Results 1 to 10 of about 206,427 (253)

Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

Frontiers in Immunology, 2017
Respiratory support improvements have aided survival of premature neonates, but infection susceptibility remains a predominant problem. We previously reported that neonatal mice have a rapidly evolving T-cell receptor (TCR) repertoire that impairs CD8+ T
Alison J. Carey, Alison J. Carey, Jennifer L. Hope, Jennifer L. Hope, Yvonne M. Mueller, Adam J. Fike, Ogan K. Kumova, David B. H. van Zessen, David B. H. van Zessen, Eric A. P. Steegers, Mirjam van der Burg, Peter D. Katsikis   +11 more
doaj   +1 more source

Reduced diversity of intestinal T-cell receptor repertoire in patients with Crohn’s disease

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundThe intestinal microenvironment directly determines the human T-cell receptor (TCR) repertoire. Despite its extreme diversity, TCR repertoire analysis may provide a better understanding of the immune system in patients with inflammatory bowel ...
Sung Noh Hong, Sung Noh Hong, Joo-Young Park, So-Yun Yang, Chansu Lee, Chansu Lee, Young-Ho Kim, Je-Gun Joung   +7 more
doaj   +1 more source

The TCR Repertoire of an Immunodominant CD8+ T Lymphocyte Population [PDF]

The Journal of Immunology, 2001
Abstract The TCR repertoire of an epitope-specific CD8+ T cell population remains poorly characterized. To determine the breadth of the TCR repertoire of a CD8+ T cell population that recognizes a dominant epitope of the AIDS virus, the CD8+ T cells recognizing the tetrameric Mamu-A*01/p11C,CM complex were isolated from simian ...
Z W, Chen, Y, Li, X, Zeng, M J, Kuroda, J E, Schmitz, Y, Shen, X, Lai, L, Shen, N L, Letvin   +8 more
openaire   +2 more sources

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology
Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases.
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
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Peripheral Blood TCR Clonotype Diversity as a Biomarker for Colorectal Cancer

Bioengineering
There exists an urgent need to improve colorectal cancer (CRC) diagnosis due to limitations in current diagnostic approaches. Systematic characterization of the human T cell receptor (TCR) repertoire, coupled with advanced computational methods, provides
Gaochen Zhu, Tao Chen, Chen Ma, Kai Liu, Bihui Huang, Guan Yang   +5 more
doaj   +1 more source

IMonitor: A Robust Pipeline for TCR and BCR Repertoire Analysis [PDF]

Genetics, 2015
Abstract The advance of next generation sequencing (NGS) techniques provides an unprecedented opportunity to probe the enormous diversity of the immune repertoire by deep sequencing T-cell receptors (TCRs) and B-cell receptors (BCRs). However, an efficient and accurate analytical tool is still on demand to process the huge amount of data.
Zhang, Wei, Du, Yuanping, Su, Zheng, Wang, Changxi, Zeng, Xiaojing, Zhang, Ruifang, Hong, Xueyu, Nie, Chao, Wu, Jinghua, Cao, Hongzhi, Xu, Xun, Liu, Xiaoli   +11 more
openaire   +3 more sources

Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification.

PLoS Computational Biology
Insights gained through interpretation of models trained on the T-cell receptor (TCR) repertoire contribute to advances in understanding of immune-mediated disease.
Hannah Kockelbergh, Shelley C Evans, Liam Brierley, Peter L Green, Andrea L Jorgensen, Elizabeth J Soilleux, Anna Fowler   +6 more
doaj   +1 more source

Novel NHEJ1 pathogenic variant linked to severe combined immunodeficiency, microcephaly, and abnormal T and B cell receptor repertoires

Frontiers in Pediatrics, 2022
BackgroundDuring the process of generating diverse T and B cell receptor (TCR and BCR, respectively) repertoires, double-strand DNA breaks are produced.
Shirly Frizinsky, Shirly Frizinsky, Erez Rechavi, Erez Rechavi, Ortal Barel, Yu Nee Lee, Yu Nee Lee, Amos J. Simon, Amos J. Simon, Atar Lev, Atar Lev, Tali Stauber, Tali Stauber, Tali Stauber, Etai Adam, Raz Somech, Raz Somech, Raz Somech   +17 more
doaj   +1 more source

Revealing individual signatures of human T cell CDR3 sequence repertoires with Kidera Factors.

PLoS ONE, 2014
The recent development of High Throughput Sequencing technologies has enabled an individual's TCR repertoire to be efficiently analysed at the nucleotide level. However, with unique clonotypes ranging in the tens of millions per individual, this approach
Michael Epstein, Martino Barenco, Nigel Klein, Michael Hubank, Robin E Callard   +4 more
doaj   +1 more source

Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)

BMC Genomics, 2022
Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research.
Swati Jaiswal, Sarah K. Nyquist, Shayla Boyce, Tasneem Jivanjee, Samira Ibrahim, Joshua D. Bromley, G. James Gatter, Hannah Gideon, Kush Patel, Sharie Keanne Ganchua, Bonnie Berger, Sarah M. Fortune, JoAnne L. Flynn, Alex K. Shalek, Samuel M. Behar   +14 more
doaj   +1 more source