Results 11 to 20 of about 30,445,587 (352)

Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC

open access: yesScientific Reports, 2022
The differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes.
Hideyuki Hiyoshi   +10 more
doaj   +1 more source

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. [PDF]

open access: yes, 2017
T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Coles, Marc   +10 more
core   +6 more sources

Recent advances in edible coating of food products and its legislations: A review

open access: yesJournal of Agriculture and Food Research, 2023
Food products are highly perishable in nature which undergoes quick quality deterioration. In this note, the kind of packaging decides the active preservation of food qualities.
Krishna Priya   +2 more
doaj   +1 more source

Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses.

open access: yesCell, 2021
CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We found enrichment of TFH cell transcriptional signature correlates with GC B
Can Cui   +15 more
semanticscholar   +1 more source

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

open access: yesNature Communications, 2021
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of ...
Kenji Miki   +20 more
doaj   +1 more source

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

open access: yesNature Communications, 2021
T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor ...
Shoichi Iriguchi   +19 more
doaj   +1 more source

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

open access: yes, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua   +4 more
core   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

open access: yes, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller   +41 more
core   +1 more source

Chronic Inflammation Links Cancer and Parkinson’s disease

open access: yesFrontiers in Aging Neuroscience, 2016
An increasing number of genetic studies suggest that the pathogenesis of Parkinson’s disease (PD) and cancer share common genes, pathways, and mechanisms.
Zhiming eLi   +10 more
doaj   +1 more source

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

open access: yesbioRxiv, 2020
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in a large cohort of unexposed ...
T. Sekine   +28 more
semanticscholar   +1 more source

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