Results 11 to 20 of about 6,692 (213)
Forward vaccinology: CTL targeting based upon physical detection of HLA-bound peptides
Frontiers in Immunology, 2014 Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers.
Ellis L Reinherz +2 more
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The Binding Effect of the Constitutive Documents of Companies: The 1973 and 2008 Companies Acts of South Africa [PDF]
Potchefstroom Electronic Law Journal, 2010 This contribution examines the provisions of the constitutive documents of companies under two specific provisions, namely s 65(2) of the Companies Act 61 of 1973 and s 15(6) of the Companies Act 71 of 2008.
TCR Morajane
doaj
Biophysical aspects of T lymphocyte activation at the immune synapse
Frontiers in Immunology, 2016 T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen ...
Claire eHivroz
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TCR‐engineered T cells: A model of inducible TCR expression to dissect the interrelationship between two TCRs [PDF]
European Journal of Immunology, 2013 TCR gene modified T cells for adoptive therapy simultaneously express the Tg TCR and the endogenous TCR, which might lead to mispaired TCRs with harmful unknown specificity and to a reduced function of TCR‐Tg T cells. We generated dual TCR T cells in two settings in which either TCR was constitutively expressed by a retroviral promoter while the second
Reuß, S. +6 more
openaire +3 more sources
Frontiers in Immunology, 2016 The ability of CD4+ T cells to differentiate into effector subsets underpins their ability to shape the immune response and mediate host protection.
Nicholas eVan Panhuys
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Revisiting the discovery of the αβ TCR complex and its co-receptors
Frontiers in Immunology, 2014 (not required)
Ellis L Reinherz
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TCR–pMHC bond conformation controls TCR ligand discrimination [PDF]
Cellular & Molecular Immunology, 2019 Abstract A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζ receptors at the membranes of live primary T ...
Dibyendu K. Sasmal +12 more
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Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop [PDF]
Nature Communications, 2013 Self-reactive CD4 T cells are thought to have a central role in the pathogenesis of many chronic inflammatory human diseases. Microbial peptides can activate self-reactive T cells, but the structural basis for such crossreactivity is not well understood.
Dhruv K, Sethi +3 more
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OncoImmunology, 2019 Ovarian cancer (OC) has an overall modest number of mutations that facilitate a functional immune infiltrate able to recognize tumor mutated antigens, or neoantigens.
Muzamil Yaqub Want +9 more
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Adoptivna celična terapija in limfociti T z izraženimi himernimi antigenskimi receptorji
Zdravniški Vestnik, 2020 Pri zdravljenju raka se trenutno uporabljajo pristopi kirurškega zdravljenja, radio- in kemoterapije ter različne kombinacije teh pristopov. Kot 'četrti steber' onkološkega zdravljenja se razvija imunoterapija.
Uroš Rajčević
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