Results 31 to 40 of about 132,216 (243)

Antigen Feeding Increases Frequency and Antigen-specific Proliferation Ability of Intraepithelial CD4⁺T Cells in αβ T Cell Receptor Transgenic Mice

Bioscience, Biotechnology, and Biochemistry, 2003
To study how intestinal intraepithelial lymphocytes (IEL) are affected by orally ingested antigen, the phenotypes and responses of the IEL in mice expressing a transgenic T cell receptor alphabeta (TCR alphabeta) specific for ovalbumin (OVA) were analyzed after feeding OVA.
GOTO, Masao, HACHIMURA, Satoshi, AMETANI, Akio, SATO, Takehito, KUMAGAI, Yoshihiro, HABU, Sonoko, TOTSUKA, Mamoru, ISHIKAWA, Hiromichi, KAMINOGAWA, Shuichi   +8 more
openaire   +2 more sources

Profound alteration in an alpha beta T-cell antigen receptor repertoire due to polymorphism in the first complementarity-determining region of the beta chain. [PDF]

Proceedings of the National Academy of Sciences, 1991
Amino acid residues that are critical in maintaining the framework structure of immunoglobulin heavy- and light-chain variable (V) regions are strongly conserved in the V alpha and V beta proteins of the alpha beta T-cell antigen receptor (TCR alpha beta).
S J, Gahm, B J, Fowlkes, S C, Jameson, N R, Gascoigne, M M, Cotterman, O, Kanagawa, R H, Schwartz, L A, Matis   +7 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Generation of NK1.1⁺T cell antigen receptor α/β⁺thymocytes associated with intact thymic structure [PDF]

Proceedings of the National Academy of Sciences, 1997
The development of T cells within the thymus is largely dependent on intact cortical and medullary epithelial cells. However, it has been reported that positive selection of natural killer antigen 1.1+(NK1.1+) T cell antigen receptor (TCR)-α/β+thymocytes recently identified among CD4+8−and CD4−8−subpopulations is attributable to major ...
K, Nakagawa, K, Iwabuchi, K, Ogasawara, M, Ato, M, Kajiwara, H, Nishihori, C, Iwabuchi, H, Ishikura, R A, Good, K, Onoé   +9 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history

Communications Biology
Conventional T cells recognize peptides presented by the human leukocyte antigen (HLA) proteins through their T cell receptors (TCRs). Given that thousands of HLA proteins have been discovered, each presenting thousands of different peptides, decoding ...
Hesham ElAbd, Aya K. H. Mahdy, Eike Matthias Wacker, Maria Gretsova, David Ellinghaus, Astrid Dempfile, Andre Franke   +6 more
doaj   +1 more source

Comparative analysis of CDR3 regions in paired human αβ CD8 T cells

FEBS Open Bio, 2019
The majority of human CD8 cytotoxic T lymphocytes express αβ T‐cell receptors that recognize peptide–MHC class I complexes. Considerable attention has been devoted to TCR β repertoires, but study of TCR α chains has been limited.
Kun Yu, Ji Shi, Dan Lu, Qiong Yang
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source