Results 21 to 30 of about 15,994,939 (300)
T cell antigen discovery via Signaling and Antigen presenting Bifunctional Receptors
Nature Methods, 2019 CD8+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite progress in characterizing the antitumor T cell repertoire and function, the identification of target antigens remains a challenge.
Alok V. Joglekar +11 more
semanticscholar +1 more source
The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]
, 1992 Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Wegener, Anne-Marie K. +19 more
core +1 more source
F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj +1 more source
Antigen identification for orphan T cell receptors expressed on tumor-infiltrating lymphocytes
Cell, 2017 Summary The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood.
Marvin H. Gee +19 more
semanticscholar +1 more source
II. Detection of an antigen on resting T cells down-regulated after activation [PDF]
, 1987 The expression of an antigen on porcine T lymphocytes detected by murine monoclonal antibody (mAb) 8/1 was investigated by functional studies and dual-parameter immunofluorescence.
Saalmüller, Armin +4 more
core +1 more source
High-throughput determination of the antigen specificities of T cell receptors in single cells
Nature Biotechnology, 2018 We present tetramer-associated T-cell receptor sequencing (TetTCR-seq) to link T cell receptor (TCR) sequences to their cognate antigens in single cells at high throughput.
Shuqi Zhang +8 more
semanticscholar +1 more source
Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours
Nature Reviews Clinical Oncology, 2022 Therapies with genetically modified T cells that express chimeric antigen receptors (CARs) specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell malignancies.
Christian L. Flugel +6 more
semanticscholar +1 more source
Studies on the affinity control of T cell development [PDF]
, 2004 Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
core +1 more source
Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific [PDF]
, 1998 Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells.
Ogg, GS +22 more
core +1 more source
EBioMedicine, 2016 Dendritic cells (DCs) are major antigen-presenting cells that can efficiently prime and cross-prime antigen-specific T cells. Delivering antigen to DCs via surface receptors is thus an appealing strategy to evoke cellular immunity.
Wenjie Yin +15 more
doaj +1 more source