Results 11 to 20 of about 4,652,143 (319)

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells [PDF]

, 2020
Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies.
Kuster, B., Chennupati, V, Tiganis, T, Cullen, J.G., Flosbach, M, von Hoesslin, M., Oberle, SG, von Hoesslin, M, List, M, List, M., Zecha, J, Pauling, JK, Zecha, J., Tiganis, T., Chennupati, V., Wiede, F, Baumbach, J., Baumbach, J, Pauling, J.K., Zehn, D, Scherer, S., Wiede, F., Oberle, S.G., Kuster, B, Scherer, S, Flosbach, M., Zehn, D., Cullen, JG   +27 more
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Immunological aspects of adult T-cell leukemia/lymphoma (ATLL), a possible neoplasm of regulatory T-cells [PDF]

, 2008
Adult T-cell leukemia/lymphoma (ATLL) is a distinct disease caused by the first discovered human oncogenic retrovirus, human T-cell leukemia virus type-1 (HTLV-1).
Yamada, Yasuaki, Kamihira, Shimeru, Yasuaki Yamada, Shimeru Kamihira   +3 more
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CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
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T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

Cell Reports, 2020
Summary: T cell factor 1 (Tcf1) promotes the central memory CD8+ T (TCM) cell differentiation and stemness in lymphoid tissues after systemic infections.
Jingxia Wu, Alaa Madi, Alessa Mieg, Agnes Hotz-Wagenblatt, Nina Weisshaar, Sicong Ma, Kerstin Mohr, Tilo Schlimbach, Marvin Hering, Helena Borgers, Guoliang Cui   +10 more
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Ex-vivo CS1-OKT3 dual specific bivalent antibody-armed effector T cells mediate cellular immunity against multiple myeloma

Scientific Reports, 2023
Bispecific T cell engaging antibodies (bsAbs) have emerged as novel and powerful therapeutic agents for redirecting T cells towards antigen-specific tumor killing.
Dennis Awuah, Lin Li, Lindsay Williams, Ryan Urak, Maciej Kujawski, Stephen J. Forman, John E. Shively, Xiuli Wang   +7 more
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Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome [PDF]

, 2021
The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role ...
Silvia Martina Tietz, Alessandro Leuti, Valerio Chiurchiu, Serhan, Charles N, Tietz, Silvia Martina, Haghayegh Jahromi, Neda, Norris, Paul C, Schouten, Marijn, de Vries, Helga E., Neda Haghayegh Jahromi, Helga de Vries, Enzmann, Gaby, Charles N Serhan, Jahromi, Neda Haghayegh, Chiurchiù, Valerio, Gaby Enzmann, Kooij, Gijs, van der Pol, Susanne M. A., Engelhardt, Britta, van der Pol, Susanne M A, Britta Engelhardt, Norris, Paul C., Serhan, Charles N., Claudio Derata Troletti, Kamermans, Alwin, Leuti, Alessandro, Paul C Norris, de Vries, Helga E, Alwin Kamermans, Derada Troletti, Claudio, Gijs Kooij, Susanne M.A. van der Pol, Marijn Schouten,   +32 more
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A novel CCM2 gene mutation associated with family cerebral cavernous malformation

Frontiers in Aging Neuroscience, 2016
Background: Cerebral cavernous malformations (CCMs) are common vascular malformations that predominantly arise in the central nervous system and are mainly characterized by enlarged vascular cavities without intervening brain parenchyma.
Wen-Qing Huang, Wen-Qing Huang, Cong-Xia Lu, Ya Zhang, Ya Zhang, Ke-Hui Yi, Liang-Liang Cai, Liang-Liang Cai, Ming-Li Li, Ming-Li Li, Han Wang, Han Wang, Qing Lin, Qing Lin, Chi-Meng Tzeng, Chi-Meng Tzeng, Chi-Meng Tzeng   +16 more
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EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

Nature Communications, 2021
The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear.
Cécile Gaston, Simon De Beco, Bryant Doss, Meng Pan, Estelle Gauquelin, Joseph D’Alessandro, Chwee Teck Lim, Benoit Ladoux, Delphine Delacour   +8 more
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Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]

, 2008
The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg, Habu, S., Holländer, G. A., Hozumi, K., Hirano, K, Mailhos, C, Ken-ichi Hirano, Negishi, N, Saulius Zuklys, Habu, S, Zuklys, S, Yahata, T., Sonoko Habu, Mailhos, C., Georg A. Holländer, Naoko Negishi, Ando, K., Ando, K, Kiyoshi Ando, Holländer, GA, Shima, D. T., Negishi, N., Carolina Mailhos, Hozumi, K, Yahata, T, Shima, DT, Hirano, K., Katsuto Hozumi, Takashi Yahata, David T. Shima, Zuklys, S.   +30 more
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.

, 2023
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell lymphoma that originates from T follicular helper (Tfh) cells and exhibits a prominent tumor microenvironment (TME).
Fortin, J., Tobin, C., Mason, C.E., Leca, J., Butler, Daniel, de Leval, Laurence, Fortin, Jerome, Tobin, Chantal, Melnick, Ari, Sakamoto, Takashi, Foox, J., Gaulard, P., El Ghamrasni, Samah, Mak, Tak W., Lemonnier, F., Smith, Logan K., Sakamoto, T., Berger, T., Haight, J., Gaulard, Philippe, Mak, T.W., Mboumba, D.L., Duncan, Gordon S., Melnick, A., Butler, D., Lemonnier, Franҫois, Mason, Christopher E., Hodgson, K., Berger, Thorsten, Leca, Julie, Hodgson, Kelsey, Haight, Jillian, Meydan, C., Smith, L.K., Foox, Jonathan, Mboumba, Diana Laure, Meydan, Cem, Elia, Andrew J., El Ghamrasni, S., Duncan, G.S., Elia, A.J., de Leval, L.   +41 more
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