Results 11 to 20 of about 14,341,796 (262)

In vitro maturation of human pluripotent stem cell-derived cardiomyocyte: A promising approach for cell therapy

Journal of Animal Reproduction and Biotechnology, 2022
Currently, there is no treatment to reverse or cure heart failure caused by ischemic heart disease and myocardial infarction despite the remarkable advances in modern medicine.
Yun-Gwi Park, Yeo-Jin Son, Sung-Hwan Moon, Soon-Jung Park   +3 more
doaj   +1 more source

Novel microRNAs modulating ecto-5′-nucleotidase expression

Frontiers in Immunology, 2023
IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape.
Theresa Kordaß, Theresa Kordaß, Tsu-Yang Chao, Wolfram Osen, Stefan B. Eichmüller   +4 more
doaj   +1 more source

Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC

Scientific Reports, 2022
The differentiation of pancreatic endocrine cells from human pluripotent stem cells has been thoroughly investigated for their application in cell therapy against diabetes.
Hideyuki Hiyoshi, Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Shinya Asano, Taisuke Mochida, Junji Yamaura, Shuhei Konagaya, Ryo Fujii, Hirokazu Matsumoto, Ryo Ito, Taro Toyoda   +10 more
doaj   +1 more source

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells [PDF]

, 2020
Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies.
Kuster, B., Chennupati, V, Tiganis, T, Cullen, J.G., Flosbach, M, von Hoesslin, M., Oberle, SG, von Hoesslin, M, List, M, List, M., Zecha, J, Pauling, JK, Zecha, J., Tiganis, T., Chennupati, V., Wiede, F, Baumbach, J., Baumbach, J, Pauling, J.K., Zehn, D, Scherer, S., Wiede, F., Oberle, S.G., Kuster, B, Scherer, S, Flosbach, M., Zehn, D., Cullen, JG   +27 more
core   +1 more source

Donor T cells for CAR T cell therapy

Biomarker Research, 2022
AbstractAdoptive cell therapy using patient-derived chimeric receptor antigen (CAR) T cells redirected against tumor cells has shown remarkable success in treating hematologic cancers. However, wider accessibility of cellular therapies for all patients is needed.
Tang, TCY, Xu, N, Nordon, R, Haber, M, Micklethwaite, K, Dolnikov, A   +5 more
openaire   +4 more sources

The impact of ageing on the human haematopoietic stem cell and memory T cell compartments through the lens of single cell transcriptome analysis [PDF]

, 2022
Human biological ageing comprises the molecular and physiological changes that negatively affect homeostasis with age and are strongly associated with susceptibility to disease and ultimately death.
Gafencu, Grigore-Aristide
core   +1 more source

Recent advances in edible coating of food products and its legislations: A review

Journal of Agriculture and Food Research, 2023
Food products are highly perishable in nature which undergoes quick quality deterioration. In this note, the kind of packaging decides the active preservation of food qualities.
Krishna Priya, Nirmal Thirunavookarasu, D.V. Chidanand   +2 more
doaj   +1 more source

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

Nature Communications, 2021
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of ...
Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida   +20 more
doaj   +1 more source

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

Nature Communications, 2021
T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor ...
Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Suguru Arima, Mihoko Kunitomo, Takayuki Sato, Tatsuki Ueda, Atsutaka Minagawa, Yuta Mishima, Nariaki Yanagawa, Yuji Baba, Yasuyuki Miyake, Kazuhide Nakayama, Maiko Takiguchi, Tokuyuki Shinohara, Tetsuya Nakatsura, Masaki Yasukawa, Yoshiaki Kassai, Akira Hayashi, Shin Kaneko   +19 more
doaj   +1 more source

T-cell memory: the importance of chemokine-mediated cell attraction [PDF]

, 2006
A recent study demonstrates the involvement of certain chemokines in immune response initiation and CD8+ T-cell memory formation.
Moser, Bernhard, Bernhard Moser
core   +1 more source