T Helper Cells and Cytokine Networks in the Immunopathogenesis of Multiple Sclerosis [PDF]
ImmunoTargets and TherapySimeon Ikechukwu Egba,1,2 Gavin Chibundu Ikechukwu,2 Chinenye Iheanyi Okereke,2 Innocent Ogheneovo Orhonigbe,3 Robert Ikechukwu Uroko,2 Okechukwu Paul Chima Ugwu1 1Department of Biochemistry, Kampala International University, Kampala, Uganda; 2Department
Egba SI +5 more
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A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy. [PDF]
PLoS ONE, 2016 Aurora Kinase A is a cancer-associated protein normally involved in the regulation of mitosis. Being over-expressed in a range of cancers, it is a suitable target for cell-based immunotherapy. Gene transfer of T-cell receptor sequences cognisant of HLA-A*
Nicholas Paul Casey +7 more
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Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.
PLoS Computational Biology, 2021 The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients contain antigen receptors able to specifically identify tumor cells.
Miri Gordin +10 more
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Targeting the melanoma-associated antigen CSPG4 with HLA-C*07:01-restricted T-cell receptors
Frontiers in Immunology, 2023 IntorductionChondroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight-melanoma associated antigen, is expressed in melanoma but also other tumor entities and constitutes an attractive target for immunotherapeutic approaches.
Korbinian N. Kropp +9 more
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Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors [PDF]
Vojnosanitetski Pregled, 2011 Background/Aim. Hemophilia A patients with inhibitors are treated effectively with immune tolerance induction (ITI) therapy. Although anti-idiotypic antibodies may play a certain role in the underlying mechanism, the detailed mechanism by which ITI ...
Sakurai Yoshihiko +5 more
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A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery
Pharmaceutics, 2021 Autoimmune diseases such as rheumatoid arthritis are caused by immune system recognition of self-proteins and subsequent production of effector T cells that recognize and attack healthy tissue.
Shalom D. Goldberg +13 more
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Scientific Reports, 2023 Throughout the COVID-19 pandemic, several variants of concern (VoC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have evolved, affecting the efficacy of the approved COVID-19 vaccines.
Katarzyna Kuczkowska +16 more
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Frontiers in Immunology, 2021 The antigen-independent, strong proliferative responses of naive CD8+ T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors.
Gil-Woo Lee +11 more
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The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production. [PDF]
PLoS ONE, 2012 Paired immunoglobulin-like receptors beta, PILRβ, and alpha, PILRα, are related to the Siglec family of receptors and are expressed primarily on cells of the myeloid lineage.
Cristina M Tato +11 more
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Single Cell T Cell Receptor Sequencing: Techniques and Future Challenges
Frontiers in Immunology, 2018 The peculiarity of T cell is their ability to recognize an infinite range of self and foreign antigens. This ability is achieved during thymic development through a complex molecular mechanism based on somatic recombination that leads to the expression ...
Marco De Simone +3 more
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