Results 1 to 10 of about 242,999 (280)

Immune repertoire profiling and T cell dysregulation in Peripheral Blood Mononuclear Cells of Type 2 diabetic patients. [PDF]

PLoS ONE
ObjectiveThe prevalence of diabetes mellitus (DM) is escalating globally, presenting a significant public health challenge. The immune system, particularly T cells, plays a crucial role in the pathogenesis of diabetes.
Zheng Bi, Fanjing Wang, Shengmao Wang, Zhaohui Fang   +3 more
doaj   +2 more sources

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history [PDF]

Communications Biology
Conventional T cells recognize peptides presented by the human leukocyte antigen (HLA) proteins through their T cell receptors (TCRs). Given that thousands of HLA proteins have been discovered, each presenting thousands of different peptides, decoding ...
Hesham ElAbd, Aya K. H. Mahdy, Eike Matthias Wacker, Maria Gretsova, David Ellinghaus, Astrid Dempfile, Andre Franke   +6 more
doaj   +2 more sources

A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy. [PDF]

PLoS ONE, 2016
Aurora Kinase A is a cancer-associated protein normally involved in the regulation of mitosis. Being over-expressed in a range of cancers, it is a suitable target for cell-based immunotherapy. Gene transfer of T-cell receptor sequences cognisant of HLA-A*
Nicholas Paul Casey, Hiroshi Fujiwara, Kazushi Tanimoto, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa   +7 more
doaj   +1 more source

Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone. [PDF]

The Journal of experimental medicine, 1988
A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers.
L A, Matis, A, Ezquerra, J E, Coligan
openaire   +2 more sources

Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.

PLoS Computational Biology, 2021
The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients contain antigen receptors able to specifically identify tumor cells.
Miri Gordin, Hagit Philip, Alona Zilberberg, Moriah Gidoni, Raanan Margalit, Christopher Clouser, Kristofor Adams, Francois Vigneault, Irun R Cohen, Gur Yaari, Sol Efroni   +10 more
doaj   +1 more source

Rearrangement and expression of the antigen receptor alpha, beta and gamma genes in suppressor antigen-specific T cell lines. [PDF]

The EMBO Journal, 1985
The rearrangement and transcription of the antigen receptor alpha, beta and gamma genes were investigated in murine antigen-specific suppressor T cell lines, to establish whether the suppressor T cell subset expresses the same antigen receptor transcripts previously found in helper and cytotoxic T lymphocytes.
MORI L, LECOQ A F, ROBBIATI F, BARBANTI E, RIGHI M, SINIGAGLIA F, CLEMENTI F, RICCIARDICASTAGNOLI P   +7 more
openaire   +3 more sources

Targeting the melanoma-associated antigen CSPG4 with HLA-C*07:01-restricted T-cell receptors

Frontiers in Immunology, 2023
IntorductionChondroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight-melanoma associated antigen, is expressed in melanoma but also other tumor entities and constitutes an attractive target for immunotherapeutic approaches.
Korbinian N. Kropp, Martina Fatho, Enes Huduti, Marilena Faust, Silke Lübcke, Volker Lennerz, Annette Paschen, Matthias Theobald, Thomas Wölfel, Catherine Wölfel   +9 more
doaj   +1 more source

Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors [PDF]

Vojnosanitetski Pregled, 2011
Background/Aim. Hemophilia A patients with inhibitors are treated effectively with immune tolerance induction (ITI) therapy. Although anti-idiotypic antibodies may play a certain role in the underlying mechanism, the detailed mechanism by which ITI ...
Sakurai Yoshihiko, Matsutani Takaji, Yoshioka Takeshi, Takeda Tomohiro, Yoshioka Akira, Shima Midori   +5 more
doaj   +1 more source

A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery

Pharmaceutics, 2021
Autoimmune diseases such as rheumatoid arthritis are caused by immune system recognition of self-proteins and subsequent production of effector T cells that recognize and attack healthy tissue.
Shalom D. Goldberg, Nathan Felix, Michael McCauley, Ryan Eberwine, Lou Casta, Kathleen Haskell, Tricia Lin, Elizabeth Palovick, Donna Klein, Lori Getts, Robert Getts, Mimi Zhou, Pratima Bansal-Pakala, Vadim Dudkin   +13 more
doaj   +1 more source

Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-Triggered Activation of αβ T Cell Receptors [PDF]

The Journal of Immunology, 2010
Abstract The αβ TCR has recently been suggested to function as an anisotropic mechanosensor during immune surveillance, converting mechanical energy into a biochemical signal upon specific peptide/MHC ligation of the αβ clonotype. The heterodimeric CD3εγ and CD3εδ subunits, each composed of two Ig-like ectodomains, form unique side-to ...
Sun Taek, Kim, Maki, Touma, Koh, Takeuchi, Zhen-Yu J, Sun, Vibhuti P, Dave, Dietmar J, Kappes, Gerhard, Wagner, Ellis L, Reinherz   +7 more
openaire   +2 more sources