Results 71 to 80 of about 505,030 (295)

T cell costimulation blockade blunts pressure overload-induced heart failure

Nature Communications, 2017
Abatacept is an FDA-approved drug used for treatment of rheumatoid arthritis. Here the authors show that abatacept reduces cardiomyocyte death in a mouse model of heart failure by inhibiting activation and heart infiltration of T cells and macrophages ...
Marinos Kallikourdis, Elisa Martini, Pierluigi Carullo, Claudia Sardi, Giuliana Roselli, Carolina M. Greco, Debora Vignali, Federica Riva, Anne Marie Ormbostad Berre, Tomas O. Stølen, Andrea Fumero, Giuseppe Faggian, Elisa Di Pasquale, Leonardo Elia, Cristiano Rumio, Daniele Catalucci, Roberto Papait, Gianluigi Condorelli   +17 more
doaj   +1 more source

The size of the immune repertoire of bacteria

, 2019
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past ...
Balasubramanian, Vijay, Bradde, Serena, Goyal, Sidhartha, Nourmohammad, Armita   +3 more
core   +1 more source

Wise Blood: The Principle of Overcoming in Disease and Immunity (Part 1) [PDF]

, 2020
The immune system is an intelligently made system designed for interaction with microbes even in a perfect world; it is more than a defense. However, in a post-fall world, it is primarily a body’s defense system.
Gillen, Alan L., Huy, Keoprommony
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

eLife
Suppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II.
Tatyana O Nakonechnaya, Bruno Moltedo, Ekaterina V Putintseva, Sofya Leyn, Dmitry A Bolotin, Olga V Britanova, Mikhail Shugay, Dmitriy M Chudakov   +7 more
doaj   +1 more source

In the eye of the storm: T cell behavior in the inflammatory microenvironment. [PDF]

, 2013
Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently ...
Haas, R, Marelli-Berg, F, Mauro, C
core   +1 more source

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]

, 2018
The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda, Celias, Daiana Pamela, Cervi, Laura Alejandra, Chiapello, Laura Silvina, Motran, Claudia Cristina, Silvane, Leonardo Micael, Theumer, Martín Gustavo, Volpini, Ximena   +7 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

‘Cannibalism’ of exogenous DNA sequences: The ancestral form of adaptive immunity which entails recognition of danger

Frontiers in Immunology, 2022
Adaptive immunity is a sophisticated form of immune response capable of retaining the molecular memory of a very great diversity of target antigens (epitopes) as non-self.
Christian A. Devaux, Christian A. Devaux, Pierre Pontarotti, Pierre Pontarotti, Sephora Nehari, Didier Raoult   +5 more
doaj   +1 more source

Nutrition, diet and immunosenescence [PDF]

, 2013
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
Agrawal, Agrawal, Akbar, Almanzar, Alonso, Alperovich, Alvarez-Rodriguez, Arunachalam, Azzini, Bates, Bechoua, Belisle, Belisle, Berzins, Blomberg, Bogden, Borrego, Bouwens, Bravo, Buffa, Bunout, Butcher, Calder, Camous, Canaday, Cannizzo, Carluccio, Castle, Cevenini, Chandra, Chatta, Chidrawar, Chung, Ciaramella, Clambey, Clark, Claudio Nicoletti, Colonna-Romano, Corridan, Corsini, Cortes, Cossack, Currier, De La Fuente, De la Fuente, De la Fuente, De Martinis, DelaRosa, DelaRosa, Della Bella, Dell’Agli, Dewan, Di Lorenzo, Dong, Donnini, Dorshkind, Dubey, Duchateau, Dunn-Walters, Effros, Enos, Estruch, Farges, Fateh, Faunce, Fearnley, Feart, Fietta, Flores, Fortes, Fortin, Fortin, Franceschi, Franceschi, Frasca, Frasca, Fulop, Fulop, Fulop, Fulop, Galli, Gao, Gayoso, Gebremichael, Gibson, Gibson, Gill, Gill, Ginaldi, Gomez, Goronzy, Goronzy, Guigoz, Guigoz, Hadziabdic, Hakim, Hamilton-Miller, Haynes, Haynes, Haynes, Herndler-Brandstetter, Herrero, Herrero, Hilmer, Hodkinson, Hong, Ishimoto, Jing, Kahmann, Kamal Ivory, Khan, Kowdley, Larbi, Larbi, Lasheras, Le Garff-Tavernier, Lee, Lesourd, Lesourd, Ligthart, Lung, Magrone, Mariani, Mariani, Martinez-Gonzalez, Maue, McElhaney, Merchant, Meydani, Meydani, Meydani, Meydani, Mitchell, Monagas, Murasko, Mysliwska, Mònica Maijó, Nagel, Nicoletti, Nicoletti, Nikolich-Zugich, Nova, Nova, Ogawa, Ogawa, Osler, Ouwehand, Ouwehand, Pae, Paganelli, Pallast, Pawelec, Peralbo, Peralbo, Pfister, Plackett, Plowden, Prakash, Prasad, Prasad, Prasad, Prasad, Psaltopoulou, Pérez-Cabezas, Rees, Rink, Salas-Salvado, Sarah J. Clements, Saule, Saurwein-Teissl, Scarmeas, Scarmeas, Schenkein, Schiffrin, Schiffrin, Schwaiger, Shaw, Shodell, Simon R. Carding, Sofi, Sofi, Solana, Solana, Solana, Sridharan, Steger, Stout-Delgado, Swift, Tangney, Tasat, Tortorella, Tortorella, Trichopoulou, Uyemura, Valls-Pedret, van Duin, Varas, Vasto, Vasto, Vetvicka, Vulevic, Waitzberg, Wallace, Watson, Webster, Weiskopf, Weksler, Wenisch, Wikby, Willett, Wong, Wordsworth, Wu, Yaqoob, Yaqoob, Yuan, Zanni, Zissel   +217 more
core   +1 more source