Results 11 to 20 of about 41,042,307 (363)

Multiple steady states and the form of response functions to antigen in a model for the initiation of T-cell activation [PDF]

Royal Society Open Science, 2017
The aim of this paper is to study the qualitative behaviour predicted by a mathematical model for the initial stage of T-cell activation. The state variables in the model are the concentrations of phosphorylation states of the T-cell receptor (TCR ...
Alan D. Rendall, Eduardo D. Sontag
doaj   +1 more source

Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies

Cancer Biology & Medicine, 2021
Tertiary lymphoid structures (TLSs) are ectopic immune cell aggregations that develop in peripheral tissues in response to a wide range of chronic inflammatory conditions, including infection, autoimmune disease, and cancer. In the tumor microenvironment
Hua Zhao, Hao Wang, Qiuru Zhou, Xiubao Ren   +3 more
doaj   +1 more source

Immune, metabolism and therapeutic targets in RA (Rheumatoid Arthritis) [PDF]

BIO Web of Conferences, 2022
Rheumatoid arthritis is a classic autoimmune disease, the pathogenesis of which is closely linked to the auto-reactivity of immune cells and joint inflammation. Three cell types, namely T cells, macrophages and fibroblast-like synoviocytes (FLS), play an
Liu Keying
doaj   +1 more source

TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Nature, 2018
Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer.
S. Mariathasan, S. Turley, D. Nickles, A. Castiglioni, Kobe Yuen, Yulei Wang, E. Kadel, H. Koeppen, Jillian L. Astarita, R. Cubas, S. Jhunjhunwala, R. Banchereau, Ya-Gai Yang, Y. Guan, Cecile Chalouni, J. Ziai, Y. Şenbabaoğlu, Stephen P. Santoro, D. Sheinson, Jeffrey Hung, J. Giltnane, A. Pierce, Kathryn Mesh, Steve Lianoglou, Johannes Riegler, R. Carano, P. Eriksson, M. Höglund, Loan Somarriba, D. Halligan, M. S. van der Heijden, Y. Loriot, J. Rosenberg, L. Fong, I. Mellman, Daniel S. Chen, M. Green, C. Derleth, G. Fine, P. Hegde, Richard Bourgon, T. Powles   +41 more
semanticscholar   +1 more source

T–cell anergy and peripheral T–cell tolerance [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
The discovery that T–cell recognition of antigen can have distinct outcomes has advanced understanding of peripheral T–cell tolerance, and opened up new possibilities in immunotherapy. Anergy is one such outcome, and results from partial T–cell activation.
R, Lechler, J G, Chai, F, Marelli-Berg, G, Lombardi   +3 more
openaire   +2 more sources

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

Rapid turnover of effector-memory CD4(+) T cells in healthy humans [PDF]

, 2004
Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar ...
Peter C.L. Beverley, Macallan, DC, Griffin, GE, George E. Griffin, Andrew T. Worth, Derek C. Macallan, Wallace, Diana, Diana Wallace, Ghattas, Hala, Zhang, Yan, Griffin, George E, Macallan, Derek C, Zhang, Y, Ghattas, H, Beverley, Peter CL, Tough, David F, Hala Ghattas, Tough, DF, David F. Tough, De Lara, C, De Lara, Catherine, Beverley, PC, Yan Zhang, Catherine de Lara, Wallace, D, Worth, Andrew T, Worth, AT   +26 more
core   +1 more source

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

New England Journal of Medicine, 2014
BACKGROUND Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor–modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce ...
S. Maude, N. Frey, P. Shaw, R. Aplenc, D. Barrett, N. Bunin, A. Chew, Vanessa E. Gonzalez, Zhaohui Zheng, S. Lacey, Yolanda D. Mahnke, J. Melenhorst, S. Rheingold, Angela Shen, D. Teachey, B. Levine, C. June, D. Porter, S. Grupp   +18 more
semanticscholar   +1 more source

Persistent immune activation in CVID and the role of IVIg in its suppression

Frontiers in Immunology, 2014
Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as ...
Dominic ePaquin-Proulx, Johan K. Sandberg   +1 more
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HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread

eLife, 2020
The female reproductive tract (FRT) is the most common site of infection during HIV transmission to women, but viral remodeling complicates characterization of cells targeted for infection.
Tongcui Ma, Xiaoyu Luo, Ashley F George, Gourab Mukherjee, Nandini Sen, Trimble L Spitzer, Linda C Giudice, Warner C Greene, Nadia R Roan   +8 more
doaj   +1 more source