Results 51 to 60 of about 156,157 (263)

Strict major histocompatibility complex (MHC) molecule class-specific binding by co-receptors enforces MHC-restricted αβTCR recognition during T lineage subset commitment

Frontiers in Immunology, 2013
Since the discovery of co-receptor dependent αβTCR recognition, considerable effort has been spent on elucidating the basis of CD4 and CD8 lineage commitment in the thymus.
Xiao-long eLi, Xiao-long eLi, Mai-kun eTeng, Ellis L Reinherz, Jia-huai eWang, Jia-huai eWang, Jia-huai eWang   +6 more
doaj   +1 more source

Signalling initiated with CD4–TCR or TCR–TCR interactions: comparison of tyrosine phosphorylation patterns and CD45 effects

Immunology Letters, 1998
Antigen-triggered response in T cells is mediated by the T cell receptor (TCR)/CD3-complex. This signalling, however, is modulated by a number of other surface molecules. Among the most important of these is the CD4/CD8 molecule which associates with the TCR/CD3-complex and binds to the MHC complex.
A, Ståhls, S C, Hong, G E, Liwszyc, C, Janeway, L C, Andersson, H, Wolff   +5 more
openaire   +2 more sources

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Circulating α4β7+ Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire

Clinical and Experimental Gastroenterology, 2020
Adir Gamliel,1,2 Lael Werner,1,2 Marina Pinsker,1,3 Naomi Salamon,1 Batia Weiss,1,2 Dror S Shouval1,2 1Pediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, Israel; 2Sackler Faculty of Medicine,
Gamliel A, Werner L, Pinsker M, Salamon N, Weiss B, Shouval DS   +5 more
doaj  

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response

OncoImmunology, 2018
The role of T cell receptor (TCR) signaling for adaptive immune responses is essential. The ability to respond to a broad spectrum of tumor antigens requires an adaptive selection of various TCR. So far, little is known about the role of TCR richness and
Benjamin A. Kansy, Gulidanna Shayan, Hyun-Bae Jie, Sandra P. Gibson, Yu L. Lei, Sven Brandau, Stephan Lang, Nicole C Schmitt, Fei Ding, Yan Lin, Robert L. Ferris   +10 more
doaj   +1 more source

Dynamic perturbations of the T-cell receptor repertoire in chronic HIV infection and following antiretroviral therapy.

Frontiers in Immunology, 2016
HIV infection profoundly affects many parameters of the immune system and ultimately leads to AIDS, yet which factors are most important for determining resistance, pathology and response to antiretroviral treatment – and how best to monitor them ...
James Malcolm Heather, Katharine eBest, Theres eOakes, Eleanor R Gray, Jennifer eRoe, Niclas eThomas, Nir eFriedman, Mahdad eNoursadeghi, Benny eChain   +8 more
doaj   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Longitudinal tracking of T-cell repertoire reveals long-lasting CD4⁺ yellow fever specific clone cluster

Инфекция и иммунитет
Infection is inconceivable without T cells. T cells not only eliminate virus-infected cells and participate in the formation of immunological memory, but also indirectly modulate the humoral response through the selection and maintenance of specific B ...
Mariia A. Salnikova, Yu. B. Lebedev
doaj   +1 more source