann, Gaby, Charles N Serhan, Jahromi, Neda Haghayegh, Chiurchiù, Valerio, Gaby Enzmann, Kooij, Gijs, van der Pol, Susanne M. A., Engelhardt, Britta, van der Pol, Susanne M A, Britta Engelhardt, Norris, Paul C., Serhan, Charles N., Claudio Derata Troletti, Kamermans, Alwin, Leuti, Alessandro, Paul C Norris, de Vries, Helga E, Alwin Kamermans, Derada Troletti, Claudio, Gijs Kooij, Susanne M.A. van der Pol, Marijn Schouten,   +32 more
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CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
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Chronic Inflammation Links Cancer and Parkinson’s disease

Frontiers in Aging Neuroscience, 2016
An increasing number of genetic studies suggest that the pathogenesis of Parkinson’s disease (PD) and cancer share common genes, pathways, and mechanisms.
Zhiming eLi, Zhiming eLi, Zaozao eZheng, Zaozao eZheng, Jun eRuan, Jun eRuan, Zhi eLi, Zhi eLi, Chi-Meng eTzeng, Chi-Meng eTzeng, Chi-Meng eTzeng   +10 more
doaj   +1 more source

Downregulation of HMGB1 in thymoma cells affects T cell differentiation

Central European Journal of Immunology, 2023
Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma
Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang   +5 more
doaj   +1 more source

T–cell anergy and peripheral T–cell tolerance [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
The discovery that T–cell recognition of antigen can have distinct outcomes has advanced understanding of peripheral T–cell tolerance, and opened up new possibilities in immunotherapy. Anergy is one such outcome, and results from partial T–cell activation.
R, Lechler, J G, Chai, F, Marelli-Berg, G, Lombardi   +3 more
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.

, 2023
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME).
Fortin, J., Tobin, C., Mason, C.E., Leca, J., Butler, Daniel, de Leval, Laurence, Fortin, Jerome, Tobin, Chantal, Melnick, Ari, Sakamoto, Takashi, Foox, J., Gaulard, P., El Ghamrasni, Samah, Mak, Tak W., Lemonnier, F., Smith, Logan K., Sakamoto, T., Berger, T., Haight, J., Gaulard, Philippe, Mak, T.W., Mboumba, D.L., Duncan, Gordon S., Melnick, A., Butler, D., Lemonnier, Franҫois, Mason, Christopher E., Hodgson, K., Berger, Thorsten, Leca, Julie, Hodgson, Kelsey, Haight, Jillian, Meydan, C., Smith, L.K., Foox, Jonathan, Mboumba, Diana Laure, Meydan, Cem, Elia, Andrew J., El Ghamrasni, S., Duncan, G.S., Elia, A.J., de Leval, L.   +41 more
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The T‐cell receptor repertoire of regulatory T cells [PDF]

Immunology, 2008
SummaryThe CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases.
Rafal, Pacholczyk, Joanna, Kern
openaire   +2 more sources