Results 81 to 90 of about 6,692 (213)
Journal of Hepatocellular Carcinoma, 2021 Jiamin Cheng,1,* Yinyin Li,1,* Xiaohui Wang,2,* Zheng Dong,1 Yan Chen,1 Rui Zhang,1 Jiagan Huang,1 Xueyuan Jin,1 Jianfei Yao,2 Aifang Ge,2 Lele Song,2,3,* Yinying Lu,1 Zhen Zeng1 1Comprehensive Liver Cancer Department, The Fifth Medical ...
Cheng J +12 more
doaj
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
pH‐Driven Actuation of Unmodified DNA Origami Rectangles
Angewandte Chemie, EarlyView.Unmodified DNA origami rectangles exhibit a reversible transition between planar and tubular states driven by near‐neutral pH changes. This behavior arises from crossover‐mediated mechanical coupling of overwound DNA and extends to dimers and nanoribbons, enabling the formation of nanotube architectures without added motifs or chemical modification ...
Diego A. Uehara +4 more
wiley +2 more sources
The Testosterone: Cortisol Ratio - A Tool with Practical Use and Research Potential in Endocrinology
Indian Journal of Endocrinology and MetabolismTestosterone is a predominantly anabolic hormone whereas cortisol is a catabolic hormone. Measurement of testosterone-cortisol ratio (TCR) can serve as a surrogate for the balance in the anabolic: catabolic states in the body and was studied as a marker ...
Sunetra Mondal +3 more
doaj +1 more source
The mutational status of p53 can influence its recognition by human T-cells
OncoImmunology, 2017 p53 was reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in its inactivation and often accumulation in tumor cells.
Katerina Shamalov +3 more
doaj +1 more source
From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits
Advanced Science, EarlyView.This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang +5 more
wiley +1 more source
Thin‐Film Thermal Sensors on Chitosan Substrates for Sustainable Transient Electronics
Advanced Electronic Materials, EarlyView.Fully transient thin‐film temperature sensors are realized on pure chitosan substrates using Mo‐based RTDs and a‐IGZO/Mo thermistors. The devices exhibit high sensitivity, mechanical flexibility, humidity‐aware operation, and complete dissolution in natural solvents.
Ahmed Rasheed +14 more
wiley +1 more source