Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development [PDF]
, 2010 PhDThe pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes through the “β-selection ...
Mahtani-Patching, Juliet L
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Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]
, 2012 NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
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Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms [PDF]
, 2005 Integrins are adhesion receptors that are crucial to the functions of multicellular organisms. Integrin-mediated adhesion is a complex process that involves both affinity regulation and cytoskeletal coupling, but the molecular mechanisms behind this ...
Susanna C. Fagerholm +11 more
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Regional and global changes in TCR [alpha][beta] T cell repertoires in the gut are dependent upon the complexity of the enteric microflora [PDF]
, 2010 The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing
Beal, R.K. +28 more
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Soluble T-cell receptors produced in human cells for targeted delivery. [PDF]
PLoS ONE, 2015 Recently, technology has become available to generate soluble T-cell receptors (sTCRs) that contain the antigen recognition part. In contrast to antibodies, sTCRs recognize intracellular in addition to extracellular epitopes, potentially increasing the ...
Even Walseng +6 more
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Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells [PDF]
, 2008 Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery.
Bodnár, Andrea +24 more
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Studies on the affinity control of T cell development [PDF]
, 2004 Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
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Can We Improve Vaccine Efficacy by Targeting T and B Cell Repertoire Convergence?
Frontiers in Immunology, 2019 Traditional vaccine development builds on the assumption that healthy individuals have virtually unlimited antigen recognition repertoires of receptors in B cells and T cells [the B cell receptor (BCR) and TCR respectively].
Katja Fink
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Structural and biophysical insights into the role of CD4 and CD8 in T cell activation
Frontiers in Immunology, 2013 T cell receptors (TCRs) recognize peptides presented by MHC molecules (pMHC) on an antigen-presenting cell (APC) to discriminate foreign from self antigens and initiate adaptive immune responses.
Yili eLi, Roy eMariuzza
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Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]
, 1996 To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E. +2 more
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