Results 11 to 20 of about 3,681,633 (268)

T–cell anergy and peripheral T–cell tolerance [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
The discovery that T–cell recognition of antigen can have distinct outcomes has advanced understanding of peripheral T–cell tolerance, and opened up new possibilities in immunotherapy. Anergy is one such outcome, and results from partial T–cell activation.
R, Lechler, J G, Chai, F, Marelli-Berg, G, Lombardi   +3 more
openaire   +2 more sources

Persistent immune activation in CVID and the role of IVIg in its suppression

Frontiers in Immunology, 2014
Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as ...
Dominic ePaquin-Proulx, Johan K. Sandberg   +1 more
doaj   +1 more source

HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread

eLife, 2020
The female reproductive tract (FRT) is the most common site of infection during HIV transmission to women, but viral remodeling complicates characterization of cells targeted for infection.
Tongcui Ma, Xiaoyu Luo, Ashley F George, Gourab Mukherjee, Nandini Sen, Trimble L Spitzer, Linda C Giudice, Warner C Greene, Nadia R Roan   +8 more
doaj   +1 more source

T cell aging: A review of the transcriptional changes determined from genome-wide analysis

Frontiers in Immunology, 2013
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells ...
Guobing eChen, Ana eLustig, Nan-ping eWeng   +2 more
doaj   +1 more source

Gynura procumbens ethanol extract and its fractions inhibit Th1, Th2 and Th17 but induce Treg cells differentiation during atherosclerosis development [PDF]

Journal of HerbMed Pharmacology, 2021
Introduction: Gynura procumbens (Lorr.) Merr. (GP) displays cardio-protective effect, which may hinder atherogenesis induced by oxidized low-density lipoprotein (oxLDL) and leukocytes.
Manimegalai Manogaran, Vuanghao Lim, Doblin Sandai, Rafeezul Mohamed   +3 more
doaj   +1 more source

Naïve, Effector, and Memory T cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting [PDF]

International Journal of Nutrition Sciences
Background: Intermittent fasting (IF) is a 16/8 fasting model, which is supposed to recruit immune cells to the bone marrow, thus prevents immune exhaustion.
Sara Assadiasl, Narjes Soleimanifar, Mohammad Hassan Alamolhoda, Hanieh Mojtahedi, Maryam Sadr, Sepehr Safdel, Zahra Mozooni, Mohammad Hossein Nicknam   +7 more
doaj   +1 more source

T lymphocytes development and aging

生物医学转化, 2023
T lymphocytes, as a vital component of the adaptive immune system, play a crucial role in maintaining immune health. A thorough investigation of their maturation and aging processes is essential for achieving a comprehensive understanding of the immune ...
Mao Lipeng, Luo Junhong, Chen Guobing
doaj   +1 more source

The T‐cell receptor repertoire of regulatory T cells [PDF]

Immunology, 2008
SummaryThe CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases.
Rafal, Pacholczyk, Joanna, Kern
openaire   +2 more sources

Donor T cells for CAR T cell therapy

Biomarker Research, 2022
AbstractAdoptive cell therapy using patient-derived chimeric receptor antigen (CAR) T cells redirected against tumor cells has shown remarkable success in treating hematologic cancers. However, wider accessibility of cellular therapies for all patients is needed.
Tang, TCY, Xu, N, Nordon, R, Haber, M, Micklethwaite, K, Dolnikov, A   +5 more
openaire   +4 more sources

Chimeric antigen receptor (CAR) T cells for the treatment of a kidney transplant patient with post-transplant lymphoproliferative disorder (PTLD)

Human Vaccines & Immunotherapeutics, 2023
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication following kidney transplantation, and there is a critical and unmet need for PTLD treatments associated with more pronounced and durable responses.
Kathryn Kline, Wengen Chen, Michael E. Kallen, Rima Koka, Destiny Omili, Xiaoxuan Fan, Thierry Iraguha, Etse Gebru, Nishanthini Dishanthan, Jillian M. Baker, Kenneth A. Dietze, Jean A. Yared, Kim Hankey, Saurabh Dahiya, Silke V. Niederhaus, Kieron Dunleavy, Nancy M. Hardy, Tim Luetkens, Aaron P. Rapoport, Djordje Atanackovic   +19 more
doaj   +1 more source