Results 61 to 70 of about 312,631 (303)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

1 Innate immunity and adaptive immunity.pdf [PDF]

, 2016
Defense against microbes is mediated by the early reactions of innate immunity and the later responses of adaptive immunity.
Yudong Lu (2618959)
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Framework for Annotation of Antigen Specificities in High-Throughput T-Cell Repertoire Sequencing Studies

Frontiers in Immunology, 2019
Recently developed molecular methods allow large-scale profiling of T-cell receptor (TCR) sequences that encode for antigen specificity and immunological memory of these cells.
Mikhail V. Pogorelyy, Mikhail V. Pogorelyy, Mikhail Shugay, Mikhail Shugay, Mikhail Shugay   +4 more
doaj   +1 more source

Advances in innate immune memory of macrophages

Exploration of Immunology, 2022
Immunity is usually classified into two categories: innate immunity and adaptive immunity, distinguished by the process and characteristics of the immunological impact. It was widely assumed that only adaptive immunity possessed memory features; however,
Safir Ullah Khan, Munir Ullah Khan
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus [PDF]

, 2013
Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD).
Francesco Trotta, Pitocco, Dario, Giovanna Liuzzo, Gianluca Massaro, Maria Teresa Cardillo, Ghirlanda, Giovanni, Zaccardi, Francesco, Cialdella, Pio, Francesca Martini, Martini, Francesca, Francesco Zaccardi, Simona Giubilato, Giglio, Ada Francesca, Filippo Crea, Liuzzo, Giovanna, Scavone, Giuseppe, Pio Cialdella, Pedicino, Daniela, Dario Pitocco, Giubilato, Simona, Ada Francesca Giglio, Giovanni Ghirlanda, Marco Previtero, Trotta, Francesco, Crea, Filippo, Daniela Pedicino, Cardillo, Maria Teresa, Giuseppe Scavone   +27 more
core   +1 more source

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

Frontiers in Pharmacology, 2019
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells.
Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther, Menno P.J. de Winther   +15 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Turning the Tables: Loss of Adaptive Immunity Reverses Sex Differences in Tuberculosis [PDF]

Sex-based differences in innate immunity may play a crucial role in susceptibility to and progression of tuberculosis (TB), a disease that disproportionately affects men.
Lars Eggers, David Hertz, Bianca E. Schneider, Linda von Borstel, Hanna Lotter, Torsten Goldmann   +5 more
core   +1 more source