Frontiers in Immunology, 2021 The antigen-independent, strong proliferative responses of naive CD8+ T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors.
Gil-Woo Lee +11 more
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Scientific Reports, 2023 Throughout the COVID-19 pandemic, several variants of concern (VoC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have evolved, affecting the efficacy of the approved COVID-19 vaccines.
Katarzyna Kuczkowska +16 more
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Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation. [PDF]
Proceedings of the National Academy of Sciences, 1988 Alterations in gene expression that orchestrate eukaryotic cellular differentiation often require appropriate interactions between differentiating cells and a specialized microenvironment. During T-lymphocyte differentiation, immature thymocytes undergo a stringent intrathymic selection process that requires intimate contact with thymic stromal ...
E R, Richie +5 more
openaire +2 more sources
The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production. [PDF]
PLoS ONE, 2012 Paired immunoglobulin-like receptors beta, PILRβ, and alpha, PILRα, are related to the Siglec family of receptors and are expressed primarily on cells of the myeloid lineage.
Cristina M Tato +11 more
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Single Cell T Cell Receptor Sequencing: Techniques and Future Challenges
Frontiers in Immunology, 2018 The peculiarity of T cell is their ability to recognize an infinite range of self and foreign antigens. This ability is achieved during thymic development through a complex molecular mechanism based on somatic recombination that leads to the expression ...
Marco De Simone +3 more
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Soluble T-cell receptors produced in human cells for targeted delivery. [PDF]
PLoS ONE, 2015 Recently, technology has become available to generate soluble T-cell receptors (sTCRs) that contain the antigen recognition part. In contrast to antibodies, sTCRs recognize intracellular in addition to extracellular epitopes, potentially increasing the ...
Even Walseng +6 more
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Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. [PDF]
The Journal of experimental medicine, 1996 Thymic selection of natural killer-1+ natural T cells that express alpha beta T cell receptors requires a conserved beta 2-microglobulin-associated molecule, presumably CD1d, displayed by CD4+8+ thymocytes. Here we demonstrate that positive selection of natural T cells occurs independent of transporters associated with antigen presentation-1 (TAP-1 ...
S, Joyce +7 more
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Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
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Review: ‘Gimme five’: future challenges in multiple sclerosis. ECTRIMS Lecture 2009 [PDF]
, 2010 This article is based on the ECTRIMS lecture given at the 25th ECTRIMS meeting which was held in Düsseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the
Bartholomaus I. +44 more
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Can We Improve Vaccine Efficacy by Targeting T and B Cell Repertoire Convergence?
Frontiers in Immunology, 2019 Traditional vaccine development builds on the assumption that healthy individuals have virtually unlimited antigen recognition repertoires of receptors in B cells and T cells [the B cell receptor (BCR) and TCR respectively].
Katja Fink
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