Results 11 to 20 of about 156,157 (263)
On the Control of TCR Phosphorylation [PDF]
Frontiers in Immunology, 2012 The T-cell receptor (TCR) is responsible first of all for recognizing small peptides embedded in major histocompatibility complex molecules (pMHC). The information that a complex has thus formed is then transduced across the membrane via “triggering” of the TCR.
Fernandes, R +4 more
openaire +3 more sources
TCR Antagonism by Peptide Requires High TCR Expression [PDF]
The Journal of Immunology, 2008 Abstract Current models of T cell activation focus on the kinetics of TCR-ligand interactions as the central parameter governing T cell responsiveness. However, these kinetic parameters do not adequately predict all T cell behavior, particularly the response to antagonist ligands.
Daniel S, Jones +4 more
openaire +2 more sources
The Safety on the TCR Trigger [PDF]
Cell, 2008 In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.
Kuhns, Michael S., Davis, Mark M.
openaire +2 more sources
Competitive Displacement of pTα by TCR-α During TCR Assembly Prevents Surface Coexpression of Pre-TCR and αβ TCR [PDF]
The Journal of Immunology, 2000 Abstract During αβ T cell development, CD4−CD8− thymocytes first express pre-TCR (pTα/TCR-β) before their differentiation to the CD4+CD8+ stage. Positive selection of self-tolerant T cells is then determined by the αβ TCR expressed on CD4+CD8+ thymocytes.
Sébastien Trop +4 more
openaire +1 more source
TCR‐engineered T cells: A model of inducible TCR expression to dissect the interrelationship between two TCRs [PDF]
European Journal of Immunology, 2013 TCR gene modified T cells for adoptive therapy simultaneously express the Tg TCR and the endogenous TCR, which might lead to mispaired TCRs with harmful unknown specificity and to a reduced function of TCR‐Tg T cells. We generated dual TCR T cells in two settings in which either TCR was constitutively expressed by a retroviral promoter while the second
Reuß, S. +6 more
openaire +3 more sources
An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach [PDF]
Advanced scienceAn injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Huang Y +15 more
europepmc +2 more sources
Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop [PDF]
Nature Communications, 2013 Self-reactive CD4 T cells are thought to have a central role in the pathogenesis of many chronic inflammatory human diseases. Microbial peptides can activate self-reactive T cells, but the structural basis for such crossreactivity is not well understood.
Dhruv K, Sethi +3 more
openaire +2 more sources
Revisiting the discovery of the αβ TCR complex and its co-receptors
Frontiers in Immunology, 2014 (not required)
Ellis L Reinherz
doaj +1 more source
TCR–pMHC bond conformation controls TCR ligand discrimination [PDF]
Cellular & Molecular Immunology, 2019 Abstract A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζ receptors at the membranes of live primary T ...
Dibyendu K. Sasmal +12 more
openaire +2 more sources
OncoImmunology, 2019 Ovarian cancer (OC) has an overall modest number of mutations that facilitate a functional immune infiltrate able to recognize tumor mutated antigens, or neoantigens.
Muzamil Yaqub Want +9 more
doaj +1 more source