Results 1 to 10 of about 30,633 (227)
Human TCR repertoire in cancer [PDF]
Cancer MedicineBackground T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses.
Lin Chen +4 more
doaj +4 more sources
TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs [PDF]
Cell Reports Methods, 2023 T cell receptor (TCR) technologies, including repertoire analyses and T cell engineering, are increasingly important in the clinical management of cellular immunity in cancer, transplantation, and other immune diseases. However, sensitive and reliable methods for repertoire analyses and TCR cloning are still lacking.
Raphaël Genolet +2 more
exaly +3 more sources
Machine Learning Approaches to TCR Repertoire Analysis. [PDF]
Front Immunol, 2022 Sparked by the development of genome sequencing technology, the quantity and quality of data handled in immunological research have been changing dramatically. Various data and database platforms are now driving the rapid progress of machine learning for immunological data analysis.
Katayama Y +3 more
europepmc +4 more sources
Exploiting TCR Repertoire Analysis to Select Therapeutic TCRs for Cancer Immunotherapy. [PDF]
CellsOver the past decade, numerous innovative immunotherapy strategies have transformed the treatment of cancer and improved the survival of patients unresponsive to conventional chemotherapy and radiation therapy. Immune checkpoint inhibition approaches aim to block negative regulatory pathways that limit the function of endogenous T cells, while adoptive
Demaël UM +4 more
europepmc +3 more sources
Genetic and environmental determinants of human TCR repertoire diversity [PDF]
Immunity & Ageing, 2020 T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major histocompatibility (MHC) molecules. However,
Chirag Krishna +4 more
doaj +3 more sources
Deciphering the TCR Repertoire to Solve the COVID-19 Mystery [PDF]
Trends in Pharmacological Sciences, 2020 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date. Important questions have remained unanswered: why some patients develop severe disease, while others do not; and what roles do genetic variabilities play in the individual immune response to this ...
Houda Alachkar
exaly +3 more sources
A comprehensive evaluation of diversity measures for TCR repertoire profiling. [PDF]
BMC BiolAbstract Background T cells play a crucial role in adaptive immunity, as they monitor internal and external immunogenic signals through their specific receptors (TCRs). Using high-throughput sequencing, one can assess TCR repertoire in various clinical settings and describe it quantitatively by calculating a diversity
Mika J +6 more
europepmc +4 more sources
Clinical and Translational Immunology, 2020 Objectives Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T‐cell (Treg) populations is important for strategies aiming to re‐establish tolerance in autoimmune diseases. We studied circulating deamidated gluten‐epitope‐specific CD39+
Jason Tye-Din +2 more
exaly +2 more sources
Exploring the potential of the TCR repertoire as a tumor biomarker (Review). [PDF]
Oncol LettT cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T-cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells.
Huang AL +5 more
europepmc +3 more sources
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis) [PDF]
BMC Genomics, 2022 Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research.
Swati Jaiswal +14 more
doaj +2 more sources