Results 61 to 70 of about 156,157 (263)
A method for missing the effect of mutual concluding radio signal in onboard equipment of the telemetry, command and ranging system [PDF]
Космические аппараты и технологииA specific feature of the telemetry, command and ranging system is the need to receive spacecraft control commands from the ground station at any given position.
D. V. Sbitnev, M. G. Polyak
doaj +1 more source
Advanced Science, EarlyView.TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
OncoImmunology, 2020 Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Current systemic therapies result only in modest benefits and new therapeutic options are critically needed.
Peter G. Hendrickson +6 more
doaj +1 more source
Orientation‐Engineered Insulator‐Metal Transition in Vanadium Dioxide
Advanced Science, EarlyView.Crystallographic orientation engineering in VO2/TiO2 heterostructures enables tunable insulator‐metal transitions. The high‐Miller‐index (102) orientation breaks in‐plane mirror symmetry, inducing anisotropic transport, while its inclined oxygen channels accelerate protonation kinetics.
Xuanchi Zhou +4 more
wiley +1 more source
Frontiers in Immunology, 2011 T cell receptor (TCR) recognition is intrinsically polyspecific. In the field of autoimmunity, recognition of both self- and microbial peptides by a single TCR has led to the concept of molecular mimicry.
Roland S. LIBLAU
doaj +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
An old twist in HLA-A: CDR3 alpha hook up at an R65-joint
Frontiers in Immunology, 2015 T-cell ontogeny optimizes the alpha/beta T-cell receptor (TCR) repertoire for recognition of major histocompatibility complex (MHC) class-I/-II genetic polymorphism; and co-evolution of TCR germline V-gene segments and the MHC must entail somatic ...
Joseph eMurray
doaj +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
Structure-based, rational design of T cell receptors
Frontiers in Immunology, 2013 Adoptive cell transfer using engineered T cells is emerging as a promising treatment for metastatic melanoma. Such an approach allows one to introduce TCR modifications that, while maintaining the specificity for the targeted antigen, can enhance the ...
Vincent eZoete +7 more
doaj +1 more source
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source