Results 21 to 30 of about 16,021,194 (228)

Role of regulatory T cells in immune tolerance [PDF]

, 2009
In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
core   +1 more source

Innate immune activation in experimental autoimmune myocarditis [PDF]

, 2007
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and frequently results from postinfectious autoimmunity. Its pathophysiology is modeled by experimental autoimmune myocarditis (EAM), a CD4+ T-cell mediated murine model of ...
Marty, René Roger
core   +1 more source

Dexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-κB signaling pathways

Scientific Reports, 2017
Treatment of patients with glucocorticoids can result in an increased risk of infection with pathogens such as fungi. Dectin-1 is a member of the C-type lectin receptor superfamily and was shown to be one of the major receptors for fungal beta-glucans ...
Philipp Kotthoff, Annkristin Heine, Stefanie Andrea Erika Held, Peter Brossart   +3 more
doaj   +1 more source

IL-5 and IL-5 receptor in asthma

Memorias do Instituto Oswaldo Cruz, 1997
Eosinophils, along with mast cells are key cells involved in the innate immune response against parasitic infection whereas the adaptive immune response is largely dependent on lymphocytes. In chronic parasitic disease and in chronic allergic disease, IL-
ATC Kotsimbos, Q Hamid
doaj   +3 more sources

Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy

Frontiers in Immunology
γδ T cells, a type of specialized T cell, differ from alpha-beta T cells due to the presence of γ and δ chain surface T cell receptors. These receptors allow them to directly recognize and bind antigenic molecules without the requirement of attachment to
Lu Wang, Jiaqi Li, Yaping Xuan, Jinrui Zhang, Xiao Wang, Wei Hu, Wei Hu, Wei Hu, Lei Xiu   +8 more
doaj   +1 more source

Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor beta-chain [PDF]

, 2010
Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)
Burkhardt, H, Dzhambazov, Balik, Bockermann, Robert, Bettina Sehnert, Batsalova, Tsvetelina, Harald Burkhardt, Burkhardt, Harald, Robert Bockermann, Baecklund, Johan, Batsalova, T, Bockermann, R, Dzhambazov, B, Merky, Patrick, Baecklund, J, Bäcklund, Johan, Sehnert, B, Patrick Merky, Sehnert, Bettina, Balik Dzhambazov, Tsvetelina Batsalova, Lund University., Johan Backlund, Merky, P,, Bockermann, Robert,   +23 more
core   +1 more source

Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific [PDF]

, 1998
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells.
Ogg, GS, Christopher A. O'Callaghan, Philip J.R. Goulder, O'Callaghan, CA, Allen, RL, Anthony Kelleher, Andy K. Sewell, Rowland-Jones, Sarah, Jamie D.K. Wilson, Kelleher, A, Mcmichael, Andrew, Goulder, PJ, Andrew J. McMichael, O'Callaghan, Christopher, Graham S. Ogg, Rachel L. Allen, Rowland-Jones, SL, Callan, MF, Wilson, JD, Sarah L. Rowland-Jones, Margaret F.C. Callan, Sewell, AK, McMichael, AJ   +22 more
core   +1 more source

Clinical applications of gamma delta T cells with multivalent immunity

Frontiers in Immunology, 2014
Gamma delta T cells hold promise for adoptive immunotherapy because of their reactivity to bacteria, viruses, and tumors. However, these cells represent a small fraction (1-5%) of the peripheral T-cell pool and require activation and propagation to ...
Drew C Deniger, Judy S Moyes, Laurence JN Cooper   +2 more
doaj   +1 more source

Bradykinin B2 receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses [PDF]

, 2007
Although the concept that dendritic cells (DCs) recognize pathogens through the engagement of Toll-like receptors is widely accepted, we recently suggested that immature DCs might sense kinin-releasing strains of Trypanosoma cruzi through the triggering ...
Müller-Esterl Werner, Alessandra Granato, Schmitz Verônica, Scharfstein Julio, Tanowitz Herbert B, Scharfstein, Julio, Werner Müller-Esterl, Fnu Nagajyothi, de Arruda Luciana Barros, Nagajyothi, Fnu, Granato Alessandra, Pesquero João B, Müller-Esterl, Werner, Schmitz, Verônica, Luciana Barros de Arruda, Alexandre Morrot, Granato, Alessandra, Barros de Arruda, Luciana, Morrot Alexandre, Monteiro, Ana Carolina, Tanowitz, Herbert B., Julio Scharfstein, Nagajyothi Fnu, Morrot, Alexandre, Verônica Schmitz, João B Pesquero, Pesquero, João B., Monteiro Ana Carolina, Ana Carolina Monteiro, Herbert B Tanowitz   +29 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source