Results 41 to 50 of about 312,631 (303)

CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

Frontiers in Immunology, 2017
The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained.
Giuliana Roselli, Elisa Martini, Vassilios Lougaris, Raffaele Badolato, Antonella Viola, Antonella Viola, Marinos Kallikourdis, Marinos Kallikourdis   +7 more
doaj   +1 more source

Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity [PDF]

, 2015
EC is supported by the Alexander von Humboldt Foundation, the German Federal Ministry for Education and Research, the Helmholtz Association, the Göran Gustafsson Foundation, the Swedish Research Council, the Kempe Foundation and Umeå University.
White, Malcolm F., Charpentier, Emmanuelle, White, Malcolm F, van der Oost, John, Richter, Hagen   +4 more
core   +1 more source

Role of platelets and megakaryocytes in adaptive immunity [PDF]

, 2021
The immune system is comprised of two principal interconnected components called innate and adaptive immunity. While the innate immune system mounts a nonspecific response that provides protection against the spread of foreign pathogens, the adaptive ...
Genevieve Marcoux, Audrée Laroche, Jenifer Espinoza Romero, Eric Boilard   +3 more
core   +1 more source

Adaptation and Immunity

PLoS Biology, 2004
The ongoing battle between hosts and pathogens has long been of interest to evolutionary biologists.
openaire   +4 more sources

Gammadelta T cells: novel initiators of adaptive immunity [PDF]

, 2007
In this review, we discuss the potential role of human gammadelta T cells in the control of adaptive immunity. Our latest findings emerged as a consequence of our working hypothesis, which predicts a close relationship between the migration control in ...
Eberl, Matthias, Eberl, M, Moser, Bernhard, Bernhard Moser, Matthias Eberl   +4 more
core   +1 more source

Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Cell Reports, 2020
Summary: Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses.
Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek   +8 more
doaj   +1 more source

Innate immunity against HIV: a priority target for HIV prevention research. [PDF]

, 2010
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W, ROMARIS M, LINDBLAD E, DONCEL G, BORROW P, Persephone Borrow, Borrow, P, LEHNER T, DE MAGISTRIS MT, Shattock, Robin J., MEDAGLINI, DONATA, Vyakarnam, Annapurna, PATTERSON S, Annapurna Vyakarnam, POLI G, EUROPRISE WORKING GROUP BOGERS W, KIRCHHOFF F, KELLY C, TOWERS G, SILVESTRI G, DEBRE P, Robin J Shattock, Shattock, RJ, SHATTOCK RJ, Vyakarnam Annapurna, Borrow, Persephone, Borrow Persephone, GOODIER M, null null, SPECK R, EUROPRISE Working Group, GEIJTENBEEK T, Vyakarnam, A, Shattock Robin J, WAGNER H., VYAKARNAM A   +35 more
core   +1 more source

Blurring Borders: Innate Immunity with Adaptive Features [PDF]

, 2007
Adaptive immunity has often been considered the penultimate of immune capacities. That system is now being deconstructed to encompass less stringent rules that govern its initiation, actual effector activity, and ambivalent results.
Cooper, EL, Bovári-Biri, Judit, Bovari, J, Kvell, K, P. Engelmann, EL. Cooper, Engelmann, Péter, J. Bovari, K. Kvell, P. Nemeth, Nemeth, P, Engelmann, P, Kvell, Krisztian, Németh, Péter   +13 more
core   +1 more source

Method for identification of condition-associated public antigen receptor sequences

eLife, 2018
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease ...
Mikhail V Pogorelyy, Anastasia A Minervina, Dmitriy M Chudakov, Ilgar Z Mamedov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak   +6 more
doaj   +1 more source

Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease

Frontiers in Immunology, 2020
The evolution of the full range of functions of regulatory T cells (Treg) coincides with the evolution of mammalian pregnancy. Accordingly, Treg function has been shown to be crucial for maternal-fetal tolerance and implantation. As reproduction is a key
Elisa Martini, Silvia Giugliano, Silvia Giugliano, Maria Rescigno, Maria Rescigno, Marinos Kallikourdis, Marinos Kallikourdis   +6 more
doaj   +1 more source