Results 31 to 40 of about 242,999 (280)

Generation of NK1.1⁺T cell antigen receptor α/β⁺thymocytes associated with intact thymic structure [PDF]

Proceedings of the National Academy of Sciences, 1997
The development of T cells within the thymus is largely dependent on intact cortical and medullary epithelial cells. However, it has been reported that positive selection of natural killer antigen 1.1+(NK1.1+) T cell antigen receptor (TCR)-α/β+thymocytes recently identified among CD4+8−and CD4−8−subpopulations is attributable to major ...
K, Nakagawa, K, Iwabuchi, K, Ogasawara, M, Ato, M, Kajiwara, H, Nishihori, C, Iwabuchi, H, Ishikura, R A, Good, K, Onoé   +9 more
openaire   +2 more sources

Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus. [PDF]

, 2017
Modified measles virus (MV) has effective oncolytic activity preclinically and is currently being investigated in clinical trials for various types of cancer. We investigated the use of cystine knot proteins (CKPs) to direct MV activity.
Lal, Sangeet, Raffel, Corey
core   +2 more sources

Association of FCGR3A and FCGR3B haplotypes with rheumatoid arthritis and primary Sjögren's syndrome [POSTER PRESENTATION] [PDF]

, 2005
Background Rheumatoid arthritis (RA) is an autoimmune disease that is thought to arise from a complex interaction between multiple genetic factors and environmental triggers.
Barrett, J.H., Bowman, S.J., Conaghan, P.G., Cooper, D., Emery, P., Green, M., Haroon-Rashid, L., Isaacs, J.D., Lawson, C.A., Mackie, S., Martin, S., Morgan, A.W., Pease, C.T., Quinn, M., Robinson, J.I.   +14 more
core   +2 more sources

IL-5 and IL-5 receptor in asthma

Memorias do Instituto Oswaldo Cruz, 1997
Eosinophils, along with mast cells are key cells involved in the innate immune response against parasitic infection whereas the adaptive immune response is largely dependent on lymphocytes. In chronic parasitic disease and in chronic allergic disease, IL-
Kotsimbos ATC, Hamid Q
doaj   +3 more sources

Dexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-κB signaling pathways

Scientific Reports, 2017
Treatment of patients with glucocorticoids can result in an increased risk of infection with pathogens such as fungi. Dectin-1 is a member of the C-type lectin receptor superfamily and was shown to be one of the major receptors for fungal beta-glucans ...
Philipp Kotthoff, Annkristin Heine, Stefanie Andrea Erika Held, Peter Brossart   +3 more
doaj   +1 more source

Prospects for γδ T cells and chimeric antigen receptor γδ T cells in cancer immunotherapy

Frontiers in Immunology
γδ T cells, a type of specialized T cell, differ from alpha-beta T cells due to the presence of γ and δ chain surface T cell receptors. These receptors allow them to directly recognize and bind antigenic molecules without the requirement of attachment to
Lu Wang, Jiaqi Li, Yaping Xuan, Jinrui Zhang, Xiao Wang, Wei Hu, Wei Hu, Wei Hu, Lei Xiu   +8 more
doaj   +1 more source

In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset. [PDF]

The Journal of experimental medicine, 1993
We analyzed the T cell receptor (TCR) rearrangements of 100 TCR-alpha/beta CD4-CD8- (double negative [DN]) T cell clones from normal individuals. We found that in four out of six donors this subset contains expanded clones that often account for 0.5% and, in one individual, even 7% of all peripheral blood lymphocytes.
P, Dellabona, G, Casorati, B, Friedli, L, Angman, F, Sallusto, A, Tunnacliffe, E, Roosneek, A, Lanzavecchia   +7 more
openaire   +2 more sources

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. [PDF]

The Journal of experimental medicine, 1995
The dose of foreign antigen can influence whether a cell-mediated or humoral class of immune response is elicited, and this may be largely accounted for by the development of CD4+ T helper cells (Th) producing distinct sets of cytokines. The ability of antigen dose to direct the development of a Th1 or Th2 phenotype from naive CD4+ T cells, however ...
N A, Hosken, K, Shibuya, A W, Heath, K M, Murphy, A, O'Garra   +4 more
openaire   +2 more sources

Clinical applications of gamma delta T cells with multivalent immunity

Frontiers in Immunology, 2014
Gamma delta T cells hold promise for adoptive immunotherapy because of their reactivity to bacteria, viruses, and tumors. However, these cells represent a small fraction (1-5%) of the peripheral T-cell pool and require activation and propagation to ...
Drew C Deniger, Judy S Moyes, Laurence JN Cooper   +2 more
doaj   +1 more source

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]

, 2006
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer, A.A. Dandekar, A.D. Luster, B. Mehrad, B. Parra, B. Parra, B.D. Pearce, B.P. Chen, B.T. Fife, C. Gerard, C. Ramakrishna, C. Ramakrishna, C.A. Biron, C.E. Patterson, C.J. Raport, C.M. Hogaboam, D. Franciotta, D. Galimberti, D. Whiting, D.D. Taub, D.J. Mahad, D.M. Muller, D.N. Cook, D.P. Widney, E. Lazzeri, E.J. McMahon, F.R. Fischer, F.S. Cheever, G. Penna, G. Penna, G.B. Huffnagle, G.C. Hildebrandt, G.F. Wu, H. Bartosik-Psujek, H.G. Fischer, H.G. Fischer, I. Banisor, I. Clark-Lewis, I. Salomon, I. Tsunoda, I.E. Flesch, J. Gosling, J.B. Domachowske, J.C. Houck, J.F. Bazan, J.H. Dufour, J.H. Xie, J.J. Phillips, J.M. Farber, J.S. Haring, J.S. Haring, J.S. Williamson, J.S. Williamson, K. Holmes, K. McIntosh, K.E. Balashov, K.S. Held, K.S. Warmington, K.V. Holmes, L. Boring, L. Boring, L. Cartier, L. Gu, L. Gu, L. Pewe, L. Pewe, M. Baggiolini, M. Greter, M. Matsui, M.A. Olszewski, M.J. Buchmeier, M.J. Trifilo, M.J. Trifilo, M.J. Trifilo, M.M. Lai, M.T. Lin, M.T. Lin, M.T. Liu, M.T. Liu, M.T. Liu, N. Sato, N.J. Megjugorac, N.W. Marten, R. Gade-Andavolu, R. Watanabe, R.F. Castro, R.S. Klein, S. Narumi, S. Qin, S. Xue, S.A. Stohlman, S.A. Stohlman, S.D. Miller, S.M. Stamatovic, S.R. Perlman, T.E. Lane, T.E. Lane, T.E. Lane, T.L. Sorensen, T.L. Sorensen, T.S. Kim, T.S. Kim, W.G. Glass, W.G. Glass, W.G. Glass, W.G. Glass, W.J. Karpus, Y. Zhang, Y. Zhou   +108 more
core   +1 more source