Results 1 to 10 of about 58,670 (191)

End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8+ T Cell Subsets [PDF]

Frontiers in Immunology, 2017
A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell ...
Michiel G H Betjes, Mariska klepper, Anton W Langerak   +2 more
exaly   +5 more sources

Human TCR repertoire in cancer [PDF]

Cancer Medicine
Background T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses.
Lin Chen, Yuan Hu, Bohao Zheng, Limei Luo, Zhenzhen Su   +4 more
doaj   +2 more sources

Circulating gluten‐specific, but not CMV‐specific, CD39+ regulatory T cells have an oligoclonal TCR repertoire

Clinical and Translational Immunology, 2020
Objectives Understanding the T cell receptor (TCR) repertoire of regulatory CD4+ T‐cell (Treg) populations is important for strategies aiming to re‐establish tolerance in autoimmune diseases. We studied circulating deamidated gluten‐epitope‐specific CD39+
Laura Cook, C Mee Ling Munier, Nabila Seddiki   +2 more
exaly   +2 more sources

Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis) [PDF]

BMC Genomics, 2022
Background Cynomolgus macaque (Macaca fascicularis) is an attractive animal model for the study of human disease and is extensively used in biomedical research.
Swati Jaiswal, Sarah K. Nyquist, Shayla Boyce, Tasneem Jivanjee, Samira Ibrahim, Joshua D. Bromley, G. James Gatter, Hannah Gideon, Kush Patel, Sharie Keanne Ganchua, Bonnie Berger, Sarah M. Fortune, JoAnne L. Flynn, Alex K. Shalek, Samuel M. Behar   +14 more
doaj   +2 more sources

Peripheral blood TCR repertoire improves early detection across multiple cancer types utilizing a cancer predictor. [PDF]

Front Oncol
Tang Y, Liao X, Liao B, Peng D, Li Q.
europepmc   +3 more sources

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations. [PDF]

Front Immunol
Salnikova MA, Tuchynskaya KK, Minervina AA, Pogorelyy MV, Okhezin EV, Karganova GG, Mamedov IZ, Lebedev YB.   +7 more
europepmc   +3 more sources

Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire [PDF]

iScience
Summary: HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their T cell receptor (TCR) are termed donor-unrestricted T cells due to restricted allelic ...
Linda Voogd, Anne M.H.F. Drittij, Calinda K.E. Dingenouts, Kees L.M.C. Franken, Vincent van Unen, Krista E. van Meijgaarden, Paula Ruibal, Renate S. Hagedoorn, Judith A. Leitner, Peter Steinberger, Mirjam H.M. Heemskerk, Mark M. Davis, Thomas J. Scriba, Tom H.M. Ottenhoff, Simone A. Joosten   +14 more
doaj   +2 more sources

Numbers and odds: TCR repertoire size and its age changes impacting on T cell functions [PDF]

Seminars in Immunology, 2023
Nan-Ping Weng
exaly   +2 more sources

Chain-specific remodeling of the γδ T-cell TCR repertoire in preterm infants with cCMV: a gestational-age-stratified case-control study. [PDF]

Front Immunol
Liu P, Zou R, Zhao J, Zhang Y, Liu Y, Tang P, Wu K, Gao X.   +7 more
europepmc   +3 more sources

Clonal Distribution and Intratumor Heterogeneity of the TCR Repertoire in Papillary Thyroid Cancer With or Without Coexistent Hashimoto's Thyroiditis. [PDF]

Front Immunol, 2022
Cui L, Zhang C, Ding H, Feng D, Huang H, Lu Z, Liu B.   +6 more
europepmc   +2 more sources