Results 11 to 20 of about 17,623,577 (306)

Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis

Nature Communications, 2023
Regulatory T cells (Treg) are CD4+ T cells with immune-suppressive function, which is defined by Foxp3 expression. However, the molecular determinants defining the suppressive population of T cells have yet to be discovered.
Jae-Seung Moon, Chun-Chang Ho, Jong-Hyun Park, Kyungsoo Park, Bo-Young Shin, Su-Hyeon Lee, Ines Sequeira, Chin Hee Mun, Jin-Su Shin, Jung-Ho Kim, Beom Seok Kim, Jin-Wook Noh, Eui-Seon Lee, Ji Young Son, Yuna Kim, Yeji lee, Hee Cho, SunHyeon So, Jiyoon Park, Eunsu Choi, Jong-Won Oh, Sang-Won Lee, Tomohiro Morio, Fiona M. Watt, Rho Hyun Seong, Sang-Kyou Lee   +25 more
doaj   +1 more source

Age-Related Gene Alteration in Naïve and Memory T cells Using Precise Age-Tracking Model

Frontiers in Cell and Developmental Biology, 2021
In aged individuals, age-related changes in immune cells, especially T cell deficiency, are associated with an increased incidence of infection, tumor, and autoimmune disease, as well as an impaired response to vaccination.
Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xin Wang, Xin Wang, Xin Wang, Lei Lei, Lei Lei, Lei Lei, Lina Sun, Lina Sun, Anjun Jiao, Anjun Jiao, Anjun Jiao, Kun Zhu, Kun Zhu, Tao Xie, Tao Xie, Haiyan Liu, Haiyan Liu, Xingzhe Zhang, Xingzhe Zhang, Yanhong Su, Yanhong Su, Cangang Zhang, Cangang Zhang, Lin Shi, Lin Shi, Dan Zhang, Dan Zhang, Huiqiang Zheng, Huiqiang Zheng, Jiahui Zhang, Jiahui Zhang, Xiaobin Liu, Xiaobin Liu, Xin Wang, Xin Wang, Xiaobo Zhou, Xiaobo Zhou, Chenming Sun, Chenming Sun, Baojun Zhang, Baojun Zhang, Baojun Zhang   +44 more
doaj   +1 more source

Interplay between SMAD2 and STAT5A is a critical determinant of IL-17A/IL-17F differential expression

Molecular Biomedicine, 2021
Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells, but the underlying mechanisms remain ...
Karla Fabiola Corral-Jara, Camille Chauvin, Wassim Abou-Jaoudé, Maximilien Grandclaudon, Aurélien Naldi, Vassili Soumelis, Denis Thieffry   +6 more
doaj   +1 more source

Determination of the level of CD4CD69 T cells in hemodialysis patients

Journal of Medicine in Scientific Research, 2022
Introduction The CD4 helper T cell is responsible for humoral, cellular immunity, and inflammation. CD69 may be a sensitive marker indicating that the CD4 T cell is activated.
Azza A I. Elmenyawi, Ahmed A A. Megeed, Nehad R Ibrahim, Mohamed Salah   +3 more
doaj   +1 more source

Freeze-thaw lysates of P. falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
: In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to T-cell receptor stimulation with cytokine co-stimulation ...
Finney, OC, Walther, M, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +5 more
core   +3 more sources

Deciphering the combinatorial landscape of immunity

eLife, 2020
From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes.
Antonio Cappuccio, Shane T Jensen, Boris M Hartmann, Stuart C Sealfon, Vassili Soumelis, Elena Zaslavsky   +5 more
doaj   +1 more source

Comparing Mouse and Human Tissue-Resident γδ T Cells

Frontiers in Immunology, 2022
Circulating immune cell compartments have been extensively studied for decades, but limited access to peripheral tissue and cell yield have hampered our understanding of tissue-based immunity, especially in γδ T cells. γδ T cells are a unique subset of T
Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao, Jing Luo   +5 more
doaj   +1 more source

Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity

OncoImmunology, 2021
Intratumoral heterogeneity is frequently associated with tumor immune escape, with MHC-class I and antigen expression loss rendering tumor cells invisible to T cell killing, representing a major challenge for the design of successful adoptive transfer ...
Margareta P. Correia, Ana Stojanovic, Winfried S. Wels, Adelheid Cerwenka   +3 more
doaj   +1 more source

Donor T cells for CAR T cell therapy

Biomarker Research, 2022
AbstractAdoptive cell therapy using patient-derived chimeric receptor antigen (CAR) T cells redirected against tumor cells has shown remarkable success in treating hematologic cancers. However, wider accessibility of cellular therapies for all patients is needed.
Tang, TCY, Xu, N, Nordon, R, Haber, M, Micklethwaite, K, Dolnikov, A   +5 more
openaire   +4 more sources

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core   +7 more sources