Results 1 to 10 of about 34,505 (262)
Human TCR repertoire in cancer [PDF]
Cancer MedicineBackground T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses.
Lin Chen +4 more
doaj +5 more sources
Circulating gluten‐specific, but not CMV‐specific, CD39+ regulatory T cells have an oligoclonal TCR repertoire [PDF]
Clinical and Translational Immunology, 2020 Objectives Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T‐cell (Treg) populations is important for strategies aiming to re‐establish tolerance in autoimmune diseases. We studied circulating deamidated gluten‐epitope‐specific CD39+
Laura Cook +2 more
exaly +5 more sources
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis) [PDF]
BMC Genomics, 2022 Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research.
Swati Jaiswal +14 more
doaj +3 more sources
BMC Bioinformatics, 2022 Background T cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to examine the T cell receptor (TCR) repertoire at the individual sequence level.
Meiling Liu +6 more
doaj +2 more sources
End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8+ T Cell Subsets
Frontiers in Immunology, 2017 A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell ...
Michiel G H Betjes +2 more
exaly +3 more sources
Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire [PDF]
iScienceSummary: HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their T cell receptor (TCR) are termed donor-unrestricted T cells due to restricted allelic ...
Linda Voogd +14 more
doaj +2 more sources
Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions [PDF]
Seminars in Immunology, 2023 Nan-Ping Weng
exaly +2 more sources
Frontiers in Immunology, 2021 Temporal analysis of the T cell receptor (TCR) repertoire has been used to monitor treatment-induced changes in antigen-specific T cells in patients with cancer.
Mikiya Tsunoda +7 more
doaj +1 more source
Quantifying Distribution of Flow Cytometric TCR-Vβ Usage with Economic Statistics. [PDF]
PLoS ONE, 2015 Measuring changes of the T cell receptor (TCR) repertoire is important to many fields of medicine. Flow cytometry is a popular technique to study the TCR repertoire, as it quickly provides insight into the TCR-Vβ usage among well-defined populations of T
Kornelis S M van der Geest +10 more
doaj +1 more source
T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma
Current Issues in Molecular Biology, 2023 Immune checkpoint inhibitors (ICIs) are effective in treating renal cell carcinoma (RCC) but can also cause immune-related adverse events (irAEs). The relationship between irAEs and the T-cell receptor (TCR) repertoire in RCC patients treated with ICIs ...
Takuro Kobayashi +6 more
doaj +1 more source