Results 11 to 20 of about 4,664,465 (319)

Novel microRNAs modulating ecto-5′-nucleotidase expression

Frontiers in Immunology, 2023
IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape.
Theresa Kordaß, Theresa Kordaß, Tsu-Yang Chao, Wolfram Osen, Stefan B. Eichmüller   +4 more
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment. [PDF]

, 2023
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME).
Fortin, J., Tobin, C., Mason, C.E., Leca, J., Butler, Daniel, de Leval, Laurence, Fortin, Jerome, Tobin, Chantal, Melnick, Ari, Sakamoto, Takashi, Foox, J., Gaulard, P., El Ghamrasni, Samah, Mak, Tak W., Lemonnier, F., Smith, Logan K., Sakamoto, T., Berger, T., Haight, J., Gaulard, Philippe, Mak, T.W., Mboumba, D.L., Duncan, Gordon S., Melnick, A., Butler, D., Lemonnier, Franҫois, Mason, Christopher E., Hodgson, K., Berger, Thorsten, Leca, Julie, Hodgson, Kelsey, Haight, Jillian, Meydan, C., Smith, L.K., Foox, Jonathan, Mboumba, Diana Laure, Meydan, Cem, Elia, Andrew J., El Ghamrasni, S., Duncan, G.S., Elia, A.J., de Leval, L.   +41 more
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Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC

Scientific Reports, 2022
The differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes.
Hideyuki Hiyoshi, Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Shinya Asano, Taisuke Mochida, Junji Yamaura, Shuhei Konagaya, Ryo Fujii, Hirokazu Matsumoto, Ryo Ito, Taro Toyoda   +10 more
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PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells [PDF]

, 2020
Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies.
Kuster, B., Chennupati, V, Tiganis, T, Cullen, J.G., Flosbach, M, von Hoesslin, M., Oberle, SG, von Hoesslin, M, List, M, List, M., Zecha, J, Pauling, JK, Zecha, J., Tiganis, T., Chennupati, V., Wiede, F, Baumbach, J., Baumbach, J, Pauling, J.K., Zehn, D, Scherer, S., Wiede, F., Oberle, S.G., Kuster, B, Scherer, S, Flosbach, M., Zehn, D., Cullen, JG   +27 more
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SPNS2 enables T cell egress from lymph nodes during an immune response [PDF]

, 2021
T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability.
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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis [PDF]

, 2020
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive.
Jiang, Jue, Han, Meng, Wang, Yanwu, Zhang, Yingchi, Feng, Hui, Zhu, Xiaofan, Qing, Guoliang, Sun, Yonghua, Wu, Chao, Yue, Ming, Cai, Xiaolian, Jiang, Peng, Wang, Tianci, Li, Peng, Liu, Hudan, Su, Hexiu, Wang, Jingchao, Xiao, Wuhan   +17 more
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Recent advances in edible coating of food products and its legislations: A review

Journal of Agriculture and Food Research, 2023
Food products are highly perishable in nature which undergoes quick quality deterioration. In this note, the kind of packaging decides the active preservation of food qualities.
Krishna Priya, Nirmal Thirunavookarasu, D.V. Chidanand   +2 more
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ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

Nature Communications, 2021
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of ...
Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida   +20 more
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A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

Nature Communications, 2021
T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor ...
Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Suguru Arima, Mihoko Kunitomo, Takayuki Sato, Tatsuki Ueda, Atsutaka Minagawa, Yuta Mishima, Nariaki Yanagawa, Yuji Baba, Yasuyuki Miyake, Kazuhide Nakayama, Maiko Takiguchi, Tokuyuki Shinohara, Tetsuya Nakatsura, Masaki Yasukawa, Yoshiaki Kassai, Akira Hayashi, Shin Kaneko   +19 more
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The impact of ageing on the human haematopoietic stem cell and memory T cell compartments through the lens of single cell transcriptome analysis [PDF]

, 2022
Human biological ageing comprises the molecular and physiological changes that negatively affect homeostasis with age and are strongly associated with susceptibility to disease and ultimately death.
Gafencu, Grigore-Aristide
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